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Antibiotics publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Fungal Metabolites and Synthetic Derivatives as Sources of Antimicrobial Agents: From Discovery to Therapeutic Potential

edited by

João Vicente Braga De Souza

submission deadline 31 Jan 2027 | 2 articles | Viewed by 6139 | Submission Open

Keywords: antimicrobial resistance; fungal metabolites; synthetic derivatives; antifungal agents; bioactive compounds

(This special issue belongs to the Section Fungi and Their Metabolites)

Secondary Metabolites from Natural Sources: Mechanisms of Antimicrobial Action and Therapeutic Potential

edited by

Fatima Cerqueira

and

Maria Pia Ferraz

submission deadline 31 Jan 2027 | 2 articles | Viewed by 5770 | Submission Open

Keywords: secondary metabolites; bioactive compounds

(This special issue belongs to the Section Plant-Derived Antibiotics)

Antimicrobial Resistance in the Wildlife

edited by

Francesca Piras

and Giuliana Siddi

submission deadline 31 Jan 2027 | 4 articles | Viewed by 5357 | Submission Open

Keywords: wildlife; wild animal; antimicrobial resistance; transmission; spread; One Health

Antimicrobial Resistance and Intervention Strategies in Intestinal Pathogens: A One Health Approach

edited by Gaetano Iaquinto

submission deadline 31 Jan 2027 | 1 articles | Viewed by 5179 | Submission Open

Keywords: epidemiology; antimicrobial resistance; multi-drug resistance; immunomodulatory activity; cytokines; gut microbiota; new antibiotics research; new vaccines; faecal microbiota transplantation; infection prevention

Rethinking Mild Infections: The Role of Natural Products in Antimicrobial Stewardship

edited by

Karel Kostev

submission deadline 31 Jan 2027 | 4 articles | Viewed by 4209 | Submission Open

Keywords: natural products; herbal products; phytopharmaceutical; antimicrobial resistance; respiratory tract infections; urinary tract infections

Antimicrobial Activity of Natural Products and Plants Extracts, 2nd Edition

edited by

Mihaela Niculae

and

Daniela Hanganu

submission deadline 31 Jan 2027 | 3 articles | Viewed by 4179 | Submission Open

Keywords: natural products; plant extracts; bioactive compounds; phytoconstituents; antibacterial efficacy; in vitro screening; in vivo evaluation; antibiofilm; anti-quorum

(This special issue belongs to the Section Plant-Derived Antibiotics)

Antimicrobial Peptides (AMPs) Against Human Pathogens

edited by

Pedro Souza

submission deadline 31 Jan 2027 | 3 articles | Viewed by 3332 | Submission Open

Keywords: antimicrobial peptides (AMPs); mechanisms; structure–function relationships; synthetic and bioengineered peptides

(This special issue belongs to the Section Antimicrobial Peptides)

Antibiotic Use and the Emergence of Antibiotic Resistance in Clinical Settings, 2nd Edition

edited by

Aleksandra Barac

submission deadline 31 Jan 2027 | 2 articles | Viewed by 3153 | Submission Open

Keywords: antibiotic use; antibiotic resistance; clinical settings; clinical infections; mechanisms underlying the development of resistance

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

From Epidemiology to Intervention: Addressing the Spread of Multidrug-Resistant Microorganisms

edited by

Silvia Di Lodovico

submission deadline 31 Jan 2027 | 5 articles | Viewed by 2874 | Submission Open

Keywords: multidrug-resistant microorganisms; antimicrobial resistance; epidemiological surveillance; infection prevention and control; antimicrobial stewardship; one health; public health interventions

Antimicrobial Stewardship in Older Adults

edited by Elisa Fabbri

submission deadline 31 Jan 2027 | 2 articles | Viewed by 2772 | Submission Open

Keywords: antimicrobial stewardship; older adults; antimicrobial treatment

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Antimicrobial Resistance in Bacterial Pathogens: Surveillance, Mechanisms, and Diagnostics

edited by Mariela E. Srednik

submission deadline 31 Jan 2027 | 3 articles | Viewed by 2013 | Submission Open

Keywords: antimicrobial resistance; bacterial pathogens; surveillance; diagnostics

Molecular Epidemiology and Antibiotic Resistance in MRSA: Recent Advances in Surveillance and Control

edited by

Jae-Seok Kim

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1995 | Submission Open

Keywords: Staphylococcus aureus; methicillin-resistant S. aureus (MRSA); hospital-associated MRSA (HA-MRSA); antimicrobial resistance; molecular epidemiology; evolution of resistance; surveillance

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Advanced Antimicrobial and Bioactive Coatings for Broad-Spectrum Protection

edited by

José Roberto Souza Almeida Leite

and

Andreanne Gomes Vasconcelos

submission deadline 31 Jan 2027 | 1 articles | Viewed by 1919 | Submission Open

Keywords: antimicrobial coatings; bioactive surfaces; smart coatings for health; broad-spectrum antimicrobial materials; nanotechnology in antimicrobial coatings; disinfectant-compatible coatings; surface functionalization for microbial control; sustainable antimicrobial strategies

(This special issue belongs to the Section Antimicrobial Materials and Surfaces)

Food-Borne Pathogens and Antimicrobial Resistance, 2nd Edition

edited by

Carlos M. Franco

and

Adrian Olariu-Jurca

submission deadline 31 Jan 2027 | Viewed by 904 | Submission Open

Keywords: foodborne pathogens; antibiotic susceptibility; molecular epidemiology investigations; new generation antibiotic agents; horizontal gene transfer; whole genome sequencing

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Antibiotic Resistance in a One Health Context: Bridging Environmental, Agricultural, Nutritional, Veterinary, and Clinical Perspectives, 2nd Edition

edited by

Pedro A. Jiménez Gómez

and

Marina Robas Mora

submission deadline 31 Jan 2027 | 2 articles | Viewed by 807 | Submission Open

Keywords: antibiotic resistance; One Health; environmental microbiology; zoonotic pathogens; antimicrobial stewardship; resistance mechanisms; horizontal gene transfer; integrated surveillance; microbial ecology; public health

(This special issue belongs to the Section Antibiotics in Animal Health)

Feature Reviews in Antibiotics Use and Antimicrobial Stewardship 2026

edited by

Albert Figueras

submission deadline 31 Jan 2027 | Viewed by 615 | Submission Open

Keywords: antibiotic use; antimicrobial stewardship; antimicrobial consumption; interventions; primary care

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Helicobacter pylori Infections: The Detection, Surveillance and Treatment

edited by

Tomica Milosavljević

submission deadline 31 Jan 2027 | 1 articles | Viewed by 591 | Submission Open

Keywords: Helicobacter pylori infection; diagnosis; surveillance; treatment

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Clostridioides difficile Infection: Pathogenesis, Antibiotic Resistance, and Therapeutic Advances

edited by

Yongrong Zhang

submission deadline 31 Jan 2027 | Viewed by 507 | Submission Open

Keywords: Clostridioides difficile; infection; recurrence; antibiotic resistance; therapeutics; pathogenesis

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Antibiotic Therapies for Multidrug-Resistant Infections

edited by

Antonio Riccardo Buonomo

submission deadline 31 Jan 2027 | Viewed by 425 | Submission Open

Keywords: MDR; gram-negative infections; acinteobacter baumannii; stenotrophomonas maltophilia; KPC; MBL

Plant-Derived Nanoantibiotics: Innovations and Applications

edited by

Luciano Paulino Silva

submission deadline 31 Jan 2027 | Viewed by 368 | Submission Open

Keywords: nanotechnology; plant-derived antibiotics; nanoparticles; antimicrobial resistance; green synthesis; drug delivery; nano-formulations; bioactive compounds; nanoantibiotics

Plant Secondary Metabolites Targeting Biofilms and Antibiotic Resistance

edited by

Nilofar Nilofar

submission deadline 31 Jan 2027 | Viewed by 307 | Submission Open

Keywords: plant secondary metabolites; antibacterial; biofilms; antioxidant; antibiotic-resistance; phenolics; flavonoids

(This special issue belongs to the Section Plant-Derived Antibiotics)

Antibiotic Strategy for Ventilator-Associated Respiratory Infections

edited by

Fernando Martínez-Sagasti

submission deadline 31 Jan 2027 | Viewed by 304 | Submission Open

Keywords: ventilator-associated pneumonia; ventilator-associated tracheobronchitis; biomarkers; antimicrobial stewardship; rapid diagnostic tests; multidrug-resistant microorganisms; difficult-to-treat microorganisms; combined antibiotic treatment

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Antibiotic Resistance in Africa: Epidemiology, Genomic Surveillance, and One Health Solutions

edited by

Bassam Elgamoudi

submission deadline 31 Jan 2027 | Viewed by 253 | Submission Open

Keywords: antimicrobial resistance; antibiotic resistance; Africa; genomic surveillance; molecular epidemiology; antimicrobial stewardship; resistant pathogens; infectious diseases; AMR surveillance

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Optimizing Antibiotic Use for Sustainable Healthcare

edited by

Pamela Bailey

and Emily Spivak

submission deadline 31 Jan 2027 | Viewed by 239 | Submission Open

Keywords: antimicrobial stewardship; climate change; antimicrobial resistance; healthcare sustainability; environmental health

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Pharmacokinetic and Dosing Optimization of Antibiotics in Clinical Infections

edited by

Federico Pea

and

Milo Gatti

submission deadline 31 Jan 2027 | 1 articles | Viewed by 102 | Submission Open

Keywords: antibiotic PK/PD optimization; novel beta-lactam/beta-lactamase inhibitors; TDM-guided strategy; population PK model; antimicrobial resistance

(This special issue belongs to the Section Pharmacokinetics and Pharmacodynamics of Drugs)

Molecular Epidemiology of Resistance Genes

edited by

Stefano Stracquadanio

Andrea Marino

and

Maddalena Calvo

submission deadline 14 Feb 2027 | Viewed by 689 | Submission Open

Keywords: antimicrobial resistance (AMR); One Health; resistance genes; epidemiology; surveillance; horizontal gene transfer; environmental microbiology; veterinary medicine; wastewater monitoring

Diagnostics, Antibiotic Usage and Surgery Related Techniques in Prevention and Treatment of Prosthetic Joint and Implant Related Infections

edited by

Bernd Fink

and

Steffen Ruchholtz

submission deadline 28 Feb 2027 | 6 articles | Viewed by 15626 | Submission Open

Keywords: periprosthetic joint infection; implant-related infection; antibiotics; spacer; diagnosis; septic revision arthroplasty; irrigation; debridement

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Pharmacokinetics and Pharmacodynamics of Antibacterial and Antivirulence Drugs, 2nd Edition

edited by

Takahisa Yano

submission deadline 28 Feb 2027 | 4 articles | Viewed by 11450 | Submission Open

Keywords: pharmacokinetics; pharmacodynamics; clinical trials; antimicrobial resistance; antibacterials; antivirulence drugs; pathoblockers; antimicrobial use; drug utilization studies; PK/PD modeling; PBPK-modeling

(This special issue belongs to the Section Pharmacokinetics and Pharmacodynamics of Drugs)

Antibiotics: Utilization, Resistance, and Infection Prevention

edited by

Tafadzwa Dzinamarira

and

Claude Mambo Muvunyi

submission deadline 28 Feb 2027 | 2 articles | Viewed by 8000 | Submission Open

Keywords: antibiotic resistance; antimicrobial stewardship; infection prevention; antibiotic stewardship programs; antimicrobial resistance mechanisms; infection control; rapid diagnostics; public health and AMR; antibiotic alternatives; surveillance systems

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Pharmacist-Led Management of Antimicrobial Treatment

edited by

Doris Rušić

and Lovre Zekan

submission deadline 28 Feb 2027 | 4 articles | Viewed by 5416 | Submission Open

Keywords: antimicrobial stewardship; community pharmacy; antibiotic resistance; antimicrobial use optimisation; pharmacist intervention; antibiotic prescribing; infectious diseases

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Essential Oils as Natural Antimicrobials: Extraction, Characterization, and Synergistic Applications

edited by

Sergio A. Rodríguez

, Axel Hollmann and

Douglas Siqueira de Almeida Chaves

submission deadline 28 Feb 2027 | 3 articles | Viewed by 5004 | Submission Open

Keywords: natural antimicrobials; biofilm eradication; mechanism of action; synergism; antagonism; cytotoxicity; compound isolation; membrane interaction; enzymatic inhibition; DNA interaction; oxidative stress

(This special issue belongs to the Section Plant-Derived Antibiotics)

Mastitis: Causative Agents, Drug Resistance, and Treatment Approaches—2nd Edition

edited by

Amira A. Moawad

Hosny El-Adawy

and Heinrich Neubauer

submission deadline 28 Feb 2027 | 2 articles | Viewed by 2892 | Submission Open

Keywords: mastitis; etiology; multi-drug resistance; alternative bovine mastitis treatment; WGS

(This special issue belongs to the Section Antibiotics in Animal Health)

Epidemiology of and Antibiotic Therapy for Helicobacter pylori Infection

edited by

Peter Birinyi

submission deadline 28 Feb 2027 | 2 articles | Viewed by 2629 | Submission Open

Keywords: Helicobacter pylori infection; bismuth citrate; metronidazole; tetracycline; amoxicillin; clarithromycin; proton pump inhibitor; amoxicillin

Successful Antimicrobial Stewardship Approaches to Address Nosocomial Infections, 2nd Edition

edited by

Eduardo Rodríguez-Noriega

submission deadline 28 Feb 2027 | 1 articles | Viewed by 2028 | Submission Open

Keywords: bacterial; resistance; antimicrobial; stewardship

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Marine-Derived Antibiotics

edited by

Ines Mancini

and

Andrea Defant

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1416 | Submission Open

Keywords: marine natural products; structural characterization; improved production of bioactive secondary metabolites; organic synthesis; structure–activity relationship (SAR); pathogen bacteria inhibition; antibiofilm activity; computational analysis; drug discovery; drug delivery systems

(This special issue belongs to the Section Novel Antimicrobial Agents)

Antimicrobial Agents Targeting Biofilms

edited by

Domenico Schillaci

submission deadline 28 Feb 2027 | 2 articles | Viewed by 1413 | Submission Open

Keywords: biofim associated infections; virulence factors; antibiofilm agents

Strategies for Combatting Multidrug-Resistant and Extensively Drug-Resistant Bacteria, 3rd Edition

edited by

Bożena Futoma-Kołoch

and Anna Kędziora

submission deadline 28 Feb 2027 | 2 articles | Viewed by 1280 | Submission Open

Keywords: MDR bacteria; EDR bacteria; novel antimicrobial drugs; novel therapeutical approaches against MDR; novel therapeutical approaches against EDR; guidelines; personalized microbiota; bacteriophages; autovaccine therapy; antimicrobial stewardship

(This special issue belongs to the Section The Global Need for Effective Antibiotics)

Antimicrobial Resistance in Animals and Animal Products and Its Environmental Transmission Aspects, Second Edition

edited by

Nikolaos Solomakos

Thomai Lazou

and

Andreana Pexara

submission deadline 28 Feb 2027 | Viewed by 394 | Submission Open

Keywords: antimicrobial resistance; One Health; AMR dissemination in the environment; antibiotics in animals; foodborne pathogens; animal products

(This special issue belongs to the Section Antibiotics in Animal Health)

Translational Animal Models for Unraveling the Mechanisms of Action of Antimicrobial Peptides and Novel Antibiotics

edited by

Octávio L. Franco

and

Danieli Fernanda Buccini

submission deadline 28 Feb 2027 | Viewed by 383 | Submission Open

Keywords: antimicrobial resistance (AMR); translational research; animal models; preclinical studies; antimicrobial peptides (AMPs); novel antibiotics; pharmacokinetics/pharmacodynamics (PK/PD); in vivo efficacy; infection models; biofilm

(This special issue belongs to the Section Antimicrobial Peptides)

Cystic Fibrosis: Diagnosis and Antimicrobial Therapy in the CFTR Modulator Era

edited by Guergana Petrova

submission deadline 28 Feb 2027 | Viewed by 284 | Submission Open

Keywords: cystic fibrosis; bronchiectasis; advanced lung disease; Pseudomonas aeruginosa; glucose non-fermenting Gram negative bacteria; inhaled antibiotics; mchronic infection; biofilm; sweat test; CFTR-functional testing; genetics for cystic fibrosis

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Emerging Antimicrobial-Resistant Pathogens in the One Health Context: From Reservoirs to Human Infection

edited by

Janira Prichula

and Cezar Riche

submission deadline 28 Feb 2027 | Viewed by 256 | Submission Open

Keywords: One Health; antimicrobial resistance; multidrug-resistant pathogens; genomic epidemiology; transmission dynamics; zoonotic pathogens; environmental reservoirs; resistome; mobile genetic elements; pathogenicity islands

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Antimicrobial Resistance and Prevalence of Pathogens in Tropical and Endemic Regions: Surveillance, Diagnostics, and Therapeutic Strategies

edited by

Ramón Pérez-Tanoira

submission deadline 28 Feb 2027 | Viewed by 250 | Submission Open

Keywords: antimicrobial resistance; tropical regions; pathogen prevalence; epidemiological surveillance; One Health; biofilms; carbapenemase-producing Enterobacteriaceae; multidrug-resistant Pseudomonas aeruginosa; gastrointestinal infections; neglected tropical diseases

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Phages vs. Antibiotics in the Age of Resistance

edited by

Jean Pierre González-Gómez

submission deadline 28 Feb 2027 | Viewed by 210 | Submission Open

Keywords: bacteriophages; antimicrobial resistance; phage therapy; multidrug-resistant bacteria; One Health; alternative antimicrobials

(This special issue belongs to the Section Bacteriophages)

Antimicrobial Stewardship and Infection Prevention in Intensive Care Units—2nd Edition

edited by

Mihai Sava

submission deadline 28 Feb 2027 | Viewed by 183 | Submission Open

Keywords: antimicrobial stewardship; infection prevention; intensive care unit (ICU); antimicrobial resistance; healthcare-associated infections; patient safety

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Discovery and Design of New Antimicrobial Agents, 2nd Edition

edited by

Jean Michel Brunel

submission deadline 10 Mar 2027 | 1 articles | Viewed by 976 | Submission Open

Keywords: antimicrobial agents; fight resistance; new design; structure–activity relationships (SARs)

(This special issue belongs to the Section Novel Antimicrobial Agents)

Antimicrobial Biomaterials for Dentistry

edited by

Edith Lara-Carrillo

submission deadline 15 Mar 2027 | 2 articles | Viewed by 2989 | Submission Open

Keywords: antimicrobials; dentistry; microorganisms; biomaterials; caries risk; oral environment; epidemiology

Long-Acting Antibiotics and Their Use in Clinical Practice

edited by Beatrice Barda

submission deadline 15 Mar 2027 | Viewed by 41 | Submission Open

Keywords: long-acting antibiotics; soft tissue infection; endocarditis; antimicrobial stewardship

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Prophages and Their Derivatives: Emerging Tools for Microbial Biofilm Control

edited by

Fazlurrahman Khan

Nazia Tabassum

and

Young-Mog Kim

submission deadline 20 Mar 2027 | 1 articles | Viewed by 377 | Submission Open

Keywords: prophage; biofilm; endolysin; phage depolymerase; bacteriophage; lysogeny; antimicrobial resistance; extracellular polymeric substances; quorum sensing; ESKAPE pathogens; phage engineering; antibiofilm; lytic enzymes; phage-derived proteins; synthetic biology; MDR pathogens; food safety; chronic infection; CRISPR; metagenomics

(This special issue belongs to the Section Bacteriophages)

Antibiotics in the Environment: Sources, Fate, and Mitigation Strategies, 2nd Edition

edited by Khaled Benis

submission deadline 25 Mar 2027 | Viewed by 221 | Submission Open

Keywords: antibiotic contamination; environmental fate; antibiotic resistance; mitigation strategies; pollution management

Phage Therapy and Antimicrobial Innovation

edited by Ronen Hazan,

Lilach Gavish

and Amit Rimon

submission deadline 31 Mar 2027 | 5 articles | Viewed by 6086 | Submission Open

Keywords: antimicrobial resistance (AMR); antimicrobial innovation; phage therapy; phage engineering; synergistic strategies; chronic infections; biofilm; clinical phage microbiology; personalized medicine

(This special issue belongs to the Section Bacteriophages)

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