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Antibiotics
Special Issues
From Epidemiology to Intervention: Addressing the Spread of Multidrug-Resistant Microorganisms
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From Epidemiology to Intervention: Addressing the Spread of Multidrug-Resistant Microorganisms

A special issue of Antibiotics (ISSN 2079-6382).

Deadline for manuscript submissions: 30 July 2026 | Viewed by 452

Special Issue Editor

Dr. Silvia Di Lodovico

E-Mail Website
Guest Editor
Department of Pharmacy, “G. d’Annunzio” University, 66100 Chieti, Italy
Interests: antimicrobial resistance; anti-biofilm and anti-virulence activities of natural compounds alone and combined with antibiotics against multi drug-resistant strains (Helicobacter pylori, Staphylococcus spp., Pseudomonas aeruginosa, Candida albicans, Mycobacterium abscessus and other fast-growing mycobacteria)
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The global rise of multidrug‑resistant (MDR) microorganisms represents one of the most important challenges regarding public health. Understanding their epidemiology is essential for finding effective ways to counteract infection associated with MDR strains. MDR pathogens spread through complex networks involving hospitals, communities, animals, and the environment, driven by factors such as inappropriate antibiotic use, inadequate infection control practices, and global mobility. Epidemiological surveillance—combining molecular typing, real‑time data analysis, and risk factor assessment—enables researchers to track transmission routes and identify emerging hotspots. A new multifaceted approach from a One Health perspective is therefore necessary. Key strategies include strengthening antimicrobial stewardship programs, improving hygiene and sanitation, implementing rapid diagnostic tools, and promoting evidence‑based infection prevention measures. Bridging epidemiology and new therapeutical solutions could reduce the spread of MDR microorganisms and help to safeguard global health.

Dr. Silvia Di Lodovico
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • multidrug-resistant microorganisms
  • antimicrobial resistance
  • epidemiological surveillance
  • infection prevention and control
  • antimicrobial stewardship
  • one health
  • public health interventions

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Published Papers (1 paper)

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Research

12 pages, 249 KB  
Article
Evaluating the Impact of Filmarray Pneumonia Plus Panel in Therapeutic Decision-Making in Critical Patients with Suspected Respiratory Infection
by Rosa Latorre Ibars, Sulamita Carvalho-Brugger, Paula Rodríguez Ibáñez, Montserrat Vallverdú Vidal, Silvia Iglesias Moles, Mar Miralbés Torner, Alba Bellés Bellés, Andrea Castellano, David Campi, Jesús Caballero and José Javier Trujillano Cabello
Antibiotics 2026, 15(5), 521; https://doi.org/10.3390/antibiotics15050521 - 21 May 2026
Viewed by 160
Abstract
Background: Respiratory infections in critically ill patients remain a major challenge in intensive care units (ICUs), with high morbidity and mortality. Conventional microbiological methods often fail to identify the causative pathogen promptly, particularly in patients previously exposed to antibiotics. Multiplex molecular platforms, such [...] Read more.
Background: Respiratory infections in critically ill patients remain a major challenge in intensive care units (ICUs), with high morbidity and mortality. Conventional microbiological methods often fail to identify the causative pathogen promptly, particularly in patients previously exposed to antibiotics. Multiplex molecular platforms, such as the BioFire FilmArray® Pneumonia Panel Plus (FAPP), allow rapid detection of multiple respiratory pathogens and resistance markers, potentially improving early therapeutic decision-making. The objective of this work is to evaluate the impact of implementing FAPP on antimicrobial therapeutic decisions in critically ill patients with suspected respiratory infection. Methods: We conducted a retrospective cohort study in two mixed ICUs between 2023 and 2024. All respiratory samples in which FAPP was requested were analyzed. The results were compared with conventional cultures, and changes in antimicrobial therapy following the FAPP results were assessed, classified as escalation/initiation or de-escalation/discontinuation. Concordance between FAPP and culture was evaluated, and clinical and demographic variables were analyzed. Differences between groups were assessed using p-values obtained from the chi-square test or the Mann–Whitney test. Results: A total of 363 respiratory samples were included, 88.4% from mechanically ventilated patients. FAPP was positive in 65.3% of samples, whereas cultures were positive in 23.1%. Overall concordance between FAPP and culture was 57.3%. In 42.4% of cases, pathogens were detected exclusively by FAPP. Antimicrobial therapy was modified in 29.8% of patients, predominantly through de-escalation or discontinuation (69.4% of changes). Therapeutic modifications were more frequent in nosocomial infections and in patients with a positive FAPP result. Conclusions: The use of FAPP in critically ill patients with suspected respiratory infection provides rapid microbiological information that significantly influences antimicrobial decision-making, particularly by facilitating antibiotic de-escalation. Although discrepancies with conventional cultures remain and require careful clinical interpretation, FAPP represents a valuable tool for antimicrobial stewardship in the ICU setting. Full article
(This article belongs to the Special Issue From Epidemiology to Intervention: Addressing the Spread of Multidrug-Resistant Microorganisms)
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