Antimicrobial Agents Targeting Biofilms

Dear Colleagues,

Numerous infections are associated with the growth of pathogens in the form of multilayered, sessile microbial communities known as biofilms. Biofilms are characterized by multifactorial antibiotic resistance, whose mechanisms are a combination of adaptive and natural or intrinsic resistance. In addition, the biofilm represents an ideal ecological niche for the horizontal transfer of antibiotic resistance genes among microbes. Due to their resistance and involvement in infectious diseases, biofilms deserve targeted antimicrobials for their treatment. The control of infectious diseases associated with the formation of biofilms remains a challenge that must be addressed effectively and urgently.

In this Special Issue, we will focus on approaches to combat microbial biofilms, preventing their formation or eradicating them, by using in vitro or in vivo models, and we will also focus on the development of potential new therapies. Contributions on the use of bacteriophages, antimicrobial peptides, small synthetic organic molecules, and the reuse of old molecules and conventional antibiotics through new formulations and delivery methods are welcome.

Prof. Dr. Domenico Schillaci
Guest Editor

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