Successful Antimicrobial Stewardship Approaches to Address Nosocomial Infections, 2nd Edition

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotics Use and Antimicrobial Stewardship".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 1038

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Guest Editor
Centro Universitario Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico
Interests: antibiotic resistance; microbiology; antibiotics; bacterial antibiotic resistance; bacteriology; antimicrobial resistance; antibacterial activity; general microbiology; microbial isolation; environmental microbiology
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Special Issue Information

Dear Colleagues,

Successful antimicrobial stewardship approaches are used to address nosocomial infections such as hospital-acquired infections (HAIs), which can occur in outpatient settings, although most occur while the patient is hospitalized.

Patients hospitalized in certain wards, i.e., intensive care units (ICU), have increased risk of acquiring an infection that can be caused by resistant bacteria, requiring the use of reserve antibiotics. The difficulty involved in managing this requires serious consideration of the most appropriate therapy.

Antimicrobial stewardship (AST) is a strategy designed to improve the use of antimicrobials in different settings, including hospitals. However, modifying prescription habits, increasing adherence to therapeutic guidelines, and improving the empirical use of antibiotics can be challenging, especially if microbiological testing is difficult or there are shortages of certain antibiotics.

The pandemic caused by SARS-CoV-2 overshadowed the antimicrobial resistance (AMR) pandemic. At first, antibiotics were increasingly used to treat this viral infection, which helped to increase the AMR phenomenon.

AST should be a clear habit in the minds of all healthcare professionals. Notwithstanding this fact, in real life, implementing AST faces several challenges, including a need for more awareness and education. Furthermore, limited resources allocated for these activities limit the implementation of AST, which should be a continuous task.

This Special Issue seeks studies of successful hospital AST experiences, including innovative and engaging approaches that are useful for the management of antimicrobial resistance.

Dr. Eduardo Rodríguez-Noriega
Guest Editor

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Keywords

  • bacterial
  • resistance
  • antimicrobial
  • stewardship

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Published Papers (1 paper)

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Review

14 pages, 841 KB  
Review
From Gut Commensal to Opportunistic Pathogen: A Narrative Review of Butyricimonas Infections in Humans
by Afroditi Ziogou, Alexios Giannakodimos, Ilias Giannakodimos, Andreas G. Tsantes, Stella Baliou, Dimitrios Rigopoulos and Petros Ioannou
Antibiotics 2026, 15(3), 297; https://doi.org/10.3390/antibiotics15030297 - 14 Mar 2026
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Abstract
Background/Objectives: Butyricimonas species constitute a genus of Gram-negative, anaerobic bacteria that are part of the human gut microbiota. Infections caused by these organisms are extremely rare in clinical practice. While uncommon in the general population, their occurrence is higher among immunocompromised individuals or [...] Read more.
Background/Objectives: Butyricimonas species constitute a genus of Gram-negative, anaerobic bacteria that are part of the human gut microbiota. Infections caused by these organisms are extremely rare in clinical practice. While uncommon in the general population, their occurrence is higher among immunocompromised individuals or patients with significant underlying health conditions. This review aims to compile and analyze all reported cases of human Butyricimonas infections, focusing on epidemiology, microbiological characteristics, antimicrobial resistance patterns, treatment strategies, and associated mortality. Methods: This review was conducted using data retrieved from the PubMed/MEDLINE and Scopus databases. Results: A total of 14 publications described Butyricimonas infections affecting 14 patients. The mean age of those affected was 66.46 years, and 10 (71.4%) were male. The most frequently reported predisposing factor was a history of malignancy, observed in almost one-third of cases (30.8%). Clinically, fever, organ dysfunction, and shock were the most common presentations (fivecases), followed by sepsis and the need for ICU in fourpatients. In vitro studies indicated that the isolates were generally susceptible to carbapenems and metronidazole, with only high resistance levels observed to penicillin. Among the antimicrobial therapies used, carbapenems were the most commonly administered (50%), followed by piperacillin/tazobactam (41.7%) and metronidazole (33.3%). The overall mortality rate across the cohort was 16.7%, with infection-attributable deaths representing 8.3% of cases. Conclusions: Given the potential of Butyricimonas species to cause severe infections, clinicians should consider this organism in patients presenting with unexplained bacteremia or intra-abdominal infections, particularly in the setting of mucosal disruption or immune dysfunction. Full article
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