Antimicrobial Resistance in the Wildlife

A special issue of Antibiotics (ISSN 2079-6382).

Deadline for manuscript submissions: 31 December 2025 | Viewed by 332

Special Issue Editors


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Guest Editor
Department of Veterinary Medicine, Sector of Inspection of Food of Animal Origin, University of Sassari, Via Vienna 2, 07100 Sassari, Italy
Interests: salmonella enterica; yersinia enterocolitica; food safety; antimicrobial resistance; sequencing

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Guest Editor
Department of Veterinary Medicine, University of Sassari, Via Vienna 2, 07100 Sassari, Italy
Interests: food safety; antimicrobial resistance; microbiology

Special Issue Information

Dear Colleagues,

Antimicrobial resistance (AMR) is one of the major challenges of the 21st century that threatens human, animal, and environmental health at a global level, thus requiring a One Health system-thinking approach to counteract it. Although antibiotics misuse and overuse in human and animal healthcare have been considered the main cause of AMR emergence for a long time, nowadays it is ascertained that also anthropogenic activities play a crucial role in the dissemination of antibiotics and antimicrobial resistance genes in the environment, including populated areas but also pristine, natural scenarios and the wildlife.

Wildlife is often referred to as reservoirs, vectors, sentinels, and bioindicators of resistant pathogens and genetic determinants of AMR in the environment; nevertheless, the knowledge regarding the implications of these terms for public health remains unclear, as well as the complex transmission dynamics of AMR at the One Health interface. Moreover, some wild species, especially wild ungulates and wild boars, are now considered sources of human foodborne pathogens due to the manipulation and consumption of game meat.

In this frame, this Special Issue welcomes article submissions that focus on the acquisition of mechanisms of antimicrobial resistance in wildlife, the transmission of antimicrobial resistance between domestic and wild species, environmental sources of antimicrobial resistance in wild species, the role of natural habitats in antimicrobial resistance spreading, public health implications of antimicrobial resistance in wild animals, and surveillance and monitoring of antimicrobial resistance in wildlife.

Acknowledgment: Giuliana Siddi will be participating in this Special Issue as a "special collaborator"; special thanks for her contributions to the Special Issue.

Dr. Francesca Piras
Dr. Giuliana Siddi
Guest Editors

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Keywords

  • wildlife
  • wild animal
  • antimicrobial resistance
  • transmission
  • spread
  • One Health

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Published Papers (1 paper)

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Review

27 pages, 984 KB  
Review
Enteric Pathogens in Wild Boars Across the European Union: Prevalence and Antimicrobial Resistance Within a One Health Framework
by Francesca Piras, Giuliana Siddi, Enrico Pietro Luigi De Santis and Christian Scarano
Antibiotics 2025, 14(12), 1246; https://doi.org/10.3390/antibiotics14121246 - 10 Dec 2025
Abstract
Wild boars, widely distributed across natural, agricultural, and urban landscapes, represent an ideal sentinel species for monitoring the emergence and spread of antimicrobial resistance (AMR) at the human–wildlife–livestock interface within the One Health framework. This review summarizes current knowledge on the prevalence, diversity, [...] Read more.
Wild boars, widely distributed across natural, agricultural, and urban landscapes, represent an ideal sentinel species for monitoring the emergence and spread of antimicrobial resistance (AMR) at the human–wildlife–livestock interface within the One Health framework. This review summarizes current knowledge on the prevalence, diversity, AMR, and epidemiological significance of major enteric pathogens isolated from wild boars in the European Union, with particular attention to their potential role in AMR dissemination. Numerous studies have reported variable prevalence rates for Salmonella spp., Yersinia enterocolitica, Shiga toxin-producing Escherichia coli (STEC), and Campylobacter spp. High prevalence rates has been observed in fecal samples—35% for Salmonella, 27% for Y. enterocolitica and STEC, and 66% for Campylobacter—highlighting the role of wild boars as carriers and the associated risk of carcass contamination during slaughter. Tonsils represent a key niche for Y. enterocolitica, with prevalence reaching 35%. Several studies have identified resistance to antimicrobials classified by the World Health Organization as critically important or high priority for human medicine, including fluoroquinolone-resistant non-typhoidal Salmonella spp. and third-generation cephalosporin-resistant Y. enterocolitica, raising notable public health concerns. Despite increasing interest, most available studies remain descriptive and geographically limited, providing limited insight into AMR acquisition and transmission pathways in wild boars. New approaches—such as resistome analyses and epidemiological cut-off values—offer added value to distinguish wild-type from acquired-resistant strains and to better understand AMR dissemination dynamics. Integrating wildlife into One Health surveillance systems is essential to capture the full complexity of AMR spread. Full article
(This article belongs to the Special Issue Antimicrobial Resistance in the Wildlife)
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