Antibiotics: Utilization, Resistance, and Infection Prevention

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotics Use and Antimicrobial Stewardship".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 2145

Special Issue Editors


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Guest Editor
1. ICAP, Columbia University, New York, NY, USA
2. School of Health Systems and Public Health, University of Pretoria, Pretoria, South Africa
Interests: infectious diseases; epidemiology; health systems; health policy; limited-resource settings
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Guest Editor
1. College of Medicine and Health Sciences, University of Rwanda, Kigali, Rwanda
2. Rwanda Biomedical Centre, Kigali, Rwanda
Interests: infectious diseases; clinical microbiology; tuberculosis; hepatitis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The use of, and resistance to, antibiotics are two of the most pressing challenges in modern medicine, posing a significant threat to public health worldwide. While antibiotics have revolutionized the treatment of infectious diseases, the overuse and misuse of these drugs have led to the rise of antimicrobial resistance (AMR), making previously treatable infections increasingly difficult to manage. This has led to a critical need for innovative strategies in infection prevention, as well as novel approaches to optimizing antibiotic use and curbing the spread of resistance.

In this Special Issue, we will explore the multifaceted relationships among antibiotic use, resistance development, and infection prevention strategies. We invite submissions that address various aspects of AMR, including its mechanisms, transmission dynamics, and global impact. Topics of interest include, but are not limited to, the role of antibiotic stewardship programs, the development and implementation of infection prevention protocols in healthcare settings, and the evaluation of novel antibiotics or alternative treatments. Additionally, we invite the submission of research exploring the impact of antibiotic use in agriculture, veterinary medicine, and the environment on resistance patterns. Furthermore, we welcome studies focusing on the molecular mechanisms of resistance, the role of diagnostic tools in guiding antibiotic therapies, and strategies for improving public awareness and education on antibiotic use. We are also interested in the integration of innovative technologies, such as rapid diagnostics and surveillance systems, to help optimize treatment regimens and reduce unnecessary antibiotic consumption. Our goal for this Special Issue is to provide a comprehensive overview of current research and best practices, facilitating a deeper understanding of how to balance the need for effective antibiotics with the need to preserve their efficacy for future generations. We hope to inspire further investigation and the development of novel strategies to combat antibiotic resistance and improve infection prevention globally. We look forward to receiving your contributions to this important field of study.

Dr. Tapfumanei Mashe from the World Health Organization (Zimbabwe) will collaborate in supporting this Special Issue.

Dr. Tafadzwa Dzinamarira
Prof. Dr. Claude Mambo Muvunyi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antibiotic resistance
  • antimicrobial stewardship
  • infection prevention
  • antibiotic stewardship programs
  • antimicrobial resistance mechanisms
  • infection control
  • rapid diagnostics
  • public health and AMR
  • antibiotic alternatives
  • surveillance systems

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Published Papers (1 paper)

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Research

23 pages, 1172 KiB  
Article
Antimicrobial Stewardship Impact on Antibiotic Use in Three Tertiary Hospitals in Zambia: A Comparative Point Prevalence Survey
by Steward Mudenda, Kenneth Kapolowe, Uchizi Chirwa, Melvin Chanda, Raphael Chanda, Rodney Kalaba, Sombo Fwoloshi, Christabel Phiri, Mukuka Mwamba, Robert Kajaba Chirwa, Kotey Nikoi, Linda Musonda, Kaunda Yamba, Josepsh Yamweka Chizimu, Chitalu Chanda, Tamica Mubanga, Chisha Simutowe, John Kasanga, Mulope Mukanwa, Katongo Hope Mutengo, Philip Matthew, Fabian Maza Arnedo, Jyoti Joshi, Jonathan Mayito, Ruth Nakazwe, Maisa Kasanga and Duncan Chandaadd Show full author list remove Hide full author list
Antibiotics 2025, 14(3), 284; https://doi.org/10.3390/antibiotics14030284 - 10 Mar 2025
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Abstract
Introduction: Antimicrobial stewardship (AMS) can improve the rational use of antibiotics in hospitals. This study assessed the impact of a multifaceted AMS intervention on antibiotic use and prescribing patterns at three tertiary hospitals in Zambia. Methods: Point Prevalence Surveys (PPS) were conducted in [...] Read more.
Introduction: Antimicrobial stewardship (AMS) can improve the rational use of antibiotics in hospitals. This study assessed the impact of a multifaceted AMS intervention on antibiotic use and prescribing patterns at three tertiary hospitals in Zambia. Methods: Point Prevalence Surveys (PPS) were conducted in three tertiary hospitals in August 2022 and in October 2023. It was part of a 3-year AMS demonstration project that aimed to optimize the use of antibiotics in treating urinary tract infections (UTIs) and bloodstream infections (BSIs) in various health sector settings in Zambia. Up to 170 medical records in 2022 and 265 in 2023 were included in the assessment. Results: Overall, the prevalence of antibiotic use in this PPS was 75%. Eighty-one percent (81%) and 71% of patients assessed were on at least one antibiotic in 2022 and 2023, respectively, indicating a decrease of 10%. Similarly, prescribing ceftriaxone, the most prescribed antibiotic, declined from an average of 48% in 2022 to 38% in 2023. Adherence to Standard Treatment Guidelines (STGs) slightly increased from 42% in 2022 to 45% in 2023. Additionally, antibiotic prescribing was reduced from 1.38 to 1.21. Conclusions: Antimicrobial stewardship had an early positive impact on antibiotic use and adherence to Standard Treatment Guidelines. Full article
(This article belongs to the Special Issue Antibiotics: Utilization, Resistance, and Infection Prevention)
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