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  • Article
  • Open Access

Knowledge Deficits Among Community Pharmacists May Drive Antibiotic Resistance in Rural Areas: Evidence from Southern Jordan

  • Anas Khaleel,
  • Anwar Ali Al-Shamaileh,
  • Mohammad Ameen Al-Aghbar,
  • Wael Abu Dayyih,
  • Suhaib Muflih,
  • Haneen Aljamal,
  • Ahmed S. A. Ali Agha,
  • Mohammad Hailat and
  • Ahmad Al Athamneh
Antibiotics2026, 15(1), 4;https://doi.org/10.3390/antibiotics15010004 
(registering DOI)

19 December 2025

Background/Objectives: Antimicrobial resistance (AMR) is a major global health issue. Since community pharmacists are frontline health officials regarding the provision and management of antibiotics, it is of great importance to study the knowledge,...

  • Article
  • Open Access

β,β-Dimethylacrylalkannin Restores Colistin Efficacy Against mcr- and TCS-Mediated Resistant Gram-Negative Bacteria via Membrane Disturbance

  • Yongqing Liu,
  • Huangwei Song,
  • Muchen Zhang,
  • Junyao Jiang,
  • Yan Zhang,
  • Jian Xu,
  • Xi Xia,
  • Shangshang Qin,
  • Jianzhong Shen and
  • Yang Wang
  • + 1 author
Antibiotics2026, 15(1), 3;https://doi.org/10.3390/antibiotics15010003 
(registering DOI)

19 December 2025

Background: The reintroduction of colistin has led to the rapid emergence of colistin-resistant strains, significantly diminishing its therapeutic efficacy. This presents a need for effective adjuvants to restore colistin efficacy. Approach: We scree...

  • Review
  • Open Access

Multidrug-Resistant Acinetobacter baumannii: Resistance Mechanisms, Emerging Therapies, and Prevention—A Narrative Review

  • Ioana Adelina Stoian,
  • Bianca Balas Maftei,
  • Carmen-Elena Florea,
  • Alexandra Rotaru,
  • Constantin Aleodor Costin,
  • Maria Antoanela Pasare,
  • Radu Crisan Dabija and
  • Carmen Manciuc
Antibiotics2026, 15(1), 2;https://doi.org/10.3390/antibiotics15010002 
(registering DOI)

19 December 2025

Acinetobacter baumannii is a leading intensive care unit (ICU) pathogen associated with high rates of carbapenem resistance and poor clinical outcomes. This narrative review synthesizes recent clinical, microbiological, and pharmacokinetic/pharmacody...

  • Article
  • Open Access

An Algorithm for Rapid and Low-Cost Detection of Carbapenemases Directly from Positive Blood Cultures Using an Immunochromatographic Test

  • Patricia del Carmen García,
  • Pamela Rojas,
  • Ana María Guzmán,
  • Sofía Paz Torres and
  • Aniela Wozniak

Background/Objectives: Detection of carbapenemases (KPC, OXA-48, VIM, IMP, NDM) from blood cultures (BCs) by standard methods takes 48–72 h and includes BC seeding, susceptibility testing and carbapenemase detection. Automated qPCR panels provi...

  • Review
  • Open Access

18 December 2025

Background: Antimicrobial resistance (AMR) is accelerating globally, driven by widespread inappropriate antibiotic use and diagnostic uncertainty in primary care. Pharmcist-led point-of-care testing (POCTs) has emerged as a promising model to optimiz...

  • Systematic Review
  • Open Access

Surveillance of Healthcare-Associated Infections in the WHO African Region: Systematic Review of Literature from 2011 to 2024

  • Laetitia Gahimbare,
  • Nathalie K. Guessennd,
  • Claude Mambo Muvunyi,
  • Walter Fuller,
  • Sheick Oumar Coulibaly,
  • Landry Cihambanya,
  • Pierre Claver Kariyo,
  • Olga Perovic,
  • Ambele Judith Mwamelo and
  • Diané Kouao Maxime
  • + 4 authors

18 December 2025

Background: Evidence on HAIs in Africa is fairly common. Objectives: The main objective was to identify the surveillance tools used for healthcare–associated infections (HAIs) in countries in the WHO African Region. Secondary objectives focused...

  • Review
  • Open Access

Extended-Spectrum β-Lactamase-Producing Escherichia coli and Pediatric UTIs: A Review of the Literature and Selected Experimental Observations

  • Vanessa Tamas,
  • Erlinda R. Ulloa,
  • Monika Kumaraswamy,
  • Samira Dahesh,
  • Raymond Zurich,
  • Victor Nizet and
  • Alison Coady

18 December 2025

Urinary tract infections (UTIs) are common in children and are predominantly caused by uropathogenic Escherichia coli (UPEC). An increasing proportion of these strains produce extended-spectrum β-lactamases (ESBLs), which render β-lactam an...

  • Review
  • Open Access

Recent Advances in Endolysin Engineering

  • Mackenzie Aitken,
  • Gayan Abeysekera,
  • Craig Billington and
  • Renwick C. J. Dobson

18 December 2025

Antimicrobial resistance threatens a new “dark age” in medical practice. Chronic antibiotic overuse has driven the rise in antimicrobial resistance and promoted the emergence of multidrug-resistant organisms. To address this problem, rese...

  • Article
  • Open Access

Pathogen-Specific Actinium-225 and Lutetium-177 Labeled Antibodies for Treatment of Biofilm-Associated Implant Infections: Initial In Vivo Proof-of-Concept

  • F. Ruben H. A. Nurmohamed,
  • Kevin J. H. Allen,
  • Mackenzie E. Malo,
  • Connor Frank,
  • J. Fred F. Hooning van Duvenbode,
  • Berend van der Wildt,
  • Alex J. Poot,
  • Marnix G. E. H. Lam,
  • Jos A. G. van Strijp and
  • Peter G. J. Nikkels
  • + 4 authors

18 December 2025

Background: the primary challenge with implant infections is the formation of biofilm, which harbors dormant bacteria that reduce the effectiveness of antibiotics and amplify antibiotic resistance, exacerbating the global antimicrobial resistance cri...

  • Article
  • Open Access

Navigating Antimicrobial Resistance Insights: An In-Depth Analysis of Healthcare Providers’ Knowledge, Attitudes, and Practices, with an Emphasis on Precision Medicine in Pakistan

  • Sidra Shahid,
  • Aiman Athar,
  • Shahzeen Farooq,
  • Madena Yahya,
  • Muhammad Saad Ashraf,
  • Shafaq Mahmood and
  • Abdul Momin Rizwan Ahmad

18 December 2025

Antibiotics play a crucial role in the treatment of many complicated problems in clinical medicine, but antimicrobial resistance (AMR) has emerged as a serious concern threatening to undermine its effectiveness. Precision medicine (PM) which tailors...

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Antibiotics - ISSN 2079-6382