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Resistance to antibiotics is one of the main barriers to manage patients with bacterial infections worldwide, and the threat is increasing. It is well known that the inappropriate use of antibiotics at different levels is probably the driving source of resistance. This idea prompted the “One H...

Welcome to the Novel Antimicrobial Agents section. This section intends to cover and publish all aspects related to new antimicrobials. This section includes, but is not limited to, new antimicrobials, its modifications, new sources of antimicrobials, antimicrobial detection methods and alternative ...

One of the major challenges of the 21st century in biological sciences is the discovery of new molecules with antimicrobial properties and active on bacterial strains that are multi-resistant to the antibiotics currently available in our therapeutic arsenal. Peptides are a family of molecules that a...

Prokaryotic and eukaryotic cells are major players in providing novel antimicrobial molecules. The evolvement of antimicrobial discovery highly depends on understanding the molecular paths regulating the production of the target molecule. Such degree of understanding allows for advancing bio-based r...

Because of the continued process of evolution and natural selection with antimicrobials, bacterial pathogens are gaining the edge over human ingenuity and our collective ability to produce new antimicrobials and utilize existing antimicrobials wisely. While mechanisms of bacterial antibiotic resista...

The Section of Fungi and Their Metabolites publishes original research and review articles that report on fungal physiological properties, pathogenicity, ecology and molecular regulatory mechanisms, as well as fungal metabolites, including their functions and applications. The purpose of this Sectio...

Pharmacokinetics (PK) describes the concentration–time profile of a drug in the body, whereas pharmacodynamics (PD) relates drug exposure to its biological effects, such as the ability of an antibiotic to inhibit or kill bacteria. In simple terms, PK reflects what the body does to the drug, wh...

The ‘Plant-Derived Antibiotics’ Section of the journal Antibiotics publishes original research and review articles reporting on antimicrobial effects of phytochemicals. The purpose of this Section is to address the need for new and complementary antimicrobials from plant sources. In part...

An in-depth understanding of pathogenic microorganisms with respect to both genetics and biochemistry is important for the future treatment of infections. In this section, we welcome: Studies that use either genetics or biochemical assays to screen for novel antimicrobials Studies on host–...

The growing number of drug-resistant bacteria is an emerging global health crisis that requires alternative approaches. Current research indicates that bacteriophages (phages), viruses infecting bacteria, can represent a viable alternative, or be part of conventional antimicrobial therapy in combina...

Welcome to the novel Section Antibiofilm Strategies. This Section intends to cover and publish all aspects related to the control of biofilms. This field includes, among others, new antimicrobials active against microbes organized in biofilms, modifications of surfaces to prevent biofilm formation, ...

Antibiotics play a vital role in modern medicine. Their discovery and use after World War II significantly increased human life expectancy. They are used primarily to treat bacterial infections, but also sometimes used to prevent them, mainly in the surgical setting. From 1940 to 1990, the discover...

Huge amounts of antibiotics are administrated annually to almost all domestic animal species for treatment or prophylaxis of infectious diseases or as feed additives for their growth-promoting effect. Antibiotics are needed to fight infectious diseases caused by specific animal pathogens. The develo...

Welcome to the Section Antimicrobial Materials and Surfaces. This Section aims to cover and publish papers on all aspects related to the synthesis, characterization, and application of novel materials with antimicrobial properties. This Section includes but is not limited to the synthesis and charac...

The emerging problem of antimicrobial resistance poses a serious threat to public health around the world. Furthermore, this situation is exacerbated by the significant decline in antimicrobial research and development. Very few new classes of antimicrobials enter the market as older classes lose th...