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Diabetology, Volume 6, Issue 12

2025 December - 20 articles

Cover Story: Even with advanced diabetes technologies such as automated insulin delivery (AID), hypoglycemia in Type 1 diabetes remains influenced by exercise and other real-world factors. Previous research has explored the relationship between glycemic variability (GV) and hypoglycemia, but typically over short time windows, leaving limited understanding of how GV evolves over longer periods before and after hypoglycemic events. Using data from the T1DEXI dataset, this study analyzes CGM data over a 96-hour window (−48 to +48 hours) surrounding hypoglycemia to characterize GV and time below range. We compare AID and non-AID users and assesses potential related factors, including exercise, hypoglycemia duration and severity, and gender. Our findings indicate that GV and time below range can remain disrupted for up to 48 hours following hypoglycemia in both AID and non-AID users. View this paper
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Articles (20)

  • Article
  • Open Access
1 Citations
741 Views
12 Pages

Glucagon-like Peptide-1 Receptor Agonists and Survival in Advanced Chronic Kidney Disease and Type 2 Diabetes

  • Scott Reule,
  • Sean Pickthorn,
  • Stefanie Worwa,
  • Areef Ishani and
  • Robert Foley

Background/Objectives: In populations with type 2 diabetes mellitus (T2DM), it is unknown whether the survival benefits of glucagon-like peptide-1 receptor agonists (GLP-1 RA) differ by estimated glomerular filtration rate (eGFR). To address this que...

  • Correction
  • Open Access
239 Views
2 Pages

Correction: del Río Pascual et al. Therapeutic Adherence and Glycemic Control in the Population with Diabetes in Ceuta (Spain), a Multicultural City: A Cross-Sectional Study. Diabetology 2025, 6, 100

  • Brieba del Río Pascual,
  • Antolí Jover Ana María,
  • Vázquez Lara Juana María,
  • Ruger Navarrete Azahara,
  • Vázquez Lara María Dolores,
  • Palomo Gómez Rocio,
  • Artero García Alejandro,
  • Rodríguez Díaz Luciano and
  • Fernández Carrasco Francisco Javier

Text Correction [...]

  • Article
  • Open Access
609 Views
14 Pages

Knowledge and Self-Efficacy as Key Determinants of Transition Readiness in Adolescents with Type 1 Diabetes: Insights from Adolescents, Parents, and Clinicians

  • Ailsa Marshall,
  • Nghi H. Bui,
  • Ann Nillsen,
  • Lena Lim,
  • Gillian Burke,
  • Amelia Christie,
  • Sandeep Kaur,
  • Karina Pearce,
  • Jack Ho and
  • Shihab Hameed
  • + 8 authors

Aim: Assess transition readiness of adolescents with Type 1 Diabetes (T1D) from adolescent, parental, and clinician perspectives. Methods: Cross-sectional study (n = 36, 20 Male/16 Female, 16–18 years, June 2023–June 2024, metropolitan pa...

  • Article
  • Open Access
1,000 Views
17 Pages

Objective: The aim was to characterize the real-world use of GLP-1 receptor agonists (GLP-1 RAs) and/or SGLT2 inhibitors in kidney transplant recipients (KTRs) with diabetes and to compare the clinical management, safety, and effectiveness between pa...

  • Article
  • Open Access
416 Views
11 Pages

Implementing the Physical Activity Vital Sign in a Pediatric Diabetes Center

  • Margaret M. McCarthy,
  • Jeniece Ilkowitz,
  • Jinyu Hu and
  • Mary Pat Gallagher

Aims: The purpose of this quality improvement (QI) initiative at a pediatric diabetes center was to integrate physical activity (PA) assessment into routine clinical care. This project had two aims: (1) to collect self-reported PA in youth and young...

  • Article
  • Open Access
718 Views
21 Pages

Background: Managing Type 1 diabetes (T1D) aims to optimize glucose within the target range while minimizing hyperglycemia and hypoglycemia, yet exercise complicates glycemic outcomes. Despite advances, evidence is limited on how exercise relates to...

  • Essay
  • Open Access
679 Views
10 Pages

Introduction: Advancements in diabetes technology have transformed diabetes management, yet technology implementation remains inconsistent due to barriers at both the clinician and patient levels. Team-based collaborative care offers a promising stra...

  • Article
  • Open Access
744 Views
13 Pages

The Role of Social Determinants of Health and Diabetes Self-Management on Glycemic Indices: A Cross-Sectional Analysis

  • Cherlie Magny-Normilus,
  • Sangchoon Jeon,
  • Jeffrey L. Schnipper,
  • Bei Wu and
  • Robin Whittemore

Background/Objectives: Type 2 diabetes (T2D) is a substantial health burden on foreign-born Haitian Americans (FBHAs) in the United States, who experience poorer health outcomes for T2D, in particular, cardiovascular disease and diabetes nephropathy....

  • Article
  • Open Access
391 Views
9 Pages

Visual Acuity and Beyond: Sociodemographic Determinants of Quality of Life in Diabetic Retinopathy

  • Elitsa Hristova,
  • Lidiya Zaduryan,
  • Gabriela Vasileva,
  • Iliyana Petkova,
  • Mladena Radeva and
  • Zornitsa Zlatarova

Background: Diabetic retinopathy (DR) is a leading cause of vision-related disability worldwide. Evidence on how clinical and sociodemographic factors jointly shape vision-related quality of life (VRQoL) in Eastern European settings remains limited....

  • Review
  • Open Access
1,117 Views
20 Pages

Complications and Comorbidities in Individuals >80 Years with Diabetes: A Scoping Review

  • Christian Ward-Bradley,
  • Adam Erwin,
  • Tunde Peto,
  • Laura N. Cushley and
  • Katie Curran

Background/Objectives: Diabetes mellitus is increasingly prevalent among adults aged over 80 years; however, this population remains substantially underrepresented in clinical research on diabetes complications. This scoping review synthesises curren...

  • Article
  • Open Access
827 Views
11 Pages

Perinatal Outcomes of Type 1 and Type 2 Diabetes in Pregnancy: A 10-Year Single-Centre Cohort Study

  • Paul Lawton,
  • Jean Lu,
  • Ryan Endall,
  • Jing Luo,
  • Rebecca Foskey,
  • Dev Kevat,
  • Peter S. Hamblin,
  • Joanne M. Said,
  • Glyn Teale and
  • I-Lynn Lee
  • + 1 author

Background/Objectives: Previous studies have examined perinatal outcomes in women with type 1 (T1DM) or type 2 diabetes (T2DM) in pregnancy compared with the general population, but few have directly assessed the impact of T1DM and T2DM on pregnancy...

  • Article
  • Open Access
628 Views
11 Pages

Diabetes Mellitus and the Increased Risk of Acute Kidney Injury Following Acute Coronary Syndrome

  • Muhammad Usman Shah,
  • Paul Edward Squires,
  • Claire Elizabeth Hills and
  • Kelvin Lee

Background/objectives: Diabetes mellitus (DM) increases susceptibility to both cardiovascular and renal complications. Acute kidney injury (AKI) in the setting of acute coronary syndrome (ACS) is a frequent manifestation of acute cardiorenal syndrome...

  • Article
  • Open Access
934 Views
18 Pages

Background: Metabolic syndrome (MetS) comprises a cluster of metabolic abnormalities that increase the risk of type 2 diabetes mellitus (T2DM) and cardiometabolic morbidity. Although widely recognized, evidence on its documentation and follow-up in p...

  • Article
  • Open Access
636 Views
12 Pages

Background/Objective: Type 2 diabetes mellitus (T2DM) is a known risk factor for cardiovascular disease (CVD); however, not all individuals with T2DM have the same CVD risk. Traditional glycemic cluster analyses of individuals with diabetes using the...

  • Article
  • Open Access
470 Views
10 Pages

Exploring the Relationship Between Health Biomarkers and Performance on a Novel Color Perimetry Device in Prediabetes and Type 2 Diabetes

  • Liam Burhans,
  • Bismark Owusu-Afriyie,
  • Christopher S. Wu,
  • Jennyffer D. Smith,
  • Daniel R. Coates and
  • Wendy W. Harrison

Background/Objectives: Type 2 diabetes (T2DM) is a leading cause of vision loss. Functional measurements (color vision and contrast sensitivity) are sensitive to early changes in eyes even before retinopathy is present. This study evaluates a novel c...

  • Article
  • Open Access
608 Views
11 Pages

A Real-World Comparison of Three Deep Learning Systems for Diabetic Retinopathy in Remote Australia

  • Jocelyn J. Drinkwater,
  • Qiang Li,
  • Kerry Woods,
  • Emma Douglas,
  • Mark Chia,
  • Yukun Zhou,
  • Steve Bartnik,
  • Yachana Shah,
  • Vaibhav Shah and
  • Angus W. Turner
  • + 1 author

Background/objective: Deep learning systems (DLSs) may improve access to screening for diabetic retinopathy (DR), a leading cause of vision loss. Therefore, the aim was to prospectively compare the performance of three DLSs, Google ARDA, Thirona RetC...

  • Review
  • Open Access
1,430 Views
20 Pages

From Classic to Contemporary, Evolving Therapies in Diabetic Kidney Disease: The Point of View of the Nephrologist and the Diabetologist

  • Micaela Gentile,
  • Marta D’Angelo,
  • Maria Rosaria Varì,
  • Andrea Mario Bolla,
  • Maurizio Bianco and
  • Roberto Scarpioni

Diabetes mellitus represents a global health concern, which is expected to worsen over the years. The prevalence is estimated to increase up to 642 million people by 2040. Almost half of diabetic patients are at a high risk of developing kidney invol...

  • Article
  • Open Access
719 Views
11 Pages

Background/Objectives: Diabetic nephropathy is the leading cause of end-stage kidney disease (ESKD) worldwide. ESKD individuals with type 2 diabetes are known to have poor prognosis of survival. We aimed to investigate whether the recent mortality tr...

  • Brief Report
  • Open Access
631 Views
14 Pages

The Von Hippel–Lindau Protein (pVHL) Is Downregulated in the Pancreatic Islets of Mice with Type 2 Diabetes Induced by a High-Calorie Diet

  • Alma Nelly Diaz-Herreros,
  • Alberto Granados-Galeana,
  • Isaí Martínez-Torres,
  • Elba Reyes-Maldonado,
  • Erika Rosales-Cruz,
  • Fernando Gómez-Chávez,
  • Gabriel Betanzos-Cabrera,
  • Amaranta Sarai Valdez-Guerrero,
  • Juan Carlos Cancino-Diaz and
  • Mario Eugenio Cancino-Diaz

27 November 2025

Background/Objectives: Knock-out mice lacking von Hippel–Lindau protein (pVHL) in pancreatic beta cells exhibit glucose intolerance and low insulin production, indicating a possible association between pVHL and diabetes mellitus (DM). It is cur...

  • Article
  • Open Access
827 Views
18 Pages

Semaglutide Therapy and Cardiorenal Risk Management in Type 2 Diabetes: hsCRP as a Biomarker of Risk

  • Nikolay Krasimirov Kostadinov,
  • Tcvetelina Totomirova and
  • Boyan Ivanov Nonchev

25 November 2025

Background: Inflammation plays a key role in the pathogenesis of type 2 diabetes (T2D) and the associated cardiovascular complications. High-sensitivity C-reactive protein (hsCRP) is a widely used marker of systemic inflammation as well as a predicto...

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Diabetology - ISSN 2673-4540