2026 August - 24 articles
Background: The development of osteoarthritis (OA), a whole-joint disorder that is increasingly recognized, depends on subchondral trabecular bone. Variations in the viscoelastic characteristics of trabecular bone have been proposed to affect load di...
In recent years, advancements in gene therapy have highlighted the important role of adeno-associated viruses (AAVs) due to their favorable characteristics, such as low immunogenicity compared to other viral vectors, e.g., lentivirus and HSV, and the...
This study investigated the effects of terpene compounds from Schinus molle fruit essential oil (EO) against osteoarthritis (OA) using integrated network pharmacology, molecular docking, and molecular dynamics. The EO, obtained by steam distillation...
Mesenchymal stem cells (MSCs) have become a focus of regenerative medicine research due to their potential utility in treating a variety of musculoskeletal disorders. Multiple qualities make them an ideal candidate to address musculoskeletal structur...
Molecular docking was used to investigate the interactions between tirapazamine (a bioreductive anticancer drug) and bovine serum albumin (BSA), with emphasis on binding site localization and geometry. Docking simulations were performed using SwissDo...
There is a growing interest in methods that illuminate the contributions of individual positions to a protein’s function by site-saturating mutagenesis. However, a commonly used approach for assessing variant libraries with deep mutational scan...
This study investigated the distribution and dispersion of Sc-47 (47Sc), a β-emitting radionuclide that can be produced in large quantities using accelerators. As the stability of labeled compounds inside the body is essential for nuclear medici...
We herein report the anticancer activity and molecular docking studies of a series of amide derivatives of two nonsteroidal anti-inflammatory drugs (mefenamic acid and ibuprofen). The hypothesis of drug repurposing has been successfully employed to e...
Streptococcus pneumoniae is the major causative agent of community-acquired pneumonia, one of the main infectious diseases that causes inflammation in the alveoli and leads to significant morbidity and mortality across various age groups. Current tre...
Metastatic spinal cord compression (MSCC) requires urgent radiotherapy. However, selecting the optimal technique that balances dosimetric precision with treatment efficiency remains clinically challenging. This study compares four radiotherapy modali...
Voltage-sensitive ion channels are glycoprotein macromolecules that carry ion currents across membranes of nerve and muscle fibers. The hypothesis presented helps explain the changes that convert an insulating ion channel into an ion conductor, stati...
Large language models (LLMs) are increasingly applied across drug discovery, yet their role in analytical method development to support quality control in cell-based potency assays remains insufficiently explored. This study evaluates whether general...
In-vivo diabetes detection of glucose was sought using square-wave anodic stripping voltammetry (SW), with bismuth-immobilized carbon nanotube paste electrode (BCE), and skin tattoo painted wearable circuits. The optimum analytical results indicated...
In this work, we present a novel framework of integrating anthropometric measurement with posture recognition using LabVIEW’s Vision Development Module specifically for yoga poses. Yoga is a practice that originated in India many years ago and...
Functional gastrointestinal disorders (FGIDs) affect over 40% of the global population and represent a substantial health and economic burden. Gandhaga Dravagam (GD) is a classical Siddha mineral-based distillate prepared from sulfur, potassium nitra...
The electrical behavior of cellular membranes plays a fundamental role in neuronal communication and in many physiological processes involving excitable cells. Mathematical modeling has become an essential tool for understanding the physical mechanis...
It was recently postulated that neural microtubules (neuro-MTs), which are densely packed inside axons and dendrites, are vacuum cylindrical nanotubes that can mediate neuroelectrical transmission with a unique form of quasi-superconductivity. In thi...
Quantifying the spatial distribution of immune cells within intact skin tissue is essential for understanding diseases such as vitiligo, in which CD8+ T cells selectively destroy epidermal melanocytes within the discrete, parallelogram-shaped epiderm...
Musculoskeletal pain is driven by degenerative conditions such as osteoarthritis or intervertebral disk degeneration. This creates a major burden on health systems and patient quality of life. Platelet-rich plasma (PRP) is an orthobiologic that conta...
Developing advanced bioinspired photoprotective barrier from marine resources represents a critical frontier of bioprocessing. This study established a rational design and implementation of effective photoprotective surface-coating eumelanin from ink...
In this study, we investigate how lightning-derived electric-field influences nonlinear excitation dynamics in excitable systems. Cloud-to-ground (CG) lightning observations from the National Lightning Detection Network (NLDN), including event time,...
Localized optical absorption by nanoscale inclusions can profoundly alter energy deposition in optical traps, giving rise to nonlinear and long-timescale dynamics. Recent experiments have reported the formation of expanding optically darkened regions...
The continuous evolution of the SARS-CoV-2 virus, marked by the emergence of new variants, poses a significant threat to the efficacy of existing vaccines. However, a promising approach to addressing vaccine failure caused by viral mutations (particu...
In therapeutic applications, ultrasound is widely used in physiotherapy, tissue repair, and cancer treatment. Regarding cancer treatment, as an emerging field for technology, significant research efforts have been devoted to the area of ultrasound th...
