New Insights into Cytoskeleton

Topic Information

Dear Colleagues,

The cytoskeleton consists of microtubules, microfilaments, and intermediate filaments. In prokaryotic and eukaryotic cells (plants and animals), the cytoskeleton supports cell and organelle structure, facilitates cell movement, phagocytosis, cell adhesion, cell division, and chromosome separation, and transmits environmental signals to the cell. It regulates organellar fission and fusion, vesicular trafficking, and receptor recycling. In immune cells, the cytoskeleton regulates cell–cell interactions and immune response. The cytoskeleton and its molecular motors regulate the localization of coding and noncoding RNAs and proteins to specific destinations. The nuclear cytoskeleton supports nucleus morphology and shape and controls chromatin compaction, transcription, double-strand break mobility, and repair. Viruses and bacteria hijack the cytoskeleton for propagation, movement within the cell, and spreading between cells. For this Topic, we invite reviews and original papers detailing research on the cytoskeleton in animal and plant cells.

Prof. Dr. Malgorzata Kloc
Dr. Jacek Z. Kubiak
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Biophysica biophysica	1.4	2.3	2021	22.9 Days	CHF 1200	Submit
Current Issues in Molecular Biology cimb	3.0	3.7	1999	17.8 Days	CHF 2200	Submit
Biology biology	3.5	7.4	2012	17.4 Days	CHF 2700	Submit
Membranes membranes	3.6	7.9	2011	17 Days	CHF 2200	Submit
International Journal of Molecular Sciences ijms	4.9	9.0	2000	20.5 Days	CHF 2900	Submit

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Published Papers (1 paper)

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25 pages, 9187 KiB  

Open AccessArticle

The Plus End-Directed Microtubule (Kinesin-3 Family) Motor Protein KIF13B Is Associated with the Photoreceptor Synaptic Ribbon Complex

by Shweta Suiwal, Karin Schwarz, Stephan Maxeiner and Frank Schmitz

Int. J. Mol. Sci. 2025, 26(13), 6044; https://doi.org/10.3390/ijms26136044 - 24 Jun 2025

Viewed by 244

Abstract

Retinal ribbon synapses are continuously active chemical synapses. The eponymous synaptic ribbon is anchored to the active zone neurotransmitter release sites of ribbon synapses, recruits synaptic vesicles and guides ribbon-associated synaptic vesicles to the release sites. RIBEYE is the major protein component of [...] Read more.

Retinal ribbon synapses are continuously active chemical synapses. The eponymous synaptic ribbon is anchored to the active zone neurotransmitter release sites of ribbon synapses, recruits synaptic vesicles and guides ribbon-associated synaptic vesicles to the release sites. RIBEYE is the major protein component of synaptic ribbons. But likely, additional proteins contribute to ribbon synapse function. The synaptic ribbon of photoreceptor synapses is embedded into a highly polarized microtubule cytoskeleton. Interestingly, proteins of the photoreceptor primary cilium, such as NPHP4 and other ciliary proteins, including KIF3A, were shown to be localized to photoreceptor synaptic ribbons. Previous studies demonstrated that the microtubule motor protein KIF13B catalyzes secretory vesicle transport to the plus ends of microtubules and identified an interaction of KIF13B with NPHP4 at primary cilia. However, the localization of KIF13B, a kinesin-3 family motor protein, in the retina is still unknown. In the present study, we used two different antibodies against KIF13B and high-resolution confocal microscopy, super-resolution structured illumination microscopy (SR-SIM), and post-embedding immunogold electron microscopy to determine the localization of KIF13B in retinal photoreceptors. Apart from its localization at the primary photoreceptor cilium, we found a strong enrichment of KIF13B at photoreceptor synaptic ribbons. The synaptic ribbon is needed for the synaptic enrichment of KIF13B as shown by analyses of synaptic ribbon-deficient RIBEYE knockout mice. These findings suggest that KIF13B performs vesicle trafficking functions at the photoreceptor synaptic ribbon complex at the interface between the synaptic ribbon and the presynaptic microtubule transport system. Full article

(This article belongs to the Topic New Insights into Cytoskeleton)

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