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Separations, Volume 13, Issue 7

2026 July - 24 articles

Cover Story: Acetonitrile and trifluoroacetic acid remain the standard eluents for preparative peptide purification, delivering high purity and yield in batch chromatography but concurrently raising environmental and safety concerns. Processes involving green alternatives such as ethanol and acetic acid struggle to match this performance in batch mode. MCSGP (multi-column counter-current solvent gradient purification) with AutoPeak bridges this gap, enabling green solvents to deliver high performance without sacrificing purity or yield. Green MCSGP matches conventional ACN/TFA batch results while improving productivity and reducing solvent consumption. With its high automation, proven scalability, and dynamic process control via AutoPeak, MCSGP offers a practical path to replacing toxic and persistent chemicals at industrial scale. View this paper
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Articles (24)

  • Article
  • Open Access
464 Views
19 Pages

Separation Effect and Hydrodynamic Parameters of an Ilmenite–Chlorite Slurry in Spirals via Cross-Sectional Geometry Regulation of Middle Trough

  • Shuling Gao,
  • Xintong Zhang,
  • Qian Wang,
  • Xiaohong Zhou and ,
  • Chunyu Liu,
  • Guixia Fan and
  • Daoguang Teng
  • + 2 authors+ 0 author

The middle trough of spirals serves simultaneously as a buffer zone for variations in hydrodynamic parameters and as a region where mineral particles of different densities are prone to mixing, exerting a profound influence on particle-separation eff...

  • Article
  • Open Access
424 Views
16 Pages

Y-Site Compatibility of Doxapram Hydrochloride with Commonly Used Drugs in the NICU

  • Mao Maekawa,
  • Masamitsu Maekawa,
  • Yu Sato,
  • Shimpei Watanabe and ,
  • Masatoshi Saito and
  • Nariyasu Mano
  • + 1 author+ 0 author

In neonatal intensive care units (NICUs), limited vascular access often necessitates the co-administration of multiple intravenous medications through a single line, increasing the risk of physicochemical incompatibility. Doxapram hydrochloride (DOP)...

(This article belongs to the Special Issue Application of Chromatographic Techniques for the Determination of Active Pharmaceutical Compounds)
  • Review
  • Open Access
2,271 Views
47 Pages

Per- and polyfluoroalkyl substances (PFASs) are persistent environmental contaminants widely recognized as “forever chemicals” due to the exceptional stability of their carbon–fluorine (C-F) bonds. Their widespread occurrence in wat...

(This article belongs to the Special Issue Recent Advances in Adsorption and Degradation Technologies of Per- and Polyfluoroalkyl Substances (PFAS))
  • Editorial
  • Open Access
328 Views
2 Pages

Biomedical research has undergone profound changes in recent years, driven by advances in analytical technologies that enable the investigation of increasingly complex biological systems [...]

(This article belongs to the Section Advanced Separation Science in Biomedical Research and Clinical Applications)
  • Article
  • Open Access
497 Views
17 Pages

Biodegradable Nanofiber Membrane with Designed Beaded Structure for High-Efficiency Oil–Water Separation

  • Linlin Yan,
  • Jinglin Hong,
  • Jialing Zhang,
  • Yanying Zhao and ,
  • Yuqian He,
  • Kai Wang,
  • Yuhua Gao,
  • Zongli Xie and
  • Xiquan Cheng
  • + 4 authors+ 0 author

Membrane separation technology has been extensively applied to treat oily effluent given its high performance and ease of operation. However, conventional polymer membranes are resistant to natural degradation after use, leading to severe environment...

(This article belongs to the Section Environmental Separations)
  • Article
  • Open Access
1 Citations
500 Views
17 Pages

Green Separation of Scandium and Titanium Using Citric Acid via Organic Complexation Scrubbing

  • Guangyu Zhang,
  • Weiguang Zhang,
  • Yingxuan Wang,
  • Lexuan Zhang and ,
  • Xuejiao Cao,
  • Yibing Li,
  • Yang Chen and
  • Yan Wang
  • + 3 authors+ 0 author

Aiming at the bottleneck of the difficult scrubbing and separation of scandium and titanium in the solvent extraction process for scandium recovery, a novel strategy for scandium–titanium separation via citrate complex scrubbing is proposed bas...

(This article belongs to the Topic Advances in Solvent Extraction)
  • Article
  • Open Access
616 Views
16 Pages

Water–Induced Spherical Crystallization of Pantoprazole Sodium

  • Yikai Chen,
  • Zhiying Pan,
  • Hongcheng Li,
  • Shichao Du and ,
  • Yan Wang and
  • Fumin Xue
  • + 1 author+ 0 author

This study develops a spherical crystallization approach using a small amount of water, which avoids adding extra bridging agents. Notably, a new ternary solvate of pantoprazole sodium (PS–BuOH–H2O) was obtained, and its crystal structure...

(This article belongs to the Special Issue Emerging New Technologies in Fundamental and Industrial Crystallization)
  • Article
  • Open Access
901 Views
30 Pages

Innovating Slow Sand Filtration: Exploring the Regeneration of a Traditional Technology for the 21st Century

  • Hayley Corbett,
  • Brian Solan,
  • Svetlana Tretsiakova-McNally,
  • Pilar Fernandez-Ibañez and ,
  • Bárbara Luíza Souza Freitas and
  • Rodney McDermott
  • + 1 author+ 0 author

The intensifying rate of global water stress is motivating the exploration of alternative water sources. This research aims to unlock conventionally unusable wastewater effluent for reuse with the aid of slow sand filtration (SSF). In this study, a t...

(This article belongs to the Special Issue Sustainable and Intelligent Process Control of Pollutant Separation and Purification)
  • Article
  • Open Access
1 Citations
612 Views
25 Pages

A Novel Photo-Responsive Molecularly Imprinted Silica as a Sustainable Solid-Phase Extraction Filler for Highly Selective Adsorption of Chlorogenic Acid

  • Ying Yang,
  • Xiaofei Xie,
  • Jingchang Zhang,
  • Jirui Sui and ,
  • Chuancheng Lin,
  • Mingxing Li,
  • Weixue Liu,
  • Chunying Li and
  • Chunjian Zhao
  • + 4 authors+ 0 author

Chlorogenic acid (CA) is an important natural antioxidant component and holds strong potential for health food and cosmetic applications. In this study, a silica-based photo-responsive molecular imprinting material (PMI-PDA@NH2-SiO2) was designed as...

  • Review
  • Open Access
1 Citations
1,168 Views
20 Pages

With the widespread application of new chemicals, the concentration of emerging contaminants (ECs), such as antibiotics, per- and polyfluoroalkyl substances (PFAS), microplastics, and new pesticides, in aquatic environments is on the rise. ECs such a...

(This article belongs to the Special Issue Application of Adsorption and Separation Technologies in Water Treatment)
  • Article
  • Open Access
650 Views
21 Pages

Coal gasification slag (CGS), a massive industrial solid waste, possesses inherent adsorptive potential that remains underutilized due to pore blockage by amorphous siliceous phases. Conventional modification strategies typically rely on energy-inten...

(This article belongs to the Special Issue Solid Waste Recycling and Strategic Metal Extraction)
  • Article
  • Open Access
583 Views
12 Pages

Rapid Determination of 45 Pigments and Preservatives in Edible Ink by Ultra-High Performance Liquid Chromatography Coupled with Triple Quadrupole Tandem Mass Spectrometry

  • Zhuowen Feng,
  • Jieshan Wu,
  • Tingwei Huang,
  • Liang Pan and ,
  • Yue Zhao,
  • Yun Cui,
  • Shiwei Ren and
  • Abderrahim Yassar
  • + 3 authors+ 0 author

An analytical method was established for the rapid determination of 45 pigments and preservatives in edible ink by ultra-high performance liquid chromatography coupled with triple quadrupole tandem mass spectrometry (UHPLC-MS/MS), which provides tech...

(This article belongs to the Topic Advances in Chromatographic Separation)
  • Review
  • Open Access
1 Citations
1,194 Views
25 Pages

Advancing Iron Recovery from Red Mud: Green Pathways, Synergistic Valorization, and High-Value Total Component Utilization

  • Guoqiang Liang,
  • Chenpeng Wang,
  • Qianwei Ji,
  • Xusheng Zhang and ,
  • Liang Zhao,
  • Xinchun Liu,
  • Zhisheng Yu,
  • Hongxun Zhang,
  • Guoqiang Zhuang and
  • Ruyin Liu
  • + 6 authors+ 1 author

Facing the severe environmental challenge of massive red mud (RM) stockpiles, iron extraction research is accelerating from traditional pyrometallurgy and other conventional processes toward green low-carbon, multi-source synergistic, and total-compo...

(This article belongs to the Special Issue Separation and Extraction Technology in Mineral Processing: Second Edition)
  • Article
  • Open Access
2,029 Views
17 Pages

Counter-Current Chromatography Enables Use of Green Solvents for Productive Peptide Purification Processes

  • Rosella Prestia,
  • Damian Hauri,
  • Mattia Sponchioni,
  • Sebastian Vogg and
  • Thomas Müller-Späth

Peptide purification by preparative reversed-phase liquid chromatography remains one of the most resource-intensive stages in synthetic peptide manufacturing. Production processes commonly rely on acetonitrile/trifluoroacetic acid (ACN/TFA) mobile ph...

(This article belongs to the Special Issue Advanced Separation Media and Technologies for Biomolecules)
  • Article
  • Open Access
787 Views
30 Pages

Analysis of the Characteristic Chromatogram and Quantitative Determination of 25 Marker Compounds in the Traditional Chinese Medicine Preparation Qili Qiangxin Capsules by HPLC-DAD-ESI-MS/MS

  • Xin-Wen Huang,
  • Xiang Li,
  • Yi-Jing Lang,
  • Ran-Xu Song and ,
  • Jing-Jing Ren,
  • Yan-Hua Xie,
  • Hui-Min Xiao and
  • Si-Wang Wang
  • + 3 authors+ 0 author

To establish a comprehensive quality control method for Qili Qiangxin Capsules, an HPLC-DAD-ESI-MS/MS approach was developed for characteristic chromatogram analysis, marker compound identification, and multi-compound quantification. Similarity analy...

  • Article
  • Open Access
357 Views
18 Pages

Magnetic Co-Al Layered Double Hydroxides as Peroxymonosulfate Activator for the Removal of Pesticide Multiresidues

  • Zi-Ying Zeng,
  • Cheng-Xiang He,
  • Qin Tian,
  • Jun Long and ,
  • Bing-Yan Du,
  • Er-Cheng Zhao and
  • Zhong-Hua Yang
  • + 2 authors+ 0 author

The increasing prevalence of multiclass pesticide residues in aquatic environments poses a significant threat to ecosystems and human health. To address this challenge, magnetic Fe3O4@Co5Al-LDH nanoparticles were synthesized as high-performance, easi...

(This article belongs to the Special Issue New Techniques for Extraction and Removal of Pesticide Residues)
  • Article
  • Open Access
432 Views
16 Pages

Study of the Dynamic Characteristics of Simulated Droplet Particles in Hydro-Jet Cyclone Based on CFD-DPM

  • Yao Zhang,
  • Yong Yu,
  • Zhi-Bin Zhou,
  • Zheng-Hao Yang and ,
  • Yu-Long Chang,
  • Li-Wang Wang and
  • Ben-Shuai Guo
  • + 2 authors+ 0 author

The complex behavior of multi-scale droplets in Hydro-jet Cyclone (HJC) systems constrains the parametric study of gas–liquid separation and interfacial transfer. To investigate droplet dynamics at a specific scale in swirling flows, this study...

(This article belongs to the Section Environmental Separations)
  • Article
  • Open Access
445 Views
13 Pages

Coal plays a vital role in energy production, but its combustion releases SO2, causing serious environmental problems. In this study, indigenous microorganisms with sulfur-metabolism potential were isolated from raw coal and evaluated for coal biodes...

(This article belongs to the Section Purification Technology)
  • Article
  • Open Access
802 Views
21 Pages

Intensified Roasting at Low-Temperature and Alkaline Leaching to Efficiently Remove Harmful Elements for Green Utilization of Secondary Aluminum Dross

  • Nianzi Liu,
  • Yilin Wang,
  • Qing Long,
  • Anyan Long and ,
  • Guihua Liu,
  • Tiangui Qi,
  • Qiusheng Zhou,
  • Leiting Shen and
  • Jian Guo
  • + 4 authors+ 0 author

Secondary aluminum dross (SAD) from the aluminum industry is a hazardous residue that restricts sustainable aluminum production. Residual aluminum nitride (AlN) and insoluble fluorides after conventional pretreatment are major barriers to the safe ut...

(This article belongs to the Special Issue Innovative Separation Techniques for Sustainable Recycling of Solid Waste)
  • Article
  • Open Access
366 Views
20 Pages

Ionic liquid-assisted extraction can improve the recovery of monoterpene glycosides from Radix Paeoniae Alba, whereas post-extraction purification and ionic-liquid-associated marker-level quality control remain necessary before further bioactivity ev...

  • Review
  • Open Access
1,215 Views
28 Pages

Research in the analytical and preparative fields of separation science has a long-standing tradition in the Czech Republic and former Czechoslovakia. Czech and Slovak scientists recognized the advantages of the two most widely used separation techni...

(This article belongs to the Collection CEGSS Yesterday, Today and Tomorrow)
  • Article
  • Open Access
1,377 Views
15 Pages

This study investigated the effect of ethanol on the relative headspace percent composition of evaporative emissions from gasoline at different temperatures using HS-SPME-GC-MS. The results showed that the relative abundance of monoaromatics in the h...

(This article belongs to the Section Separation Science in Energies)
  • Article
  • Open Access
417 Views
20 Pages

Valorization of Phosphate Tailings into Ca-Mg-Al Layered Double Hydroxides for Phosphate Adsorption from Wastewater

  • Zhe Wang,
  • Hongquan Jing,
  • Bingbing Liu,
  • Yixuan Zhang and ,
  • Jiangli Li and
  • Cuihong Hou
  • + 1 author+ 0 author

Phosphate tailings (PTs), a solid waste generated from phosphate flotation, are a low-grade phosphate resource rich in quartz and dolomite. Their long-term accumulation leads to both resource loss and environmental risks, making valorization increasi...

(This article belongs to the Special Issue New Approaches to Phosphorus Pollutant Control and Phosphorus Recovery)
  • Article
  • Open Access
776 Views
9 Pages

212Pb is an important medical radionuclide for targeted alpha therapy, and its reliable supply depends on the efficient production of parent nuclides such as 228Ra, 228Th, and 224Ra. Natural thorium resources are abundant and represent a potential so...

(This article belongs to the Section Separation Engineering)
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Separations - ISSN 2297-8739