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Biomedicines, Volume 10, Issue 8

August 2022 - 288 articles

Cover Story: TTR is a tetrameric protein synthesised by the liver and the choroid plexus (CP). Destabilization of the TTR structure leads to amyloid depositions in the heart and nervous system. TTR can be synthetised and released both as free tetramers or complexed with one or two retinol-binding proteins (RBP). Free tetramers might be cleared by hepatocytes more efficiently than the complexed one, so the balance between TTR and RBP–TTR cannot be foreseen. The clearance has been studied only for the free form, so it is not known if the presence of RBP could affect it. Tissue sites of TTR degradation are the same for the liver or CP synthetised protein. The knowledge of the physiological turnover of TTR is the basis on which to identify the conditions involved in the onset and progression of organ TTR amyloidosis. View this paper
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Articles (288)

  • Article
  • Open Access
19 Citations
2,766 Views
19 Pages

Production of Reactive Oxygen Species by Epicardial Adipocytes Is Associated with an Increase in Postprandial Glycemia, Postprandial Insulin, and a Decrease in Serum Adiponectin in Patients with Severe Coronary Atherosclerosis

  • Natalia V. Naryzhnaya,
  • Olga A. Koshelskaya,
  • Irina V. Kologrivova,
  • Tatiana E. Suslova,
  • Olga A. Kharitonova,
  • Sergey L. Andreev,
  • Alexander S. Gorbunov,
  • Boris K. Kurbatov and
  • Alla A. Boshchenko

Purpose. This work investigates the relations between the production of reactive oxygen species (ROS) by epicardial adipose tissue (EAT) adipocytes and parameters of glucose/insulin metabolism, circulating adipokines levels, and severity of coronary...

  • Article
  • Open Access
4 Citations
3,568 Views
12 Pages

Aim: To study the predominant serum responses (antibodies IgG, IgA, IgE) against H. pylori in relation to the indicators of the system “lipid peroxidation–antioxidant system” in various pathogenetic variants of chronic gastritis (CG...

  • Article
  • Open Access
15 Citations
4,031 Views
34 Pages

Mutational Slime Mould Algorithm for Gene Selection

  • Feng Qiu,
  • Pan Zheng,
  • Ali Asghar Heidari,
  • Guoxi Liang,
  • Huiling Chen,
  • Faten Khalid Karim,
  • Hela Elmannai and
  • Haiping Lin

A large volume of high-dimensional genetic data has been produced in modern medicine and biology fields. Data-driven decision-making is particularly crucial to clinical practice and relevant procedures. However, high-dimensional data in these fields...

  • Review
  • Open Access
24 Citations
19,649 Views
96 Pages

A Historical Review of Military Medical Strategies for Fighting Infectious Diseases: From Battlefields to Global Health

  • Roberto Biselli,
  • Roberto Nisini,
  • Florigio Lista,
  • Alberto Autore,
  • Marco Lastilla,
  • Giuseppe De Lorenzo,
  • Mario Stefano Peragallo,
  • Tommaso Stroffolini and
  • Raffaele D’Amelio

The environmental conditions generated by war and characterized by poverty, undernutrition, stress, difficult access to safe water and food as well as lack of environmental and personal hygiene favor the spread of many infectious diseases. Epidemic t...

  • Article
  • Open Access
8 Citations
3,118 Views
10 Pages

Adverse Neonatal Outcome of Pregnancies Complicated by Preeclampsia

  • Piotr Tousty,
  • Magda Fraszczyk-Tousty,
  • Joanna Ksel-Hryciów,
  • Beata Łoniewska,
  • Joanna Tousty,
  • Sylwia Dzidek,
  • Kaja Michalczyk,
  • Ewa Kwiatkowska,
  • Aneta Cymbaluk-Płoska and
  • Andrzej Torbé
  • + 1 author

Despite many available treatments, infants born to preeclamptic mothers continue to pose a serious clinical problem. The present study focuses on the evaluation of infants born to preeclamptic mothers for the occurrence of early-onset complications a...

  • Article
  • Open Access
16 Citations
3,243 Views
10 Pages

Hashimoto’s Thyroiditis Minimizes Lymph Node Metastasis in BRAF Mutant Papillary Thyroid Carcinomas

  • Peter P. Issa,
  • Mahmoud Omar,
  • Yusef Buti,
  • Chad P. Issa,
  • Bert Chabot,
  • Christopher J. Carnabatu,
  • Ruhul Munshi,
  • Mohammad Hussein,
  • Mohamed Aboueisha and
  • Mohamed Shama
  • + 3 authors

Hashimoto’s thyroiditis (HT) (autoimmune thyroiditis) is a clinicopathological entity associated with chronic lymphocytic infiltration resulting in hypothyroidism. HT is a double-edged sword that increases the risk of papillary thyroid cancer (...

  • Article
  • Open Access
6 Citations
2,938 Views
10 Pages

Cerebrospinal fluid (CSF) hypovolemia is the core of spontaneous intracranial hypotension (SIH). More than 1000 magnetic resonance myelography (MRM) images are required to evaluate each subject. An effective spinal CSF quantification method is needed...

  • Review
  • Open Access
23 Citations
6,266 Views
21 Pages

Diagnostic and Therapeutic Potential of Circulating-Free DNA and Cell-Free RNA in Cancer Management

  • Sadia Hassan,
  • Adeeb Shehzad,
  • Shahid Ali Khan,
  • Waheed Miran,
  • Salman Khan and
  • Young-Sup Lee

Over time, molecular biology and genomics techniques have been developed to speed up the early diagnosis and clinical management of cancer. These therapies are often most effective when administered to the subset of malignancies harboring the target...

  • Article
  • Open Access
11 Citations
4,288 Views
8 Pages

Early Diagnosis in Cerebellar Ataxia, Neuropathy, Vestibular Areflexia Syndrome (CANVAS) by Focusing on Major Clinical Clues: Beyond Ataxia and Vestibular Impairment

  • Laurent Magy,
  • Pauline Chazelas,
  • Laurence Richard,
  • Nathalie Deschamps,
  • Simon Frachet,
  • Jean-Michel Vallat,
  • Corinne Magdelaine,
  • Frédéric Favreau,
  • Flavien Bessaguet and
  • Anne-Sophie Lia
  • + 1 author

CANVAS, a rare disorder responsible for late-onset ataxia of autosomal recessive inheritance, can be misdiagnosed. We investigated a series of eight patients with sensory neuropathy and/or an unexplained cough, who appeared to suffer from CANVAS, and...

  • Systematic Review
  • Open Access
36 Citations
6,358 Views
27 Pages

Trastuzumab is a monoclonal antibody used in the treatment of breast cancer in cases where the tumor overexpresses the HER2 receptor, a cell membrane receptor activated by the epidermal growth factor. Intravenous and subcutaneous administration of tr...

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Biomedicines - ISSN 2227-9059Creative Common CC BY license