Biology, Volume 15, Issue 3

This study sought to evaluate the neuroprotective effects of YGD in an oxidative stress-induced Alzheimer’s disease (AD)-like cellular model and to elucidate the underlying molecular pathways, with a focus on tau phosphorylation, Aβ accumu...

Low-temperature stress significantly limits wheat growth and productivity. Poly-γ-glutamic acid (γ-PGA) is an environmentally friendly green molecular material that plays an important role in plant growth and regulation; however, its prot...

The transient receptor potential vanilloid 4 channel (TRPV4) is thought to play a pivotal role in pulmonary arterial circulation. The present study hypothesizes that TRPV4 activation increases nitric oxide (NO) release and activates calcium-activated...

Fish offer an excellent source of high-quality protein with balanced nutrients and low fat content. However, the increasing global demand for food and the impacts of climate change have led to a significant decline in wild fish stocks. Cultivated fis...

Behavioral regulation in elite combat sports relies on traits such as anxiety, impulsivity, and personality, which are partly shaped by dopaminergic signaling. However, integrative approaches linking multidimensional behavioral profiles with genetic...

Background. Inbred mouse models of autoimmune myocarditis are routinely used to investigate the immune mechanisms underlying dilated cardiomyopathy. However, their translational relevance is limited because observations made in a single inbred strain...

Starvation elicits profound metabolic adaptations in skeletal muscle, enabling survival during nutrient scarcity. While global proteomic changes underpinning muscle atrophy have been studied, the role of lysine β-hydroxybutyrylation (Kbhb), a no...

(1) Background: Testosterone plays a key role in spermatogenesis and in maintaining semen quality and sperm DNA integrity. Consequently, reduced testosterone levels may disrupt these processes and contribute to male infertility. This study aimed to e...

Filamentous opportunistic algae, which behave as opportunistic species, are frequently observed in Eriocheir sinensis aquaculture ponds. These algae can entangle Eriocheir sinensis and release harmful substances during decomposition, thereby negative...

Environmental DNA (eDNA) metabarcoding is an innovative tool that is transforming ecological research. It offers a simple and effective method for simultaneously detecting numerous species across a wide range of environments. The method relies on ass...

Chronic liver injury is accompanied by coordinated disturbances in lipid trafficking and inflammatory–fibrogenic signaling. Transforming growth factor beta 1 (TGF-β1) signaling has been implicated in hepatic fibrogenesis and tumor-associat...

The World Health Organization identifies environmental pollution as a primary global health threat, and its role in the onset and progression of neurological diseases is becoming increasingly clear. In the era of precision medicine, understanding the...

In this study, we conducted molecular identification and complete mitochondrial genome annotation of isopod parasites isolated from mud crabs (Scylla paramamosain) in the China Sea. The specimen was identified as Portunion sinensis, a recently descri...

Heavy metals such as copper are commonly found in aquatic environments. Microalgae can effectively adsorb heavy metals, while high concentrations impair their physiological and biochemical processes. This research investigated the impact of varying c...

Several Fusarium species have demonstrated the ability to thrive in saline soils and to tolerate or prefer high salt concentrations. In this context, the potential halophilic or halotolerant lifestyle of Fusarium pseudograminearum was investigated. F...

Wetlands occupy a mere 6% of Earth’s land surface, yet they contribute 25–45% of global natural methane (CH₄) emissions. A key contradiction emerges here: it is the soil of these wetlands that serves as the host for methane-trophic microo...

Background: Juniperus macrocarpa Sm. is a key shrub species of the Mediterranean coastal dune systems. The species, considered vulnerable, often shows fragmented or declining populations due to coastal erosion and human pressure. However, along...

Glioblastoma (GBM) is the most aggressive and common primary brain tumor, with a median survival of less than a year after diagnosis. γδ T lymphocytes are immune cells that can migrate to tumors and induce malignant cells’ apoptosis...

White matter injury (WMI) and blood–brain barrier (BBB) disruption contribute to neurological and cognitive deficits in intracerebral hemorrhage (ICH), with no effective pharmacological treatments available. Puerarin, with anti-inflammatory, an...

Esterases catalyze the hydrolysis and transesterification of short-chain fatty acid esters, and microbial esterases are used in the production of biofuels, cosmetics, food, and pharmaceuticals. The soil strain Bacillus paralicheniformis T7 secretes e...

Stable isotope analysis is very useful for studying animal nutritional ecology. Feces are the most accessible and non-invasive samples for short-term dietary reconstruction. The giant panda is a special Carnivora species with a highly specialized die...

Until recently, the Karpathos water frog (Pelophylax cerigensis) was considered endemic to Karpathos Island (Greece) and has recently been reclassified by the IUCN as Endangered (EN), having been previously assessed as Critically Endangered (CR). The...

Although light pollution is one of the fastest-growing environmental problems today, we still know little about its impact on specific organisms. Plants are the least understood group in this context. Although environmental observations may suggest s...

Ammonia (NH₃) is an environmental pollutant that enters ecosystems as a result of agricultural activities, industrial accidents, leaks of ammonia-based rocket fuel, and explosions at chemical plants. Temperature changes can alter the toxicity of ammo...

Age-related chronic, low-grade inflammation, known as inflammaging, contributes to tissue damage and disease. In the lungs, inflammaging leads to abnormal tissue remodeling, reduced function, and decreased immunity. A key factor in inflammaging is de...

Long-eared Owls (Asio otus) overwinter in groups, mainly on coniferous trees in human settlements. These owls regurgitate the indigestible parts of their prey as pellets. Analysis of pellet contents provides valuable information on diet composition a...

Understanding how environmental conditions, functional composition, and species richness jointly relate to phylogenetic community structure is important for sustainable forest management under environmental change. Using 2858 plots from the 7th Natio...

Wood vinegar (WV), a by-product of biomass pyrolysis rich in organic acids and phenolic compounds, has gained increasing attention as a sustainable input for crop production, mainly through foliar application. However, its high content of volatile or...

Heart rate variability (HRV) reflects autonomic nervous system (ANS) activity and provides insight into physiological and emotional regulation. Evaluating HRV during postural and emotional challenges may help characterize autonomic adaptability in he...

Recent evidence indicates that both epithelial-to-mesenchymal transition (EMT) and its reverse process, mesenchymal-to-epithelial transition (MET), are key mechanisms driving breast cancer (BC) metastasis. During EMT, epithelial BC cells acquire mese...

This study investigates the genomic basis of immune adaptation in the transparent glass catfish (Kv: Kryptopterus vitreolus), focusing on the loss of the Toll-like receptor 21 (TLR21) gene. Comparative genomic analysis with closely related non-transp...

The XYLP family is reported to be essential for the regulation of growth and development, mediating plant hormone signals, and promoting adaptation to environmental stresses across various plant species. Although the XYLP family in Actinidia chinensi...

Imaging is the gold standard for diagnosing osteoarthritis (OA). However, it remains challenging to precisely assess OA in murine models. The aim of this study is to establish μCT-based geometric indices for assessing the disease severity of post-...

The Amazon Forest harbors one of the largest fungal diversities on the planet, occupying a wide variety of ecological niches comprising terra firme (non-flooded forest), várzea (white-water floodplains), and igapó (black-water floodplai...

The ponyfish genus Nuchequula is presents taxonomic challenges within Leiognathidae due to morphological complexities and a lack of genomic resources. However, the absence of a complete mitochondrial genome for Nuchequula longicornis has hindered com...

Background: Acute lymphoblastic leukemia (ALL) is a hematological malignancy characterised by uncontrolled proliferation of lymphoid cells. Despite improved outcomes with modern chemotherapy, treatment resistance and adverse effects remain major clin...

The mixing of tree species influences soil microbial communities and ecosystem functioning, yet the underlying mechanisms remain inadequately understood. This study aimed to elucidate how different tree species mixtures regulate soil microbial commun...

Weaning is a major stressor for pigs, often increasing agonistic behaviors such as aggression, ear biting, and tail biting, which can impair growth and welfare. This study evaluated the combined effect of rubber sticks and Italian ryegrass hay as env...

Estimating runoff in ungauged catchments remains a major challenge in hydrology, particularly in remote Andean headwaters where limited accessibility and budgetary constraints hinder the long-term operation of monitoring networks. This study integrat...

Infectious diseases present persistent and complex challenges to global public health, with conventional antibiotic therapies increasingly limited by antimicrobial resistance, microbiota disruption, and adverse effects. There is a critical need to ex...

As the lineage-defining transcription factor for regulatory T cells (Tregs), FOXP3 plays a critical role in maintaining immune homeostasis. However, FOXP3 has not been found to regulate the expression of immune suppressive cytokines so far, and the s...

Background: Accumulating evidence demonstrates that inflammatory responses play a critical role in tumor progression, invasion, and metastasis. In recent years, systemic immune-inflammatory (SII) markers have emerged as valuable tools for evaluating...

Urban green spaces increasingly serve as sites of human–tick contact, yet long-term data on tick activity and host associations in urban recreational areas remain limited. This study investigated the seasonal activity patterns of Ixodes ricinus...

The middle–late Cenomanian paleontological area of Algora represents the main concentration of vertebrate remains from the basal Late Cretaceous for southwestern Europe. An unpublished macro-plant assemblage is studied here, being recognized as...

Lung adenocarcinoma is the most common form of lung cancer with a 5-year survival rate of 15%, largely due to asymptomatic metastasis and late diagnosis. Overexpression of Polycomb group (PcG) proteins, particularly EZH2, the catalytic component of P...

Exosomes are nano-sized particles with a structure similar to cells, and they are attracting attention as a premium cosmetic raw material because they can be effectively absorbed through skin pores and delivered without decomposing the active ingredi...

In this commentary, we discuss the concept of field homology, particularly as applied to the brain in comparative neuromorphology. We emphasize its roots in the topological properties of the Bauplan notion (organization plan) as well as in the still...

Collagenases can specifically degrade collagen, showing a wide application prospect in food, leather, waste utilization, biotechnology, and other industries. Currently, Hathewaya histolytica is commonly used in industry to produce collagenases, but i...

(1) Background: Chemotherapy-induced hematological toxicity remains a major limitation to treatment continuity. Docetaxel is widely used in solid tumors due to its clinical efficacy, despite cumulative bone marrow suppression and splenic alterations....

Diseases caused by Bipolaris sorokiniana, expressed as leaf spot blotch (SB) and common root rot (CRR), continue to limit spring wheat production, particularly in dry regions where yield losses may reach 35–40%. This study evaluated resistance...