Biology, Volume 14, Issue 10
2025 October - 155 articles
Cover Story: This review explores how high-fat and ketogenic diets influence brain metabolism and contribute to neurodegenerative processes. Prolonged exposure to such diets alters glucose utilization, enhances oxidative stress, and triggers neuroinflammation in regions including the hippocampus, hypothalamus, and dopaminergic pathways. These biochemical disturbances may impair cognition and accelerate mechanisms underlying Alzheimer’s, Parkinson’s, and other neurodegenerative diseases. Despite certain neuroprotective effects of ketogenic diets, long-term safety and the balance between beneficial and harmful fat types remain uncertain, underscoring the need for further translational research. View this paper - Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
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