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Biology, Volume 14, Issue 10

2025 October - 155 articles

Cover Story: This review explores how high-fat and ketogenic diets influence brain metabolism and contribute to neurodegenerative processes. Prolonged exposure to such diets alters glucose utilization, enhances oxidative stress, and triggers neuroinflammation in regions including the hippocampus, hypothalamus, and dopaminergic pathways. These biochemical disturbances may impair cognition and accelerate mechanisms underlying Alzheimer’s, Parkinson’s, and other neurodegenerative diseases. Despite certain neuroprotective effects of ketogenic diets, long-term safety and the balance between beneficial and harmful fat types remain uncertain, underscoring the need for further translational research. View this paper
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Articles (155)

  • Article
  • Open Access
1 Citations
975 Views
22 Pages

Comprehensive Analysis of the ARF Gene Family Reveals Their Roles in Chinese Chestnut (Castanea mollissima) Seed Kernel Development

  • Xili Liu,
  • Yun Li,
  • Manman Liang,
  • Dongsheng Wang,
  • Meng Wang,
  • Yi Lu,
  • Xia Liu,
  • Haie Zhang,
  • Xiangyu Wang and
  • Liyang Yu

21 October 2025

Auxin response factors (ARFs) are a class of significant transcription factors that play crucial roles in the regulation of plant growth and development. Although ARF genes have been extensively characterized in various plants, their functions in per...

  • Article
  • Open Access
673 Views
19 Pages

21 October 2025

PIWI-interacting RNAs (piRNAs) are small non-coding RNAs that interact with PIWI proteins and play essential roles in genome stability, gonadal development, and gametogenesis in animals. The Japanese flounder (Paralichthys olivaceus) is an important...

  • Article
  • Open Access
806 Views
20 Pages

21 October 2025

RNA editing is a crucial mechanism regulating gene expression in plant organellar genomes, which optimizes protein structures through base substitution and plays a vital role in plant growth, development, and stress adaptation. This study revises the...

  • Article
  • Open Access
1,245 Views
16 Pages

Research on the Mechanism of Hypoxia Tolerance of a Hybrid Fish Using Transcriptomics and Metabolomics

  • Yuhua Tang,
  • Jiayi Yang,
  • Chunchun Zhu,
  • Hong Zhang,
  • Li Hu,
  • Wenting Rao,
  • Xinxin Yu,
  • Ming Wen,
  • Min Tao and
  • Shaojun Liu

21 October 2025

The novel hybrid fish BTB, derived from crossing blunt snout bream (Megalobrama amblycephala, BSB) and topmouth culter (Culter alburnus, TC), exhibits markedly hypoxia tolerance in aquaculture. In this study, hypoxic treatment experiments confirmed t...

  • Article
  • Open Access
890 Views
19 Pages

CGF-Conditioned Medium Modulates Astrocytic Differentiation and Invasiveness in U87MG Glioblastoma Cells

  • Laura Giannotti,
  • Benedetta Di Chiara Stanca,
  • Francesco Spedicato,
  • Christian Demitri,
  • Eleonora Stanca,
  • Andrea Palermo,
  • Franco Ferrante,
  • Fabrizio Damiano,
  • Maria Antonietta De Sangro and
  • Luisa Siculella
  • + 1 author

21 October 2025

Background: Glioblastoma (GBM) is a highly aggressive tumor characterized by elevated plasticity and poor differentiation. Platelet-derived preparations such as Concentrated Growth Factors (CGF) are rich in bioactive molecules, but their effects on t...

  • Article
  • Open Access
1 Citations
844 Views
21 Pages

21 October 2025

Saline aquaculture tailwater challenges conventional constructed wetlands (CWs) with their limited phosphorus (P) removal capacity. To address this, iron-carbon constructed wetlands (IC-CWs) were developed and operated under four salinity gradients (...

  • Review
  • Open Access
2 Citations
1,005 Views
18 Pages

21 October 2025

Plasmodium parasites are the causative agents of malaria and can infect humans and other vertebrates, impacting socioeconomic development and causing significant health issues globally. Plasmodium falciparum causes the most severe type of infection,...

  • Article
  • Open Access
864 Views
15 Pages

Characterization of Ingested Microplastics in a Regional Endemic Lizard Apathya cappadocica (Werner, 1902) from Türkiye

  • Cantekin Dursun,
  • Nagihan Demirci,
  • Kamil Candan,
  • Ahmet Gökay Korkmaz,
  • Ecem Büşra Hastürk,
  • Elif Yıldırım Caynak,
  • Çetin Ilgaz,
  • Yusuf Kumlutaş and
  • Serkan Gül

21 October 2025

This study investigated the presence, characteristics, and distribution of ingested microplastics (MPs) in Apathya cappadocica, a regional endemic lizard species. A total of 93 individuals were examined, and MPs were found in 19.35% (n = 18) of them....

  • Article
  • Open Access
617 Views
15 Pages

21 October 2025

The impact of substrates with different physicochemical properties on the response of rhizosphere fungi in rice to salt stress has not been fully explored. The purpose of this study is to reveal the adaptation characteristics of fungal colonies to sa...

  • Article
  • Open Access
1,706 Views
15 Pages

Efficient Serum-Free Rabies Virus Propagation Using BSR and Vero Cell Lines: A Comparative Evaluation of BioNOC II® Macrocarriers in the BelloStage™-3000 Bioreactor Versus Conventional Microcarriers

  • Zhanat Amanova,
  • Zhanna Sametova,
  • Sholpan Turyskeldy,
  • Alina Kurmasheva,
  • Ruslan Abitayev,
  • Abdurakhman Ussembay,
  • Zhanat Kondibaeva,
  • Dariya Toktyrova,
  • Dana Mazbayeva and
  • Yerbol Bulatov
  • + 2 authors

21 October 2025

The rabies virus remains a significant public health threat, particularly in regions with limited access to vaccination. This study shows that the BelloStage™-3000 bioreactor, operating on the “Tide Motion” principle, in combination...

  • Article
  • Open Access
676 Views
12 Pages

Possible Involvement of Leptin in Pathogenesis of Periodontal Disease

  • Małgorzata Kozak,
  • Agata Poniewierska-Baran,
  • Michał Czerewaty,
  • Karolina Łuczkowska,
  • Małgorzata Mazurek-Mochol,
  • Bogusław Machaliński and
  • Andrzej Pawlik

20 October 2025

Periodontitis is a chronic inflammatory condition of the periodontal tissues, ultimately leading to their destruction. The periodontal ligament is a key structure that not only secures the teeth within the alveolus but can also act as a source of num...

  • Review
  • Open Access
2 Citations
6,450 Views
27 Pages

AI and Machine Learning in Biology: From Genes to Proteins

  • Zaw Myo Hein,
  • Dhanyashri Guruparan,
  • Blaire Okunsai,
  • Che Mohd Nasril Che Mohd Nassir,
  • Muhammad Danial Che Ramli and
  • Suresh Kumar

20 October 2025

Artificial intelligence (AI) and machine learning (ML), especially deep learning, have profoundly transformed biology by enabling precise interpretation of complex genomic and proteomic data. This review presents a comprehensive overview of cutting-e...

  • Review
  • Open Access
4 Citations
1,290 Views
15 Pages

20 October 2025

Insecticide resistance has become a critical issue threatening global agricultural production and food security. Previous studies have primarily focused on resistance mechanisms such as target-site mutations, enhanced metabolic detoxification, and re...

  • Article
  • Open Access
823 Views
14 Pages

20 October 2025

The double-sex and mab-3-related transcription factors (Dmrt) are widely distributed in the animal kingdom and play a crucial role in sex determination and differentiation. In this study, we identified eight Dmrt transcription factors in the genome o...

  • Article
  • Open Access
819 Views
21 Pages

Impacts of Harvesting Activities on the Structure of the Intertidal Macrobenthic Community on Lvhua Island, China

  • Shuhan Wang,
  • Yuqing Wang,
  • Jiaming Ou,
  • Jianing Sun,
  • Kaiyi Wang,
  • Qiao Zou,
  • Jianqu Chen,
  • Li Li,
  • Kai Wang and
  • Shouyu Zhang

20 October 2025

Human harvesting exerts significant pressure on intertidal ecosystems, yet its impact on community structure remains insufficiently understood. To assess these effects, we investigated macrobenthic communities on Lvhua Island and adjacent islets by i...

  • Article
  • Open Access
698 Views
11 Pages

Warning Before a Fight: The Role of Distance and Ritualized Agonistic Behaviors in Minimizing Aggression in the Jamaican Fruit Bat

  • Orlando R. Vivanco-Montané,
  • Jorge E. Morales-Mávil,
  • Laura T. Hernández-Salazar,
  • Jairo Pérez-Torres and
  • Edgar Ahmed Bello-Sánchez

20 October 2025

In many vertebrates, ritualized behaviors serve to settle conflicts while minimizing the risk of injury. The Jamaican fruit bat (Artibeus jamaicensis) is a polygynous species that roosts in caves, where dominant males form and defend harems by displa...

  • Article
  • Open Access
690 Views
24 Pages

Analysis of the Transcriptome Response to Low Nitrogen in Populus ussuriensis

  • He Feng,
  • Yue Chang,
  • Runze Liu,
  • Wenlong Li,
  • Zhiwei Liu,
  • Ming Wei,
  • Zhibin Luo and
  • Chenghao Li

20 October 2025

(1) Background: Nitrogen is a key element that is essential for plant growth, and it is absorbed by roots from the soil. Nitrogen stress severely limits forest tree productivity; therefore, elucidating the molecular mechanisms underlying nitrogen str...

  • Article
  • Open Access
1 Citations
1,098 Views
22 Pages

Genome-Wide Association Study Revealed Candidate Genes Associated with Litter Size, Weight, and Body Size Traits in Tianmu Polytocous Sheep (Ovis aries)

  • Wenna Liu,
  • Shengchao Ma,
  • Qingwei Lu,
  • Sen Tang,
  • Nuramina Mamat,
  • Yaqian Wang,
  • Wei Hong,
  • Xiangrong Hu,
  • Cuiling Wu and
  • Xuefeng Fu

20 October 2025

Reproductive and growth traits are key economic traits in sheep. This study aims to identify key single nucleotide polymorphisms (SNPs) and candidate genes associated with reproductive and growth traits in Tianmu polytocous sheep through a genome-wid...

  • Article
  • Open Access
588 Views
13 Pages

20 October 2025

Digitalis purpurea, valued for its cardiotonic glycosides, remains an important medicinal species. Optimizing cultivation to enhance photosynthetic efficiency is critical for improving both biomass accumulation and metabolite yield. In this study, we...

  • Article
  • Open Access
723 Views
15 Pages

20 October 2025

Benthic macroinvertebrates are widely used for river ecosystem health monitoring, yet challenges remain in non-wadable rivers, particularly regarding sampling effort. We evaluated hand-net sampling efficiency at three sites along the Danjiang River (...

  • Article
  • Open Access
3 Citations
1,457 Views
19 Pages

Carvacrol as a Therapeutic Candidate in Breast Cancer: Insights into Subtype-Specific Cellular Modulation

  • Asmaa Abuaisha,
  • Emir Nekay,
  • Ozgur Yilmaz,
  • Baris Yildiz,
  • Tarik Mecit,
  • Cuneyd Yavas,
  • Berrin Papila,
  • Halil Ibrahim Arslan,
  • Aybuke Hilal Gumus and
  • Selman Emiroglu
  • + 2 authors

19 October 2025

Background: Carvacrol, a natural phenolic monoterpenoid, has been suggested to exert anticancer effects; however, its underlying mechanisms in breast cancer (BC) remain incompletely defined. Methods: MCF-7 (HR+) and MDA-MB-231 (TNBC) BC cell lines we...

  • Article
  • Open Access
1,026 Views
21 Pages

18 October 2025

Chemosensory systems are essential in insect behavior, with several key genes associated with these systems emerging as potential targets for pest control. Porphyrophora sophorae (Archangelskaya, 1935), a destructive pest of Chinese licorice (Glycyrr...

  • Article
  • Open Access
1,034 Views
16 Pages

18 October 2025

Biochar can act as a carrier and a soil carbon source for rapid colonization by plant growth-promoting rhizobacteria (PGPR). However, the effects of a combined application of biochar and PGPR on soil physicochemical properties, humus components, and...

  • Article
  • Open Access
806 Views
20 Pages

PIWIs Regulate Spermatogonia Self-Renewal and Differentiation by Wnt/β-Catenin Signaling Pathway in Eriocheir sinensis

  • Bang-Hong Wei,
  • Zhan Zhao,
  • Hong-Yu Qi,
  • Zhen-Fang Li,
  • Wan-Xi Yang and
  • Shuang-Li Hao

18 October 2025

The roles of PIWI in mammalian spermatogenesis have been well-studied but are largely unknown in invertebrates such as the Chinese mitten crab (Eriocheir sinensis), which produces non-flagellar sperm. Here, we demonstrate that knockdown of PIWIs sign...

  • Review
  • Open Access
2 Citations
1,259 Views
17 Pages

18 October 2025

Humans form deep attachments to some nonhuman animals, yet these attachments are unequally distributed across the tree of life. Drawing on evolutionary biology, comparative cognition, neuroscience, and cultural anthropology, this narrative review exp...

  • Review
  • Open Access
1 Citations
3,040 Views
29 Pages

Human Blastoid: A Next-Generation Model for Reproductive Medicine?

  • Anfisa S. Ryabchenko,
  • Vepa K. Abdyev,
  • Ekaterina A. Vorotelyak and
  • Andrey V. Vasiliev

18 October 2025

Human early embryogenesis remains unexplored due to limited access to human embryos for research purposes. Meanwhile, the number of natural early pregnancy terminations remains significant, and solving the problem requires a deep understanding of the...

  • Article
  • Open Access
1,044 Views
13 Pages

17 October 2025

Single-cell RNA sequencing (scRNA-seq) has revolutionized genomic investigations by enabling the exploration of gene expression heterogeneity at the individual cell level. However, the complexity of scRNA-seq data analysis remains a challenge for man...

  • Article
  • Open Access
708 Views
15 Pages

Isolation and Identification of Antifungal Polyketones from Bacillus velezensis DJ1 and Their Biocontrol Potential Against Corn Stalk Rot

  • Meng Sun,
  • Wanjia Du,
  • Jialing Zhang,
  • Yan Xu,
  • Zixuan Wang,
  • Lu Zhou,
  • Gengxuan Yan and
  • Shumei Zhang

17 October 2025

Corn stalk rot, caused by Fusarium graminearum, severely threatens corn production, while chemical fungicides lead to resistance and environmental risks. Thus, exploring environmentally friendly biocontrol agents is crucial. Though Bacillus polyketon...

  • Article
  • Open Access
2 Citations
808 Views
13 Pages

Evidence of Folliculogenesis and the Potential of Oocyte Recovery from Koalas with Different Levels of Reproductive Pathology

  • Stephen D. Johnston,
  • Jackson Boyd,
  • Patricio D. Palacios,
  • Julien Grosmaire,
  • Alexander Lee,
  • Lyndal Hulse,
  • Leslie Vega,
  • Michael Pyne,
  • Andres Gambini and
  • Chiara Palmieri

17 October 2025

Each year, hundreds of female koalas are presented to koala hospitals suffering from a range of morbidities, many of which require euthanasia for animal welfare reasons. These koalas represent a possible resource for genetic recovery by means of oocy...

  • Review
  • Open Access
3,035 Views
32 Pages

The Brown Bear and Hibernating Mammals as a Translational Model for Human Resilience: Insights for Space Medicine, Critical Care, and Austere Environments

  • Jainam Shah,
  • Ryung Lee,
  • Sachin Pathuri,
  • Jason Zheng,
  • Joshua Ong,
  • Alex Suh,
  • Kimia Rezaei,
  • Gagandeep Mudhar,
  • Andrew D. Parsons and
  • Andrew G. Lee
  • + 1 author

17 October 2025

Long-term spaceflight induces multisystem stress, including cardiovascular deconditioning, skeletal muscle atrophy, immune suppression, and neuro-ocular syndromes. Current countermeasures reduce symptoms but cannot replicate the synergistic resilienc...

  • Article
  • Open Access
658 Views
19 Pages

Co-Degradation of Coal and Sawdust for Enhanced Microbial Methane Production

  • Liu Zhu,
  • Wangjie Diao,
  • Zeguang Tang,
  • Yi Liu and
  • Yanxin Gu

17 October 2025

Microbial coal gasification is a highly promising bioenergy technology, yet its efficiency is often constrained by the highly polymeric structure of coal. This study explores a novel approach to enhance methane production from low-rank coal through a...

  • Article
  • Open Access
1,299 Views
26 Pages

From Genome-Wide SNPs to Neuroimmune Crosstalk: Mapping the Genetic Landscape of IBD and Its Brain Overlap

  • Utkarsh Tripathi,
  • Yam Stern,
  • Inbal Dagan,
  • Ritu Nayak,
  • Eva Romanovsky,
  • Eran Zittan and
  • Shani Stern

17 October 2025

Inflammatory bowel disease (IBD), comprising Crohn’s disease (CD) and ulcerative colitis (UC), arises from complex genetic and environmental interactions. Here, we integrate genome-wide association study (GWAS) meta-analyses with tissue-specifi...

  • Article
  • Open Access
1,029 Views
21 Pages

Development and Validation of a 7-eRNA Prognostic Signature for Lung Adenocarcinoma

  • Yiwen Sun,
  • Keng Chen,
  • Jingkai Zhang,
  • Zhijie Hu,
  • Mingmei Xiong,
  • Zhigang Fang,
  • Guanmei Chen,
  • Xiaomei Meng,
  • Baolin Liao and
  • Luping Lin
  • + 1 author

17 October 2025

Enhancer RNAs (eRNAs) are abundant in most human cells and tissues, and quantifying eRNAs has become a robust approach for biomarker discovery. While eRNAs play crucial roles in regulating biological processes and cancer progression, their functions...

  • Review
  • Open Access
1,914 Views
20 Pages

17 October 2025

Adamantane is a unique tricyclic hydrocarbon with a rigid, diamond-like structure. It is widely distributed in natural hydrocarbons and has significant potential applications in medicine, materials science, and pharmaceuticals. Despite its high chemi...

  • Review
  • Open Access
1 Citations
1,014 Views
17 Pages

Remodeling of Germ Cell mRNPs for Translational Control

  • Brett D. Keiper and
  • Hayden P. Huggins

17 October 2025

The localization and remodeling of mRNPs is inextricably linked to translational control. In recent years there has been great progress in the field of mRNA translational control due to the characterization of the proteins and small RNAs that compose...

  • Article
  • Open Access
1 Citations
1,353 Views
16 Pages

Unique and Under Pressure: Conservation Genetics of an Isolated Alpine Salamander Population

  • Stephan Koblmüller,
  • Sylvia Schäffer,
  • Raphael Donabaum,
  • Irmgard Sedlmayr,
  • Werner Kammel,
  • Eva Bernhart and
  • Lukas Zangl

17 October 2025

The Alpine salamander (Salamandra atra) is a cold-adapted amphibian with low dispersal capacity, endemic to the Alps and Dinarides. Isolated populations at the range’s margins are especially vulnerable to habitat fragmentation and genetic erosion. We...

  • Article
  • Open Access
1 Citations
941 Views
25 Pages

Cockle Population Dynamics in a Complex Ecological Aquatic System

  • Simão Correia,
  • Marta Lobão Lopes,
  • Ana Picado,
  • João M. Dias,
  • Nuno Vaz,
  • Rosa Freitas and
  • Luísa Magalhães

17 October 2025

Cerastoderma edule, the European edible cockle, is a key species in the coastal ecosystems of Portugal, particularly in Ria de Aveiro, a biodiversity hotspot and a critical area for cockle harvesting. This study aimed to assess the population dynamic...

  • Article
  • Open Access
633 Views
24 Pages

16 October 2025

Global climate change is accelerating and human pressures are intensifying, exerting profound impacts on biodiversity and ecosystem service functions. The accurate prediction of species distributions has thus become a critical research direction in e...

  • Article
  • Open Access
1,039 Views
25 Pages

16 October 2025

Accurate diagnosis of myocardial infarction (MI) holds significant clinical importance for public health systems. Deep learning-based ECG, classification and localization methods can automatically extract features, thereby overcoming the dependence o...

  • Article
  • Open Access
672 Views
20 Pages

Microsatellite Markers Developed Based on Transcriptomic Data Reveal the Genetic Diversity and Population Genetic Structure of Angulyagra polyzonata in Guangxi, China

  • Shengjie Zhang,
  • Dapeng Wang,
  • Kangqi Zhou,
  • Yong Lin,
  • Zhong Chen,
  • Junqi Qin,
  • Xuesong Du,
  • Liuping Long,
  • Caiqun Zhang and
  • Wenhong Li
  • + 1 author

16 October 2025

Angulyagra polyzonata is a significant freshwater snail species in southern China. However, its wild resources have sharply declined due to overfishing. To assess the current status of germplasm resources in the Guangxi region, during this study, we...

  • Article
  • Open Access
794 Views
13 Pages

16 October 2025

The genus Skrjabinoplagiorchis is monotypic, with Skrjabinoplagiorchis polonicus parasitizing rodents in the Western Palaearctic. This genus is classified within the family Plagiorchiidae; however, its taxonomic position remains unclear. In the prese...

  • Review
  • Open Access
1 Citations
1,119 Views
15 Pages

Aldose Reductase Involvement in EMT: Emerging Insights and Current Proposed Molecular Mechanisms

  • Gemma Sardelli,
  • Francesca Felice,
  • Rossella Mosca,
  • Martina Avanatti and
  • Roberta Moschini

16 October 2025

Aldose reductase (AKR1B1) is a member of the aldo-keto reductase (AKR) family and plays a variety of roles in many metabolic and physiological processes. Although its function in the polyol pathway and defense against reactive carbonyl species is wel...

  • Review
  • Open Access
2,114 Views
13 Pages

Insights into the Anti-Inflammatory Effects of Soft Tissue Manipulation

  • Jonathan W. Lowery,
  • Basil Mustaklem,
  • Connor Wakefield,
  • Hailey Brown,
  • Madeline M. Sasse,
  • Samuel Baule,
  • Sierra Street,
  • Liza Pradhan,
  • Simran Sandhu and
  • Tien-Min Gabriel Chu
  • + 3 authors

15 October 2025

Soft tissue manipulation (STM) is widely used by physical therapists, massage therapists, athletic trainers, and osteopathic physicians to manage musculoskeletal pain, yet its biological mechanisms remain poorly understood. Preclinical studies indica...

  • Article
  • Open Access
967 Views
26 Pages

15 October 2025

Macroalgal–coral interactions (MCI) are an integral yet understudied component of coral reef ecology, particularly in healthy systems where they may represent stable coexistence rather than competition. This study provides the first comprehensi...

  • Article
  • Open Access
2 Citations
737 Views
22 Pages

Fruits and Seeds as Indicators of the Genetic Diversity of Hymenaea martiana (Fabaceae) in Northeast Brazil

  • Joyce Naiara da Silva,
  • Guilherme Vinícius Gonçalves de Pádua,
  • Caroline Marques Rodrigues,
  • João Henrique Constantino Sales Silva,
  • Cosma Layssa Santos Gomes,
  • Marília Hortência Batista Silva Rodrigues,
  • Maria Karoline Ferreira Bernardo,
  • Eduardo Luã Fernandes da Silva,
  • Luís Gustavo Alves de Almeida and
  • Edna Ursulino Alves
  • + 3 authors

15 October 2025

Hymenaea martiana is a species native to Brazil. It has ecological value, contributes to forest restoration, and is economically important because of the use of its wood and fruits. However, it is frequently exploited. Therefore, understanding geneti...

  • Article
  • Open Access
772 Views
21 Pages

15 October 2025

Fluctuating water temperatures and bacterial pathogens such as Edwardsiella tarda pose a serious threat to mariculture, resulting in significant economic losses within the flounder industry. A previous study revealed that elevated temperature enhance...

  • Article
  • Open Access
680 Views
17 Pages

Methodological Pitfalls of Monitoring: Water Conditions Affect the Efficiency of Bottle Traps and Capture Success

  • Teodor J. Purger,
  • Boldizsár Szűcs,
  • József Dezső,
  • László Wágner,
  • Dragica Purger and
  • Jenő J. Purger

15 October 2025

Wetland diversity and associated wildlife is declining globally. The Szaporca Old-Drava oxbow, one of Hungary’s first wetlands designated under the Ramsar Convention, has been threatened by desiccation, prompting the implementation of water rep...

  • Article
  • Open Access
974 Views
18 Pages

14 October 2025

Temperature has always been an important environmental factor, and changes in water temperature are closely related to the entire life process of fish. Investigating the impact of thermal stress on fish physiology is critical for optimizing aquacultu...

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Biology - ISSN 2079-7737