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Biology, Volume 14, Issue 11

2025 November - 168 articles

Cover Story: Glioblastoma (GB) is an extremely aggressive tumor for which effective therapy is still in its infancy. A major challenge in advancing treatment is the availability of reliable models that capture the complexity of the disease for preclinical testing of new candidate drugs. This review provides a comprehensive overview of current GB models, highlighting cutting-edge technologies and their multimodal integration in GB-on-chip systems, as well as in silico and in vivo approaches. We critically examine each model’s origins, objectives, strengths, weaknesses and clinical relevance, from an original perspective. Finally, we propose a practical roadmap to enhance the reliability and translational impact of GB preclinical research. View this paper
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Articles (168)

  • Article
  • Open Access
1 Citations
1,257 Views
10 Pages

Creating New Forms of Hexaploid Triticale Associating Complete R and D Genomes

  • Michel Bernard,
  • Sylvie Bernard,
  • Ekaterina Badaeva and
  • Rolf Schlegel

20 November 2025

Triticale, a man-made cereal, has been grown worldwide since the 1980s in order to replace established cereals in difficult areas, at least partially. The present cultivars are mostly hexaploid genotypes with 42 chromosomes, of genomic structure AA B...

(This article belongs to the Section Biotechnology)
  • Review
  • Open Access
10 Citations
5,311 Views
28 Pages

Chagas Disease in the 21st Century: Global Spread, Ecological Shifts, and Research Frontiers

  • Marina da Silva Ferreira,
  • Rosa Amelia Maldonado and
  • Priscila Silva Grijó Farani

20 November 2025

Chagas disease (CD), caused by the parasite Trypanosoma cruzi, remains one of the most important neglected tropical diseases. Historically confined to rural areas of Latin America, the disease has now become a global health challenge due to increased...

(This article belongs to the Special Issue Advances in Leishmaniasis and Chagas Disease: Biology, Epidemiology, Treatment and Control (2nd Edition))
  • Correction
  • Open Access
1 Citations
626 Views
4 Pages

Correction: Lu et al. Autophagy Alters Bladder Angiogenesis and Improves Bladder Hyperactivity in the Pathogenesis of Ketamine-Induced Cystitis in a Rat Model. Biology 2021, 10, 488

  • Jian-He Lu,
  • Yi-Hsuan Wu,
  • Tai-Jui Juan,
  • Hung-Yu Lin and ,
  • Rong-Jyh Lin,
  • Kuang-Shun Chueh,
  • Yi-Chen Lee,
  • Chao-Yuan Chang and
  • Yung-Shun Juan
  • + 4 authors+ 0 author

20 November 2025

In the original publication [...]

(This article belongs to the Special Issue Molecular Diagnosis of Pathologies of the Lower Urinary Tract)
  • Article
  • Open Access
2 Citations
1,235 Views
15 Pages

20 November 2025

Datura stramonium, which is originally native to Mexico, has been recognized as an invasive species following its introduction to China, where it has proliferated extensively. Despite its widespread impact, the mechanisms driving the invasion of D. s...

  • Article
  • Open Access
2 Citations
1,147 Views
15 Pages

Photosynthesis and Spatial Distribution of Surface Phytoplankton in the Yangtze Estuary and Adjacent Waters During Spring

  • Haojie Hu,
  • Jing Xia,
  • Xiu Gao,
  • Wenlian Huang and ,
  • Jiuyi Pan,
  • Zhi Chen and
  • Ji Li
  • + 2 authors+ 0 author

20 November 2025

Chlorophyll fluorescence provides direct insights into the physiological status of algae, contributing to the understanding of the marine carbon cycle. However, in situ measurements of phytoplankton photosynthetic physiology remain relatively scarce...

(This article belongs to the Special Issue Biology, Ecology and Management of Aquatic Macrophytes and Algae—2nd Edition)
  • Article
  • Open Access
1 Citations
849 Views
17 Pages

Synthesis of Iron Nanoparticles from Spartina alterniflora for Cadmium Immobilization in Coastal Wetland Sediments

  • Jian Li,
  • Xuejing Zang,
  • Zhanrui Leng,
  • Yan Li and ,
  • Shiyan Xu and
  • Na Wei
  • + 1 author+ 0 author

19 November 2025

A green synthesis method for iron nanoparticles was developed using the leaf extract of the invasive plant Spartina alterniflora (Sa-FeNPs), targeting the remediation of cadmium (Cd) in coastal sediments. The obtained Sa-FeNPs, characterized as amorp...

(This article belongs to the Special Issue Metals in Biology (2nd Edition))
  • Article
  • Open Access
1 Citations
1,225 Views
15 Pages

Taurine-Dominated Feeding Attractant Mixture Induces Efficient Foraging in Neptunea cumingii

  • Deliang Li,
  • Wenjing Ren,
  • Pengcheng Sun,
  • Zhaoyu He and ,
  • Fenghe An,
  • Lei Gao,
  • Xueshu Zhang and
  • Ming Li
  • + 3 authors+ 0 author

19 November 2025

The Neptunea cumingii (N. cumingii) fishing industry has long relied on expensive and perishable skate (Raja porosa) meat as bait. The unknown chemical attraction mechanism has hindered the development of artificial alternatives. This study employed...

  • Article
  • Open Access
3 Citations
1,173 Views
22 Pages

Spatiotemporal Dynamics of Ecological Vulnerability to Climate Change in Northwestern Sichuan’s Terrestrial Ecosystems of China: Conservation Implications

  • Cuicui Jiao,
  • Xiaobo Yi,
  • Ji Luo,
  • Ying Wang and ,
  • Yuanjie Deng,
  • Jiangtao Gou and
  • Danting Luo
  • + 2 authors+ 0 author

19 November 2025

Climate change intensifies ecosystem vulnerability in mountainous regions, particularly in Northwestern Sichuan’s Terrestrial Ecosystems (TENS), where complex terrain amplifies impacts on biodiversity and carbon dynamics. This study assesses sp...

(This article belongs to the Special Issue Impacts of Climate Change on Terrestrial Carbon Cycling and Biodiversity Across Spatial and Temporal Scales)
  • Article
  • Open Access
1 Citations
1,511 Views
19 Pages

19 November 2025

Antibiotic resistance genes (ARGs) and microbial communities in pig and cow dung from rural China were systematically profiled using high-throughput quantitative PCR arrays and 16S rDNA amplicon sequencing to assess their environmental dissemination...

  • Article
  • Open Access
4 Citations
1,296 Views
22 Pages

19 November 2025

Soil degradation from long-term chemical fertilization poses serious challenges to the sustainability of black soil agroecosystems in Northeast China, particularly for the cultivation of medicinal plants such as Aralia continentalis Kitag. To evaluat...

  • Article
  • Open Access
1 Citations
1,484 Views
17 Pages

A Deep Autoencoder Compression-Based Genomic Prediction Method for Whole-Genome Sequencing Data

  • Hailiang Song,
  • Tian Dong,
  • Wei Wang,
  • Xiaoyu Yan and ,
  • Chenfan Geng,
  • Song Bai and
  • Hongxia Hu
  • + 2 authors+ 0 author

19 November 2025

Genomic prediction using whole-genome sequencing (WGS) data is challenged by the imbalance between a limited sample size (n) and an extensive number of single-nucleotide polymorphisms (SNPs) (p), where n ≪p. The high dimensionality of WGS...

(This article belongs to the Special Issue Methods in Bioinformatics and Computational Biology)
  • Article
  • Open Access
5 Citations
1,926 Views
10 Pages

Non-Linear Association Between Phase Angle and Body Fat in a Sample of US Adults

  • Federica Frau,
  • Eduardo Pizzo Junior,
  • Stefano Cabras,
  • Myosotis Massidda and
  • Elisabetta Marini

19 November 2025

Phase angle (PhA) is a widely used bioimpedance index associated with cell mass, membrane integrity, skeletal muscle mass and quality, and body fluid distribution. This study aims to investigate the relationship between PhA and body fat, which is poo...

  • Article
  • Open Access
2 Citations
1,158 Views
16 Pages

Study on the Genomic Basis of Adaptation in Salsk Sheep

  • Olga Lukonina,
  • Siroj Bakoev,
  • Yury Kolosov,
  • Vagif Akhmedli and ,
  • Ilona Bakoeva,
  • Maria Kolosova,
  • Alexandr Usatov,
  • Anatoliy Kolosov and
  • Lyubov Getmantseva
  • + 4 authors+ 0 author

18 November 2025

This study investigates the genetic architecture of Salsk sheep—a long-established Russian Merino-type breed from the southern steppes—highlighting their broad genetic diversity, resilience to cold and drought, and dual-purpose (wool and...

  • Article
  • Open Access
2 Citations
1,090 Views
11 Pages

Three Different Biopesticides Against Megalurothrips usitatus (Thysanoptera: Thripidae) and Their Toxicological and Biochemical Impacts

  • Zuying Fu,
  • Ziyu Cao,
  • Changyu Xiong,
  • Yifan Cui and ,
  • Yuanrun Cheng,
  • Ying Wang,
  • Rong Zhang,
  • Chang Liu,
  • Wei Sun and
  • Shuhua Wei
  • + 7 authors+ 2 authors

18 November 2025

The laboratory toxicity and physiological effects of three biopesticides—the entomopathogenic fungus Beauveria bassiana, the biocontrol bacterium Bacillus safensis, and the botanical insecticide Artemisia ordosica essential oil—were evalu...

  • Article
  • Open Access
2 Citations
849 Views
15 Pages

18 November 2025

Organic anion transporting polypeptide 1B1 (OATP1B1) is specifically expressed at the basolateral membrane of human liver cells and transports a wide range of endogenous compounds, toxins, and drugs, making it a crucial factor in determining the phar...

(This article belongs to the Section Biochemistry and Molecular Biology)
  • Article
  • Open Access
2 Citations
1,708 Views
20 Pages

Lipidomic and Transcriptomic Reveals Variations in Lipid Deposition During Goose Fatty Liver Formation

  • Qi Zhang,
  • Chuning Bai,
  • Mingai Zhang,
  • Bin Yue and ,
  • Jing Zhang,
  • Min Kong,
  • Binghan Wang,
  • Baowei Wang and
  • Wenlei Fan
  • + 4 authors+ 0 author

18 November 2025

Goose foie gras production requires force-feeding with high-energy feed, disrupting hepatic lipid homeostasis and causing excessive lipid accumulation. To investigate the formation mechanism, we collected liver samples from Landes geese at pre-force-...

(This article belongs to the Section Biochemistry and Molecular Biology)
  • Communication
  • Open Access
2 Citations
1,396 Views
11 Pages

18 November 2025

Botrytis cinerea, a necrotrophic fungal pathogen responsible for gray mold, poses a severe threat to over 1400 plant species, causing significant pre- and postharvest losses worldwide. RNA interference (RNAi)-based strategies, particularly spray-indu...

(This article belongs to the Special Issue Advances in Research on Diseases of Plants (2nd Edition))
  • Article
  • Open Access
1,231 Views
21 Pages

HSBDF-Derived Bioactive Components Broadly Inhibit Enteroviruses by Targeting 3C Protease and Attenuating Inflammatory Responses

  • Ruolan Hu,
  • Lin Guan,
  • Siyue Li,
  • Chunlin Liu and ,
  • Gang Huang,
  • Fuxing Lou,
  • Hongzheng Jiang,
  • Shuqi Wang,
  • Zehan Pang and
  • Bixia Hong
  • + 10 authors+ 5 authors

18 November 2025

Human enteroviruses are important pathogens of hand-foot-and-mouth disease, poliomyelitis, and encephalitis, etc., posing substantial global health burdens with no specific approved therapeutics. While traditional Chinese medicine (TCM) has demonstra...

(This article belongs to the Section Infection Biology)
  • Article
  • Open Access
4 Citations
1,422 Views
20 Pages

18 November 2025

Lycium ruthenicum Murr. is a highly nutritional cash crop due to its fruit-abundant anthocyanins. With the development of the fruit, the color changes from green to dark purple and the anthocyanin content gradually increases. But the molecular mechan...

  • Article
  • Open Access
1 Citations
1,034 Views
14 Pages

Comparative Analysis of Muscle Metabolome and Amino Acid Profiles in All-Female Rainbow Trout (Oncorhynchus mykiss) from Different Germplasm Sources

  • Tianqing Huang,
  • Baorui Cao,
  • Yunchao Sun,
  • Enhui Liu and ,
  • Wei Gu,
  • Kaibo Ge,
  • Gaochao Wang,
  • Junran Tan,
  • Guoqing Pan and
  • Gefeng Xu
  • + 8 authors+ 3 authors

18 November 2025

Rainbow trout (Oncorhynchus mykiss) is an economically important fish species, in which the muscle nutritional composition of market-size fish can vary significantly due to differences in genetic background and breeding environments. This study emplo...

(This article belongs to the Special Issue Metabolic and Stress Responses in Aquatic Animals (2nd Edition))
  • Article
  • Open Access
3 Citations
1,494 Views
15 Pages

Assessment of Antibiotic Resistance and Microbial Contamination in Commercial Veterinary Probiotic Products

  • Shuo Guan,
  • Chunguang Wang,
  • Zongshu Zhang,
  • Mengfan Wang and ,
  • Xinghua Zhao and
  • Tie Zhang
  • + 1 author+ 0 author

17 November 2025

Probiotics are widely used as feed additives in livestock production, yet the overall safety of commercially available veterinary probiotics remains insufficiently assessed. In this study, 33 probiotic products marketed in Northern China were systema...

(This article belongs to the Section Microbiology)
  • Article
  • Open Access
4 Citations
1,158 Views
24 Pages

Multi-Omics Analysis Reveals Biaxial Regulatory Mechanisms of Cardiac Adaptation by Specialized Racing Training in Yili Horses

  • Tongliang Wang,
  • Mengying Li,
  • Wanlu Ren,
  • Jun Meng and ,
  • Xinkui Yao,
  • Hongzhong Chu,
  • Runchen Yao,
  • Manjun Zhai and
  • Yaqi Zeng
  • + 4 authors+ 0 author

17 November 2025

Yili horses undergo coordinated physiological adaptations across systems in response to customized training. This study aimed to clarify the molecular mechanisms of these adaptations by integrating analyses of cardiac function and multi-omics (lipido...

  • Article
  • Open Access
934 Views
17 Pages

How Wastewater Addition Reshapes Peatland Vegetation via Linked Abiotic and Biotic Changes

  • Yue Li,
  • Xue Wang,
  • Lianxi Sheng,
  • Chunguang He and
  • Haibo Jiang

17 November 2025

Peatlands, as globally important carbon sinks, are highly sensitive to human disturbances. The direct discharge or use of domestic sewage with different treatment gradients as peatland replenishment water affects plant communities, but how the plant...

  • Article
  • Open Access
5 Citations
1,748 Views
23 Pages

Impact of Particle Size on the Aerobic Decomposition and Fertilizer Efficiency of Corn Cobs: A Sustainable Waste-to-Resource Approach

  • Qian Liu,
  • Pengbing Wu,
  • Xingchi Guo,
  • Ying Qu and ,
  • Junyan Zheng,
  • Yuhe Xing,
  • Zhiyu Dong,
  • Wei Yu,
  • Guoyu Zhang and
  • Xu Zhang
  • + 5 authors+ 0 author

17 November 2025

The conversion of agricultural residues into high-value organic amendments is fundamental to sustainable farming systems. Corn cobs represent a widely available lignocellulosic resource; however, their rigid structural properties often hinder efficie...

  • Article
  • Open Access
2 Citations
1,577 Views
17 Pages

Modeling the Future Distribution of Trifolium repens L. in China: A MaxEnt Approach Under Climate Change Scenarios

  • Haojun Wang,
  • Qilin Liu,
  • Jinyu Shen,
  • Jiayu Ding and ,
  • Yu Zeng,
  • Zixin Zhou,
  • Xiangrong Yan,
  • Jianbo Zhang,
  • Xiao Ma and
  • Yi Xiong
  • + 7 authors+ 2 authors

17 November 2025

Trifolium repens L. is a protein-rich, versatile Leguminous lawn plant that is widely distributed across global temperate and subtropical regions. As an invasive species originating in Europe, its distribution in China extends from Xinjiang in the We...

(This article belongs to the Special Issue Impacts of Climate Change on Terrestrial Carbon Cycling and Biodiversity Across Spatial and Temporal Scales)
  • Article
  • Open Access
4 Citations
2,547 Views
15 Pages

Analysis of Pigmentation Changes in Bracts of Bougainvillea × buttiana ‘Miss Manila’ During Different Developmental Periods

  • Xiangdong Liu,
  • Yuwan Ma,
  • Jiawen Yan,
  • Yan Liu and ,
  • Yaqi Huang,
  • Siyin Deng,
  • Jiawen Dong and
  • Yulin Hu
  • + 3 authors+ 0 author

17 November 2025

Bougainvillea has large and vibrant-colored bracts, which are widely used in landscape gardening. In order to study the changing pattern of pigmentation and the expression of genes related to pigment synthesis during different developmental periods o...

(This article belongs to the Special Issue Advances in Tropical and Subtropical Plant Ecology and Physiology)
  • Article
  • Open Access
2 Citations
1,245 Views
12 Pages

Insecticidal Activity of Angelica archangelica Essential Oil and Transcriptomic Analysis of Sitophilus zeamais in Response to Oil Fumigation

  • Guochang Wang,
  • Xing Ge,
  • Dongbiao Lü,
  • Ziyue Zhang and ,
  • Li Wang,
  • Saili Sun,
  • Xiaoyi Jia,
  • Baizhong Zhang,
  • Kassen Kuanysh and
  • Hongliang Wang
  • + 6 authors+ 1 author

17 November 2025

Sitophilus zeamais is one of the most destructive pests of stored grains. Both adults and larvae penetrate and consume the grains, thereby diminishing the grain quality and nutritional value. We determined the chemical composition of Angelica archang...

(This article belongs to the Special Issue The Biology, Ecology, and Management of Plant Pests)
  • Article
  • Open Access
2 Citations
1,365 Views
24 Pages

Genome-Wide Identification and Expression Analysis of the PEPC Gene Family in Zanthoxylum armatum Reveals Potential Roles in Environmental Adaptation

  • Ruxin Xu,
  • Huamin Liu,
  • Chongyu Liu,
  • Maoqin Xia and ,
  • Dalan Feng,
  • Yongxing Zhu,
  • Chong Sun,
  • Xia Liu,
  • Mi Kuang and
  • Zexiong Chen
  • + 8 authors+ 3 authors

16 November 2025

Phosphoenolpyruvate carboxylase (PEPC) is a crucial enzyme in plant photosynthesis and stress responses, yet its gene family remained uncharacterized in Zanthoxylum armatum. This study presents the first genome-wide identification and comprehensive a...

(This article belongs to the Section Genetics and Genomics)
  • Article
  • Open Access
1,125 Views
13 Pages

Population Structure and Ecological Niches of Benthic Macroinvertebrates in the Upper Yarlung Zangbo River

  • Zepeng Zhang,
  • Hongyu Jin,
  • Shenhui Li,
  • Haipeng Wang and ,
  • Shitong Xing,
  • Wanqiao Lu and
  • Lei Li
  • + 2 authors+ 0 author

16 November 2025

The community structure and ecological niche of benthic macroinvertebrates in the upper Yarlung Zangbo River were analyzed in April and September 2023. The benthic macroinvertebrate community largely comprises aquatic insects, with Diptera accounting...

  • Article
  • Open Access
2 Citations
1,043 Views
18 Pages

16 November 2025

Beavers are classified as ecosystem engineers because their activities can significantly alter environmental conditions. Vegetation and landscape changes, based on a series of vegetation maps and satellite images between 1994 and 2022, were studied i...

  • Review
  • Open Access
1 Citations
2,304 Views
26 Pages

15 November 2025

Evolution is reticulate. Reticulation increases diversity and complexity on the different levels of the evolutionary hierarchy. In addition to the tendency for diversity and complexity to increase in unchecked evolutionary systems by ongoing divergen...

(This article belongs to the Section Evolutionary Biology)
  • Article
  • Open Access
2 Citations
1,722 Views
18 Pages

Genetic Diversity of Sweetpotato (Ipomoea batatas (L.) Lam.) from Portugal, Mozambique and Timor-Leste

  • Joana B. Guimarães,
  • Maria Cristina Simões-Costa,
  • Milton Pinho,
  • Celina Maria Godinho and ,
  • Paula Sá Pereira,
  • João Neves Martins,
  • Ana Ribeiro-Barros,
  • Pedro Talhinhas and
  • Maria Manuela Veloso
  • + 4 authors+ 0 author

15 November 2025

Portugal contributed to the global diffusion of sweetpotato (Ipomoea batatas L. Lam.). Although it is of minor importance on the Portuguese mainland, it is one of the most common crops in the Azores and Madeira archipelagos and is highly relevant in...

  • Article
  • Open Access
2 Citations
1,080 Views
12 Pages

Dietary Guanidinoacetic Acid Supplementation Improves Growth Performance of Plateau Yaks Through Plasma Metabolome Modulation

  • Yinjie You,
  • Li Zhang,
  • Lin Fu,
  • Xianwen Dong and ,
  • Zhongli Peng,
  • Yu Zeng,
  • Gaofu Wang,
  • Juncai Chen,
  • Yanhua Gao and
  • Jia Zhou
  • + 5 authors+ 0 author

15 November 2025

This study aimed to investigate the effects of dietary guanidinoacetic acid (GAA) supplementation on yak physiology by evaluating growth performance, serum biochemical indices and plasm metabolomic profiles to elucidate the underlying regulatory mech...

(This article belongs to the Special Issue Nutritional Physiology of Animals)
  • Article
  • Open Access
3 Citations
1,617 Views
18 Pages

15 November 2025

Microalgae of the genus Nannochloropsis are known for their ability to accumulate large amounts of lipids, particularly triacylglycerides (TAGs), when exposed to nitrogen-limiting conditions. This trait makes them promising candidates for biofuel pro...

  • Article
  • Open Access
2 Citations
916 Views
16 Pages

15 November 2025

A total of 304 bacterial strains were isolated from the Taklamakan Desert. Through screening, strain TRM82367 exhibited potent insecticidal activity against cotton aphids (Aphis gossypii) and was identified as Bacillus velezensis. To explore the prim...

(This article belongs to the Section Microbiology)
  • Review
  • Open Access
9 Citations
2,946 Views
19 Pages

In Vitro Culture of Avian Primordial Germ Cells: Established Methods and Future Directions

  • Jehan Nayga,
  • Elen Gócza,
  • Eszter Várkonyi and
  • Bence Lázár

14 November 2025

Primordial germ cells (PGCs) are the unipotent precursors of sperm and ova, responsible for transmitting hereditary information across generations. Their ability to be isolated and cultured in vitro has opened new horizons for avian biotechnology, sp...

(This article belongs to the Section Biotechnology)
  • Review
  • Open Access
1 Citations
2,041 Views
25 Pages

14 November 2025

Research on mammalian embryogenesis has been revolutionised by rapid technological and methodological advancements. This review seeks to synthesise historical and contemporary studies on mouse embryos to provide comprehensive conceptual frameworks of...

(This article belongs to the Special Issue Feature Papers on Developmental and Reproductive Biology)
  • Article
  • Open Access
1,025 Views
15 Pages

Effects of Clobetasol in an Aging Mouse Model of Spinal Cord Hemisection

  • Maria Ciuro,
  • Maria Sangiorgio,
  • Giuliano Cantone,
  • Carlo Fichera and ,
  • Valeria Cacciato,
  • Giampiero Leanza and
  • Rosario Gulino
  • + 2 authors+ 0 author

14 November 2025

Spinal cord injury leads to permanent neurological deficits, and aging further diminishes the plasticity and regenerative responses required for recovery. Activation of the Sonic hedgehog (Shh) pathway through the receptor Smoothened (Smo) has been p...

(This article belongs to the Section Neuroscience)
  • Article
  • Open Access
1 Citations
1,648 Views
23 Pages

Total Flavonoids of Rhizoma drynariae Enhance Bone Marrow Mesenchymal Stem Cell-Mediated Tendon–Bone Healing by Promoting Tissue Regeneration, Angiogenesis, and Modulation of Cytokine Expression

  • Gaoyuan Yang,
  • Yu Wang,
  • Xianyan Xie,
  • Ziyan Li and ,
  • Shuqi Qin,
  • Weitong Zhang,
  • Zixi Chenyuan,
  • Peizhong Cao,
  • Huiguo Wang and
  • Lin Zhu
  • + 5 authors+ 0 author

14 November 2025

(1) Objective: This study aimed to investigate the synergistic effect and underlying mechanisms of Total Flavonoids of Rhizoma drynariae (TFRD) in combination with Bone Marrow Mesenchymal Stem Cells (BMSCs) in the repair of tendon–bone injuries...

(This article belongs to the Special Issue Bone Mechanics: From Cells to Organs to Function)
  • Article
  • Open Access
1 Citations
2,301 Views
19 Pages

Melatonin Improves Intestinal Barrier Impairment in a Mouse Model of Autism Spectrum Disorder

  • Francesca Sulas,
  • Gaia Favero,
  • Sara Anna Bonini,
  • Claudio Lonati and ,
  • Daniela Pinto,
  • Maurizio Memo,
  • Fabio Rinaldi and
  • Rita Rezzani
  • + 3 authors+ 0 author

14 November 2025

Autism spectrum disorder (ASD) is a neurodevelopmental condition mainly characterized by social impairments and repetitive behaviors. An altered intestinal barrier morphology and increased transmucosal leaks have also been implicated in ASD; in fact,...

(This article belongs to the Special Issue Experimental Biology 100 Years After the Foundation of the Italian Society: A Celebratory Special Issue)
  • Article
  • Open Access
1 Citations
869 Views
17 Pages

14 November 2025

Long non-coding RNAs (lncRNAs) are crucial regulators in eukaryotic organisms, yet their roles in filamentous fungi, particularly in environmental adaptation and metabolic changes, remain largely unexplored. Here, we investigated the roles of lncRNAs...

(This article belongs to the Section Microbiology)
  • Article
  • Open Access
1 Citations
751 Views
17 Pages

PcNPF2.7 from the Xerophyte Pugionium cornutum Facilitates Root-to-Shoot NO3− Transport and Affects Na+ Transport Under Salt Stress

  • Peng-Fei Ren,
  • Fang-Zhen Wang,
  • Zhuo-Ma Deji,
  • Hao-Ran Liao and ,
  • Mei-Mei Cai,
  • Ke-Yan He,
  • Li Li,
  • Xiao-Xing Wei and
  • Qing Ma
  • + 4 authors+ 0 author

14 November 2025

Nitrate Excretion Transporter 1 (NAXT1/NPF2.7) is known to regulate NO3− transport in Arabidopsis, a salt-sensitive glycophyte that exhibits a significant reduction in the NO3− content under salt stress. However, its role in the NO3&minus...

(This article belongs to the Section Plant Science)
  • Article
  • Open Access
2 Citations
1,762 Views
16 Pages

Hypoglycemic Effect of Pleurotus citrinopileatus and Hericium erinaceus Buccal Tablets on Diabetic Mice

  • Zhongyi Yang,
  • Kailu Zhang,
  • Yan Liang,
  • Kexin Shi and ,
  • Jinqiang Ma,
  • Juan Yu,
  • Cunlong Lu,
  • Aimin Liu and
  • Xiancan Zhu
  • + 4 authors+ 0 author

14 November 2025

Diabetes mellitus poses a global health challenge, necessitating natural adjuvants with minimal side effects. The aims of this study were to optimize the concentrations of chromium (Cr), zinc (Zn), and germanium (Ge) in the liquid fermentation media...

(This article belongs to the Section Microbiology)
  • Article
  • Open Access
1,241 Views
21 Pages

Integrated Multi-Omics Analysis Reveals Stage-Specific Molecular Modules Regulating Uterine Function and Fecundity in Large White Pigs Across Reproductive Lifespan

  • Wenwu Chen,
  • Fang Yang,
  • Jingwen Liu,
  • Lei Yi and ,
  • Sui Liufu,
  • Kaiming Wang,
  • Yan Gong,
  • Zhi Li and
  • Haiming Ma
  • + 4 authors+ 0 author

13 November 2025

This study systematically explored the regulatory mechanisms of uterine function across four reproductive stages: sexual maturity sow (SMS), low-yield sow (LYS), high-yield sow (HYS), and culled sow (CS) in Large White (LW) pigs through integrated tr...

(This article belongs to the Section Developmental and Reproductive Biology)
  • Article
  • Open Access
2 Citations
1,258 Views
13 Pages

Afforestation Enhances Soil Ecosystem Multifunctionality by Improving Soil Quality and Enzyme Activities in Coastal Saline–Alkali Land

  • Jianni Sun,
  • Jiayi Yang,
  • Xiaoyi Wang,
  • Haifei Lu and ,
  • Tailin Zhong and
  • Haidong Xu
  • + 1 author+ 0 author

13 November 2025

Afforestation is critical for enhancing soil quality and optimizing land use in coastal saline–alkali regions. However, the dynamics of soil quality and ecosystem multifunctionality (EMF) during afforestation, as well as their coupling relation...

(This article belongs to the Section Ecology)
  • Article
  • Open Access
3 Citations
1,401 Views
24 Pages

13 November 2025

High-fat diets are commonly used in eel aquaculture to reduce protein costs, but excessive fat intake can impair intestine health. This study investigated whether soy isoflavones (SIFs), an emulsifying additive, could mitigate the negative effects of...

  • Article
  • Open Access
1 Citations
877 Views
17 Pages

Temporal Change Rate in Sound Velocity Caused by Ultrasonic Heating for Evaluation of Steatotic Liver

  • Machi Itsubo,
  • Yume Kobayashi,
  • Masaki Yamamoto,
  • Shinji Takayanagi and
  • Iwaki Akiyama

13 November 2025

Steatotic liver diseases are increasing globally, with metabolic dysfunction-associated steatohepatitis potentially causing irreversible fibrosis progression. This study focuses on an ultrasonic diagnostic method for steatotic liver disease based on...

(This article belongs to the Section Biophysics)
  • Article
  • Open Access
3 Citations
1,245 Views
17 Pages

Transcriptomic and Metabolomic Mechanisms Underlying Adaptive Differentiation of Black Soldier Fly Larvae Induced by Regional Food Waste Domestication

  • Bin Zhang,
  • Rencan Yang,
  • Zaimei Yuan,
  • Hongren Su and ,
  • Jingyi Shi,
  • Shichun He,
  • Sifan Dai,
  • Dawei Sun,
  • Zhiyong Zhao and
  • Dongwang Wu
  • + 6 authors+ 1 author

12 November 2025

Black soldier flies (Hermetia illucens) are widely used in organic waste bioconversion, and their adaptive capacity to region-specific food waste is critical for efficient application. This study aimed to explore the molecular mechanisms underlying t...

(This article belongs to the Section Ecology)
  • Article
  • Open Access
1 Citations
1,483 Views
26 Pages

Less Severe Inflammation in Cyclic GMP–AMP Synthase (cGAS)-Deficient Mice with Rabies, Impact of Mitochondrial Injury, and Gut–Brain Axis

  • Pannatat Areekul,
  • Thansita Bhunyakarnjanarat,
  • Sakolwan Suebnuson,
  • Kollawat Somsri and ,
  • Somchanok Trakultritrung,
  • Kris Taveethavornsawat,
  • Tewin Tencomnao,
  • Siwaporn Boonyasuppayakorn and
  • Asada Leelahavanichkul
  • + 4 authors+ 0 author

12 November 2025

Activation of cGAS, a receptor recognizing cytosolic DNA, in macrophages might be associated with rabies (an RNA virus) through mitochondrial damage. A similar mortality rate was observed between cGAS-deficient (cGAS-/-) and wild-type (WT) mice post-...

(This article belongs to the Special Issue The Role of Gut Microbiota in Human Metabolism and Disease)

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Biology - ISSN 2079-7737