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Biosensors, Volume 9, Issue 4 (December 2019) – 34 articles
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Cover Story (view full-size image) Noble metal nanoclusters (NMNCs) with sizes comparable to the Fermi wavelength of an electron [...] Read more. Noble metal nanoclusters (NMNCs) with sizes comparable to the Fermi wavelength of an electron exhibit fluorescence in correlation with the number of atoms in the cluster, which has potential applications in diverse areas, including electroluminescent display, solid-state lighting, and biomedical imaging. However, the conventional synthesis of such fluorescent NMNCs traditionally employs tedious and complex synthesis processes, uses harsh reaction conditions, and utilizes organic solvents that may hinder their biomedical applications. Herein, we propose a facile biomineralization process to produce highly fluorescent Pt-NMNCs in aqueous medium using a multistimulus responsive, biomimetic, intrinsically disordered protein polymer, Rec1-resilin. We demonstrate that Rec1-resilin acts concurrently as the host, reducing agent, and stabilizer of the blue-green fluorescent Pt-NMNCs once they are being formed.View this paper.