Next Article in Journal
FRET Microscopy in Yeast
Previous Article in Journal
P-N Junction-Based Si Biochips with Ring Electrodes for Novel Biosensing Applications
Open AccessReview

Polarization Induced Electro-Functionalization of Pore Walls: A Contactless Technology

Univ. Grenoble Alpes, CEA, CNRS, IRIG, SyMMES, F-38000 Grenoble, France
LAAS-CNRS, Université de Toulouse, 31400 Toulouse, France
Department of Chemistry, University of Oxford, South Parks Road, Oxford OX1 3QZ, UK
Univ. Grenoble Alpes, CEA, LETI, MINATEC Campus, 38000 Grenoble, France
CEA/DRF/IRIG, Centre de Thérapie Cellulaire, Hôpital Saint-Louis, F-75010 Paris, France
Institute for Advanced Biosciences, Grenoble Alpes University/INSERM U1209/CNRS UMR5309, 38700 La Tronche, France
University Bordeaux, CNRS, Bordeaux INP, ISM, UMR 5255, F-33400 Talence, France
Univ. Grenoble Alpes, CEA, INSERM, IRIG, BGE, F-38000 Grenoble, France
Author to whom correspondence should be addressed.
Biosensors 2019, 9(4), 121;
Received: 30 July 2019 / Revised: 19 September 2019 / Accepted: 27 September 2019 / Published: 11 October 2019
This review summarizes recent advances in micro- and nanopore technologies with a focus on the functionalization of pores using a promising method named contactless electro-functionalization (CLEF). CLEF enables the localized grafting of electroactive entities onto the inner wall of a micro- or nano-sized pore in a solid-state silicon/silicon oxide membrane. A voltage or electrical current applied across the pore induces the surface functionalization by electroactive entities exclusively on the inside pore wall, which is a significant improvement over existing methods. CLEF’s mechanism is based on the polarization of a sandwich-like silicon/silicon oxide membrane, creating electronic pathways between the core silicon and the electrolyte. Correlation between numerical simulations and experiments have validated this hypothesis. CLEF-induced micro- and nanopores functionalized with antibodies or oligonucleotides were successfully used for the detection and identification of cells and are promising sensitive biosensors. This technology could soon be successfully applied to planar configurations of pores, such as restrictions in microfluidic channels. View Full-Text
Keywords: nanopore; micropore; CLEF; biosensing; electro-functionalization; contactless nanopore; micropore; CLEF; biosensing; electro-functionalization; contactless
Show Figures

Figure 1

MDPI and ACS Style

Bouchet-Spinelli, A.; Descamps, E.; Liu, J.; Ismail, A.; Pham, P.; Chatelain, F.; Leïchlé, T.; Leroy, L.; Marche, P.N.; Raillon, C.; Roget, A.; Roupioz, Y.; Sojic, N.; Buhot, A.; Haguet, V.; Livache, T.; Mailley, P. Polarization Induced Electro-Functionalization of Pore Walls: A Contactless Technology. Biosensors 2019, 9, 121.

AMA Style

Bouchet-Spinelli A, Descamps E, Liu J, Ismail A, Pham P, Chatelain F, Leïchlé T, Leroy L, Marche PN, Raillon C, Roget A, Roupioz Y, Sojic N, Buhot A, Haguet V, Livache T, Mailley P. Polarization Induced Electro-Functionalization of Pore Walls: A Contactless Technology. Biosensors. 2019; 9(4):121.

Chicago/Turabian Style

Bouchet-Spinelli, Aurélie; Descamps, Emeline; Liu, Jie; Ismail, Abdulghani; Pham, Pascale; Chatelain, François; Leïchlé, Thierry; Leroy, Loïc; Marche, Patrice Noël; Raillon, Camille; Roget, André; Roupioz, Yoann; Sojic, Neso; Buhot, Arnaud; Haguet, Vincent; Livache, Thierry; Mailley, Pascal. 2019. "Polarization Induced Electro-Functionalization of Pore Walls: A Contactless Technology" Biosensors 9, no. 4: 121.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop