Special Issue "Bioelectric Sensors"

A special issue of Biosensors (ISSN 2079-6374).

Deadline for manuscript submissions: 31 December 2019.

Special Issue Editor

Prof. Dr. Spyridon Kintzios
E-Mail Website
Guest Editor
Department of Biotechnology, Agricultural University of Athens, Athens, Greece
Tel. +302105294292
Interests: biosensors; biotechnology; cell culture; cell technology
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Bioelectric sensors are unique diagnostic principles and technologies. Although they share many traits with electrochemical sensors, especially regarding the common features of instrumentation, they are focused on the measurement of the electric properties of biorecognition elements as a reflection of cellular, biological, and biomolecular functions in a rapid, very sensitive, and often non-invasive manner. Bioelectric sensors offer a plethora of options in terms both of assay targets (molecules, cells, organs, and organisms) and methodological approaches (e.g., potentiometry, impedance spectrometry, and patch-clamp electrophysiology). Irrespective of the method of choice, “bioelectric profiling” is being rapidly established as a superior concept for a number of applications, including in vitro toxicity, signal transduction, real-time medical diagnostics, environmental risk assessment, and drug development. This Special Issue is the first that is exclusively dedicated to the advanced and emerging concepts and technologies of bioelectric sensors. Topics include, but are not restricted to, bioelectric sensors for single cell analysis, electrophysiological olfactory and volatile organic compounds sensors, impedimetric biosensors, microbial fuel cell biosensors, and implantable autonomous bioelectric micro- and nano-sensors. Also of interest are the innovative approaches offering a high throughput analytical capacity, point-of-care/portable and wireless instrumentation, and intelligent bioelectric sensing platforms. Research papers, short communications, and reviews are all welcome. If the author is interested in submitting a review, it would be helpful to discuss this with the guest-editor before submission.

Prof. Dr. Spyridon Kintzios
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Bioelectric
  • Bioelectric profiling
  • Biosensor
  • Electrophysiology
  • Impedimetric
  • Impedance spectrometry
  • Implantable
  • Medical diagnostics
  • Microbial fuel cell
  • Microsensors
  • Nanosensors
  • Olfactory
  • Patch-Clamp
  • Potentiometry
  • Signal transduction
  • Single cell analysis
  • Vocs
  • Toxicology

Published Papers (4 papers)

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Research

Open AccessCommunication
Detection of Superoxide Alterations Induced by 5-Fluorouracil on HeLa Cells with a Cell-Based Biosensor
Biosensors 2019, 9(4), 126; https://doi.org/10.3390/bios9040126 - 16 Oct 2019
Abstract
Background: In vitro cell culture monitoring can be used as an indicator of cellular oxidative stress for the assessment of different chemotherapy agents. Methods: A cell-based bioelectric biosensor was used to detect alterations in superoxide levels in the culture medium of HeLa cervical [...] Read more.
Background: In vitro cell culture monitoring can be used as an indicator of cellular oxidative stress for the assessment of different chemotherapy agents. Methods: A cell-based bioelectric biosensor was used to detect alterations in superoxide levels in the culture medium of HeLa cervical cancer cells after treatment with the chemotherapeutic agent 5-fluorouracil (5-FU). The cytotoxic effects of 5-fluorouracil on HeLa cells were assessed by the MTT proliferation assay, whereas oxidative damage and induction of apoptosis were measured fluorometrically by the mitochondria-targeted MitoSOX™ Red and caspase-3 activation assays, respectively. Results: The results of this study indicate that 5-FU differentially affects superoxide production and caspase-3 activation when applied in cytotoxic concentrations against HeLa cells, while superoxide accumulation is in accordance with mitochondrial superoxide levels. Our findings suggest that changes in superoxide concentration could be detected with the biosensor in a non-invasive and rapid manner, thus allowing a reliable estimation of oxidative damage due to cell apoptosis. Conclusions: These findings may be useful for facilitating future high throughput screening of different chemotherapeutic drugs with a cytotoxic principle based on free radical production. Full article
(This article belongs to the Special Issue Bioelectric Sensors)
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Open AccessArticle
P-N Junction-Based Si Biochips with Ring Electrodes for Novel Biosensing Applications
Biosensors 2019, 9(4), 120; https://doi.org/10.3390/bios9040120 - 11 Oct 2019
Abstract
In this work, we report on the impedance of p-n junction-based Si biochips with gold ring top electrodes and unstructured platinum bottom electrodes which allows for counting target biomaterial in a liquid-filled ring top electrode region. The systematic experiments on p-n junction-based Si [...] Read more.
In this work, we report on the impedance of p-n junction-based Si biochips with gold ring top electrodes and unstructured platinum bottom electrodes which allows for counting target biomaterial in a liquid-filled ring top electrode region. The systematic experiments on p-n junction-based Si biochips fabricated by two different sets of implantation parameters (i.e. biochips PS5 and BS5) are studied, and the comparable significant change of impedance characteristics in the biochips in dependence on the number of bacteria suspension, i.e., Lysinibacillus sphaericus JG-A12, in Deionized water with an optical density at 600 nm from OD600 = 4–16 in the electrode ring region is demonstrated. Furthermore, with the help of the newly developed two-phase electrode structure, the modeled capacitance and resistance parameters of the electrical equivalent circuit describing the p-n junction-based biochips depend linearly on the number of bacteria in the ring top electrode region, which successfully proves the potential performance of p-n junction-based Si biochips in observing the bacterial suspension. The proposed p-n junction-based biochips reveal perspective applications in medicine and biology for diagnosis, monitoring, management, and treatment of diseases. Full article
(This article belongs to the Special Issue Bioelectric Sensors)
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Open AccessArticle
Wireless Direct Microampere Current in Wound Healing: Clinical and Immunohistological Data from Two Single Case Reports
Biosensors 2019, 9(3), 107; https://doi.org/10.3390/bios9030107 - 05 Sep 2019
Abstract
Chronic pressure ulcers are hard-to-heal wounds that decrease the patient’s quality of life. Wireless Micro Current Stimulation (WMCS) is an innovative, non-invasive, similar to electrode-based electrostimulation (ES) technology, that generates and transfers ions that are negatively-charged to the injured tissue, using accessible air [...] Read more.
Chronic pressure ulcers are hard-to-heal wounds that decrease the patient’s quality of life. Wireless Micro Current Stimulation (WMCS) is an innovative, non-invasive, similar to electrode-based electrostimulation (ES) technology, that generates and transfers ions that are negatively-charged to the injured tissue, using accessible air gases as a transfer medium. WMCS is capable of generating similar tissue potentials, as electrode-based ES, for injured tissue. Here, through immunohistochemistry, we intended to characterize the induced tissue healing biological mechanisms that occur during WMCS therapy. Two single cases of bedridden due to serious stroke white men with chronic non-healing pressure ulcers have been treated with WMCS technology. WMCS suppresses inflammatory responses by decreasing the aggregation of granulocytes, followed by stimulating myofibroblastic activity and a new formation of collagen fibers, as depicted by immunohistochemistry. As a result, WMCS provides a special adjunct or stand-alone therapy choice for chronic and non-healing injuries, similar to electrode-based ES, but with added (i.e., contactless) benefits towards its establishment as a routine clinical wound healing regime. Full article
(This article belongs to the Special Issue Bioelectric Sensors)
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Open AccessArticle
Reflectance-Based Organic Pulse Meter Sensor for Wireless Monitoring of Photoplethysmogram Signal
Biosensors 2019, 9(3), 87; https://doi.org/10.3390/bios9030087 - 10 Jul 2019
Abstract
This paper compares the structural design of two organic biosensors that minimize power consumption in wireless photoplethysmogram (PPG) waveform monitoring. Both devices were fabricated on the same substrate with a red organic light-emitting diode (OLED) and an organic photodiode (OPD). Both were designed [...] Read more.
This paper compares the structural design of two organic biosensors that minimize power consumption in wireless photoplethysmogram (PPG) waveform monitoring. Both devices were fabricated on the same substrate with a red organic light-emitting diode (OLED) and an organic photodiode (OPD). Both were designed with a circular OLED at the center of the device surrounded by OPD. One device had an OLED area of 0.06 cm2, while the other device had half the area. The gap distance between the OLED and OPD was 1.65 mm for the first device and 2 mm for the second. Both devices had an OPD area of 0.16 cm2. We compared the power consumption and signal-to-noise ratio (SNR) of both devices and evaluated the PPG signal, which was successfully collected from a fingertip. The reflectance-based organic pulse meter operated successfully and at a low power consumption of 8 µW at 18 dB SNR. The device sent the PPG waveforms, via Bluetooth low energy (BLE), to a PC host at a maximum rate of 256 kbps data throughput. In the end, the proposed reflectance-based organic pulse meter reduced power consumption and improved long-term PPG wireless monitoring. Full article
(This article belongs to the Special Issue Bioelectric Sensors)
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