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A Bottom-Up Approach for Developing Aptasensors for Abused Drugs: Biosensors in Forensics

1
Department of Biochemistry, Institute of Natural and Applied Sciences, Ege University, 35100 Bornova, Izmir, Turkey
2
Department of Biochemistry, Faculty of Science, Ege University, 35100 Bornova, Izmir, Turkey
3
Department of Mental Health and Diseases, Faculty of Medicine, Ege University, 35100 Bornova, Izmir, Turkey
4
Central Research Testing and Analysis Laboratory Research and Application Center, Ege University, 35100 Bornova, Izmir, Turkey
*
Authors to whom correspondence should be addressed.
Biosensors 2019, 9(4), 118; https://doi.org/10.3390/bios9040118
Received: 15 September 2019 / Revised: 27 September 2019 / Accepted: 30 September 2019 / Published: 1 October 2019
(This article belongs to the Special Issue The Potential of (bio)sensors for the Forensic Sciences)
Aptamer-based point-of-care (POC) diagnostics platforms may be of substantial benefit in forensic analysis as they provide rapid, sensitive, user-friendly, and selective analysis tools for detection. Aptasensors have not yet been adapted commercially. However, the significance of the applications of aptasensors in the literature exceeded their potential. Herein, in this review, a bottom-up approach is followed to describe the aptasensor development and application procedure, starting from the synthesis of the corresponding aptamer sequence for the selected analyte to creating a smart surface for the sensitive detection of the molecule of interest. Optical and electrochemical biosensing platforms, which are designed with aptamers as recognition molecules, detecting abused drugs are critically reviewed, and existing and possible applications of different designs are discussed. Several potential disciplines in which aptamer-based biosensing technology can be of greatest value, including forensic drug analysis and biological evidence, are then highlighted to encourage researchers to focus on developing aptasensors in these specific areas. View Full-Text
Keywords: point-of-care (POC); custom-tailored aptamers; optical biosensors; electrochemical biosensors; forensic sciences point-of-care (POC); custom-tailored aptamers; optical biosensors; electrochemical biosensors; forensic sciences
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MDPI and ACS Style

Aydindogan, E.; Balaban, S.; Evran, S.; Coskunol, H.; Timur, S. A Bottom-Up Approach for Developing Aptasensors for Abused Drugs: Biosensors in Forensics. Biosensors 2019, 9, 118.

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