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Journal of Clinical Medicine, Volume 10, Issue 17

2021 September-1 - 272 articles

Cover Story: Introduction: Obstructive sleep apnea is a common disorder characterized by recurrent interruption of breathing during sleep, resulting in varying degrees of oxygen desaturation, arousal from sleep, and, consequently, poor sleep quality and excessive daytime sleepiness. The consequences of anatomic and autonomic events that occur in obstructive sleep apnea extend into the waking hours, including a heightened risk of cardiac rhythm disorders. In this review, we will discuss what is presently known about the relationship between obstructive sleep apnea and cardiac rhythm disturbances, covering epidemiology, pathophysiology, clinical interactions, and the impact of obstructive sleep apnea treatment on rhythm-related outcomes. View this paper.
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Articles (272)

  • Article
  • Open Access
7 Citations
3,568 Views
14 Pages

The Occurrence of Pain-Induced Depression Is Different between Rat Models of Inflammatory and Neuropathic Pain

  • Yung-Chi Hsu,
  • Kuo-Hsing Ma,
  • Shu-Lin Guo,
  • Bo-Feng Lin,
  • Chien-Sung Tsai and
  • Chun-Chang Yeh

6 September 2021

Various pain conditions may be associated with depressed mood. However, the effect of inflammatory or neuropathic pain on depression-like behavior and its associated time frame has not been well established in rat models. This frontward study investi...

  • Article
  • Open Access
7 Citations
3,330 Views
17 Pages

Impact of the 18F-FDG-PET/MRI on Metastatic Staging in Patients with Hepatocellular Carcinoma: Initial Results from 104 Patients

  • Mathilde Vermersch,
  • Sébastien Mulé,
  • Julia Chalaye,
  • Athena Galletto Pregliasco,
  • Berivan Emsen,
  • Giuliana Amaddeo,
  • Aurélien Monnet,
  • Alto Stemmer,
  • Laurence Baranes and
  • Alain Luciani
  • + 3 authors

6 September 2021

Optimal HCC therapeutic management relies on accurate tumor staging. Our aim was to assess the impact of 18F-FDG-WB-PET/MRI on HCC metastatic staging, compared with the standard of care CT-CAP/liver MRI combination, in patients with HCC referred on a...

  • Article
  • Open Access
19 Citations
3,459 Views
11 Pages

Role of Serum E-Selectin as a Biomarker of Infection Severity in Coronavirus Disease 2019

  • Alessandra Oliva,
  • Emanuele Rando,
  • Dania Al Ismail,
  • Massimiliano De Angelis,
  • Francesca Cancelli,
  • Maria Claudia Miele,
  • Raissa Aronica,
  • Vera Mauro,
  • Federica Di Timoteo and
  • Claudio M. Mastroianni
  • + 1 author

6 September 2021

Introduction: E-selectin is a recognized marker of endothelial activation; however, its place in Coronavirus Disease 2019 (COVID-19) has not been fully explored. Aims of the study are to compare sE-selectin values among the Intensive Care Unit (ICU)-...

  • Article
  • Open Access
12 Citations
3,709 Views
15 Pages

Anakinra versus Baricitinib: Different Strategies for Patients Hospitalized with COVID-19

  • José A García-García,
  • Marta Pérez-Quintana,
  • Consuelo Ramos-Giráldez,
  • Isabel Cebrián-González,
  • María L Martín-Ponce,
  • José del Valle-Villagrán,
  • María A Navarro-Puerto,
  • Jorge Sánchez-Villegas,
  • Rocío Gómez-Herreros and
  • José A Mira-Escarti
  • + 13 authors

6 September 2021

Background: Immunomodulatory drugs have been used in patients with severe COVID-19. The objective of this study was to evaluate the effects of two different strategies, based either on an interleukin-1 inhibitor, anakinra, or on a JAK inhibitor, such...

  • Feature Paper
  • Article
  • Open Access
1 Citations
3,225 Views
8 Pages

Comparison of Safety and Efficiency between Tiger-2 Catheter with Right Radial Artery Access and Judkins Catheter with Left Radial Artery Access

  • Katarzyna Klimek,
  • Mateusz Świątek,
  • Konrad Klocek,
  • Michał Tworek,
  • Maciej Zwolski,
  • Krzysztof Milewski and
  • Adam Janas

6 September 2021

We sought to compare the safety and efficiency of Tiger-2 in the right radial and Judkins catheter in the left radial access. We retrospectively collected data of 487 patients, involving 172 patients after coronary angiography with Judkins on the lef...

  • Article
  • Open Access
17 Citations
3,028 Views
14 Pages

Is Obesity a Risk or Protective Factor for Open-Angle Glaucoma in Adults? A Two-Database, Asian, Matched-Cohort Study

  • Wei-Dar Chen,
  • Li-Ju Lai,
  • Kang-Lung Lee,
  • Tzeng-Ji Chen,
  • Chia-Yen Liu and
  • Yao-Hsu Yang

6 September 2021

Obesity contributes to multiple systemic disorders; however, extensive discussion regarding obesity and open-angle glaucoma (OAG) remains limited, and conclusions in the existing literature diverge. This study aims to analyze the risk of OAG among ob...

  • Article
  • Open Access
2 Citations
2,844 Views
15 Pages

The Prognostic Role of Right Ventricular Stroke Work Index during Liver Transplantation

  • Young Hyun Jeong,
  • Seong-Mi Yang,
  • Hyeyeon Cho,
  • Jae-Woo Ju,
  • Hwan Suk Jang,
  • Ho-Jin Lee and
  • Won Ho Kim

6 September 2021

Right heart-associated hemodynamic parameters including intraoperative pulmonary vascular resistance (PVR) were reported to be associated with patient survival after liver transplantation. We investigated whether intraoperative stroke work indexes of...

  • Article
  • Open Access
9 Citations
3,883 Views
11 Pages

Psychometric Validation of the Cardiff Wound Impact Schedule Questionnaire in a Spanish Population with Diabetic Foot Ulcer

  • Minerva Granado-Casas,
  • Dolores Martinez-Gonzalez,
  • Montserrat Martínez-Alonso,
  • Montserrat Dòria,
  • Nuria Alcubierre,
  • Joan Valls,
  • Josep Julve,
  • José Verdú-Soriano and
  • Didac Mauricio

6 September 2021

Diabetic foot ulcers (DFU) negatively affect the quality of life (QoL) of people with diabetes. The Cardiff Wound Impact Schedule (CWIS) questionnaire has been designed to measure the QoL of people with chronic foot wounds. However, no studies have b...

  • Article
  • Open Access
15 Citations
3,543 Views
17 Pages

Portomesenteric Vein Thrombosis after Bariatric Surgery: An Online Survey

  • Francesco Maria Carrano,
  • Sylvia Weiner,
  • Moustafa Elshafei,
  • Saleem Ahmed,
  • Toghrul Talishinskiy,
  • Valeria Tognoni,
  • Kamal Mahawar and
  • Nicola Di Lorenzo

6 September 2021

Portomesenteric vein thrombosis (PMVT) is a rare post-operative complication of bariatric procedures, occurring in between 0.3% and 1% of cases. A structured questionnaire consisting of 27 items was available online to members of the International Fe...

  • Article
  • Open Access
59 Citations
13,238 Views
21 Pages

6 September 2021

In this study, we aimed to explain the interplay mechanism between stress, life satisfaction, and coping styles among university students. A cohort study was performed during the first (wave 1; W1) and second (wave 2; W2) waves of the Coronavirus dis...

  • Article
  • Open Access
8 Citations
2,813 Views
9 Pages

The Relationship between Serum Uric Acid and Ejection Fraction of the Left Ventricle

  • Vlad-Sabin Ivan,
  • Roxana Buzas,
  • Adina-Flavia Cuțina Morgovan,
  • Paul Ciubotaru,
  • Melania Ardelean,
  • Daniel Goje,
  • Ciprian Ilie Roșca,
  • Romulus Timar and
  • Daniel Lighezan

6 September 2021

Study basis: As a byproduct of protein metabolism, serum uric acid is a controversial risk factor and is the focus of several recent studies in the field of cardiovascular disease. Whether serum uric acid is involved in the development of these patho...

  • Article
  • Open Access
10 Citations
5,192 Views
16 Pages

Dissociation and Suicidality in Eating Disorders: The Mediating Function of Body Image Disturbances, and the Moderating Role of Depression and Anxiety

  • Yael Doreen Lewis,
  • Shirley Kapon,
  • Adi Enoch-Levy,
  • Amit Yaroslavsky,
  • Eliezer Witztum and
  • Daniel Stein

6 September 2021

In patients with eating disorders (EDs), elevated dissociation may increase the risk of suicide. Bodily related disturbances, depression, and anxiety may intervene in the association between dissociation and suicidality. In this study we aimed to exa...

  • Article
  • Open Access
7 Citations
5,853 Views
19 Pages

The Acute Effects of Aerobic Exercise on Nocturnal and Pre-Sleep Arousal in Patients with Unipolar Depression: Preplanned Secondary Analysis of a Randomized Controlled Trial

  • Gavin Brupbacher,
  • Thea Zander-Schellenberg,
  • Doris Straus,
  • Hildburg Porschke,
  • Denis Infanger,
  • Markus Gerber,
  • Roland von Känel and
  • Arno Schmidt-Trucksäss

6 September 2021

Unipolar depression is associated with insomnia and autonomic arousal. The aim of this study was to quantify the effect of a single bout of aerobic exercise on nocturnal heart rate variability and pre-sleep arousal in patients with depression. This s...

  • Article
  • Open Access
27 Citations
11,825 Views
11 Pages

Reduction of Phantom Limb Pain and Improved Proprioception through a TSR-Based Surgical Technique: A Case Series of Four Patients with Lower Limb Amputation

  • Alexander Gardetto,
  • Eva-Maria Baur,
  • Cosima Prahm,
  • Vinzenz Smekal,
  • Johannes Jeschke,
  • Gerfried Peternell,
  • Michael T. Pedrini and
  • Jonas Kolbenschlag

6 September 2021

Four patients underwent targeted sensory reinnervation (TSR), a surgical technique in which a defined skin area is first selectively denervated and then surgically reinnervated by another sensory nerve. In our case, either the area of the lateral fem...

  • Article
  • Open Access
3 Citations
2,701 Views
10 Pages

Clinical Significance of Variable Histomorphologic Findings Related to Mucosal Inflammation in Negative Appendectomy

  • Euno Choi,
  • Youngeun Yoo,
  • Ji Min Kim,
  • Sun Hee Sung,
  • Dakeun Lee and
  • Sanghui Park

6 September 2021

The aim of the study was to investigate the clinical significance of various histomorphologic findings related to mucosal inflammation in negative appendectomy. We reviewed histopathologic findings of 118 negative appendectomies and correlated them w...

  • Article
  • Open Access
13 Citations
5,455 Views
14 Pages

6 September 2021

There is a lack of guidelines for physical exercise in patients with myasthenia gravis (MG). A few pilot studies have shown that exercise can be safely applied to patients with MG. However, how physical exercise affects body composition, disease func...

  • Article
  • Open Access
7 Citations
5,022 Views
10 Pages

Radioactive Iodine Treatment and the Risk of Long-Term Cardiovascular Morbidity and Mortality in Thyroid Cancer Patients: A Nationwide Cohort Study

  • Chun-Hao Kao,
  • Chi-Hsiang Chung,
  • Wu-Chien Chien,
  • Daniel Hueng-Yuan Shen,
  • Li-Fan Lin,
  • Chuang-Hsin Chiu,
  • Cheng-Yi Cheng,
  • Chien-An Sun and
  • Ping-Ying Chang

6 September 2021

(1) Background: This study aimed to investigate the association between radioactive iodine (RAI) and long-term cardiovascular disease (CVD) morbidity/mortality in thyroid cancer. (2) Methods: The study was conducted using data from the Taiwan Nationa...

  • Review
  • Open Access
42 Citations
9,724 Views
18 Pages

5 September 2021

Non-Obstructive Azoospermia (NOA) affects about 1% of men in the general population and is characterized by clinical heterogeneity implying the involvement of several different acquired and genetic factors. NOA men are at higher risk to be carriers o...

  • Article
  • Open Access
9 Citations
5,006 Views
12 Pages

5 September 2021

Troponin I is a biomarker for cardiac injury in children. The role of troponin I in neonatal Hypoxic–Ischemic encephalopathy (HIE) may have valuable clinical implications. Troponin I levels were measured within 6 h of birth to determine their relatio...

  • Article
  • Open Access
18 Citations
3,489 Views
14 Pages

A Multicenter Randomized Controlled Prospective Study to Assess Efficacy of Laparoscopic Electrochemotherapy in the Treatment of Locally Advanced Pancreatic Cancer

  • Francesco Izzo,
  • Vincenza Granata,
  • Roberta Fusco,
  • Valeria D’Alessio,
  • Antonella Petrillo,
  • Secondo Lastoria,
  • Mauro Piccirillo,
  • Vittorio Albino,
  • Andrea Belli and
  • Raffaele Palaia
  • + 5 authors

5 September 2021

Background: Eighty percent of patients with pancreatic adenocarcinoma present a locally advanced or metastatic disease at diagnosis and are not eligible for surgery if not with palliative intent. In cases of locally advanced disease (LAPC), the combi...

  • Article
  • Open Access
6 Citations
2,620 Views
10 Pages

Direct Lateral Corpectomy and Reconstruction Using an Expandable Cage Improves Local Kyphosis but Not Global Sagittal Alignment

  • Hidetomi Terai,
  • Shinji Takahashi,
  • Hiroyuki Yasuda,
  • Sadahiko Konishi,
  • Takafumi Maeno,
  • Hiroshi Kono,
  • Akira Matsumura,
  • Takashi Namikawa,
  • Minori Kato and
  • Hiroaki Nakamura
  • + 4 authors

5 September 2021

Recently, an expandable cage equipped with rectangular footplates has been used for anterior vertebral replacement in osteoporotic vertebral fracture (OVF). However, the postoperative changes in global alignment have not been elucidated. The purpose...

  • Article
  • Open Access
1 Citations
3,332 Views
10 Pages

The Surgical Management of Brain Metastases in Non-Small Cell Lung Cancer (NSCLC): Identification of the Early Laboratory and Clinical Determinants of Survival

  • Matthias Schneider,
  • Niklas Schäfer,
  • Christian Bode,
  • Lars Eichhorn,
  • Frank A. Giordano,
  • Erdem Güresir,
  • Muriel Heimann,
  • Yon-Dschun Ko,
  • Jennifer Landsberg and
  • Patrick Schuss
  • + 7 authors

5 September 2021

Background: Brain metastases (BM) indicate advanced states of cancer disease and cranial surgery represents a common treatment modality. In the present study, we aimed to identify the risk factors for a reduced survival in patients receiving a surgic...

  • Article
  • Open Access
11 Citations
3,681 Views
11 Pages

Adverse Features of Rectourethral Fistula Requiring Extirpative Surgery and Permanent Dual Diversion: Our Experience and Recommendations

  • Francisco E. Martins,
  • João Felicio,
  • Tiago Ribeiro Oliveira,
  • Natália Martins,
  • Vítor Oliveira and
  • Artur Palmas

5 September 2021

Introduction: To report a series of men with a rectourethral fistula (RUF) resulting from pelvic cancer treatments and explore their therapeutic differences and impact on the functional outcomes and quality of life highlighting the adverse features t...

  • Review
  • Open Access
21 Citations
4,021 Views
22 Pages

COVID-19 in Liver Transplant Recipients: A Systematic Review

  • Chiara Becchetti,
  • Sarah Gabriela Gschwend,
  • Jean-François Dufour and
  • Vanessa Banz

5 September 2021

Liver transplant (LT) recipients are considered a vulnerable population amidst the COVID-19 pandemic. To date, available data have been heterogeneous and scarce. Therefore, we conducted a systematic literature review identifying English-language arti...

  • Article
  • Open Access
3 Citations
2,994 Views
13 Pages

Primary Stability in Hip Revision Arthroplasty: Comparison of the Stability of Cementless Fixed Augments on a Modular Acetabular Cage System with and without Cranial Straps

  • Max Jaenisch,
  • Hendrik Kohlhof,
  • Dieter Christian Wirtz,
  • Frank Alexander Schildberg,
  • Nicholas A. Beckmann,
  • Jan Philippe Kretzer,
  • Mareike Schonhoff and
  • Sebastian Jäger

4 September 2021

The goal of this study is to evaluate the primary stability of a cementless augment-and-modular-cage system with and without the addition of cranial straps in a standardized in vitro setting. As the surrogate parameter for the evaluation of primary s...

  • Article
  • Open Access
2 Citations
2,763 Views
10 Pages

Induced Dipoles and Possible Modulation of Wireless Effects in Implanted Electrodes. Effects of Implanting Insulated Electrodes on an Animal Test to Screen Antidepressant Activity

  • Laura Perez-Caballero,
  • Hector Carceller,
  • Juan Nacher,
  • Vicent Teruel-Marti,
  • Eulalia Pujades,
  • Nieves Casañ-Pastor and
  • Esther Berrocoso

4 September 2021

There is evidence that Deep Brain Stimulation (DBS) produces health benefits in patients even before initiating stimulation. Furthermore, DBS electrode insertion in rat infralimbic cortex (ILC) provokes antidepressant-like effects before stimulation,...

  • Review
  • Open Access
9 Citations
3,938 Views
12 Pages

Transcatheter Tricuspid Valve-in-Valve Procedure—An Illustrative Case Report and Review

  • Márcio José Montenegro da Costa,
  • Edgard Freitas Quintella,
  • Luiz Kohn,
  • Maximiliano Otero Lacoste,
  • Gustavo Lycurgo Leite,
  • Leonardo Hadid,
  • Dany David Kruczan,
  • Ricardo Zajdenverg,
  • Hugo de Castro Sabino and
  • Paulo Antônio Marra da Motta

4 September 2021

Severe tricuspid commitment is no longer understood as merely a marker of disease but is now widely thought of as a significant contributor to cardiac morbidity and mortality. However, isolated tricuspid valve surgery remains rare and to this day con...

  • Article
  • Open Access
6 Citations
2,532 Views
8 Pages

Analysis of Patient Factors Affecting In Vitro Characteristics of Subacromial Bursal Connective Tissue Progenitor Cells during Rotator Cuff Repair

  • Daichi Morikawa,
  • Benjamin C. Hawthorne,
  • Mary Beth R. McCarthy,
  • Nicholas Bellas,
  • Jeremiah D. Johnson,
  • Maxwell T. Trudeau,
  • Kyle V. Murphy,
  • Michael R. Mancini,
  • Matthew R. LeVasseur and
  • Augustus D. Mazzocca
  • + 1 author

4 September 2021

Unsatisfactory failure rates following rotator cuff (RC) repair have led orthopaedic surgeons to explore biological augmentation of the healing enthesis. The subacromial bursa (SB) contains abundant connective tissue progenitor cells (CTPs) that may...

  • Article
  • Open Access
14 Citations
3,990 Views
11 Pages

Balloon-Expandable versus Self-Expandable Valves in Transcatheter Aortic Valve Implantation: Complications and Outcomes from a Large International Patient Cohort

  • Astrid C. van Nieuwkerk,
  • Raquel B Santos,
  • Leire Andraka,
  • Didier Tchetche,
  • Fabio S. de Brito,
  • Marco Barbanti,
  • Ran Kornowski,
  • Azeem Latib,
  • Augusto D’Onofrio and
  • Ronak Delewi
  • + 16 authors

4 September 2021

Background: Both balloon-expandable (BE) and self-expandable (SE) valves for transcatheter aortic valve implantation (TAVI) are broadly used in clinical practice. However, adequately powered randomized controlled trials comparing these two valve desi...

  • Article
  • Open Access
20 Citations
4,272 Views
12 Pages

Computed Tomography Structured Reporting in the Staging of Lymphoma: A Delphi Consensus Proposal

  • Vincenza Granata,
  • Silvia Pradella,
  • Diletta Cozzi,
  • Roberta Fusco,
  • Lorenzo Faggioni,
  • Francesca Coppola,
  • Roberta Grassi,
  • Nicola Maggialetti,
  • Duccio Buccicardi and
  • Vittorio Miele
  • + 13 authors

4 September 2021

Structured reporting (SR) in radiology is becoming increasingly necessary and has been recognized recently by major scientific societies. This study aims to build structured CT-based reports for lymphoma patients during the staging phase to improve c...

  • Article
  • Open Access
6 Citations
3,017 Views
13 Pages

Metabolic Effects of Gastrectomy and Duodenal Bypass in Early Gastric Cancer Patients with T2DM: A Prospective Single-Center Cohort Study

  • Young Ki Lee,
  • Eun Kyung Lee,
  • You Jin Lee,
  • Bang Wool Eom,
  • Hong Man Yoon,
  • Young-Il Kim,
  • Soo Jeong Cho,
  • Jong Yeul Lee,
  • Chan Gyoo Kim and
  • Keun Won Ryu
  • + 7 authors

4 September 2021

We evaluated the metabolic effects of gastrectomies and endoscopic submucosal dissections (ESDs) in early gastric cancer (EGC) patients with type 2 diabetes mellitus (T2DM). Forty-one EGC patients with T2DM undergoing gastrectomy or ESD were prospect...

  • Article
  • Open Access
1 Citations
9,311 Views
10 Pages

Proposal of Treatment Strategy for Pedicle Fractures of the C2: An Analysis of 49 Cases

  • Jong-Beom Park,
  • Sung-Kyu Kim,
  • Hyoung-Yeon Seo,
  • Jong-Hyun Ko and
  • Tae-Min Hong

3 September 2021

Spine surgeons often confuse C2 pedicle fractures (PFs) with pars interarticularis fractures. In addition, little information is available about the characteristics and treatment strategies for C2 PFs. We sought to investigate the characteristics of...

  • Article
  • Open Access
5 Citations
7,230 Views
12 Pages

Psychiatric History and Overactive Bladder Symptom Severity in Ambulatory Urogynecological Patients

  • Artur Rogowski,
  • Maria Krowicka-Wasyl,
  • Ewa Chotkowska,
  • Tomasz Kluz,
  • Andrzej Wróbel,
  • Dominika Berent,
  • Paweł Mierzejewski,
  • Halina Sienkiewicz-Jarosz,
  • Adam Wichniak and
  • Przemyslaw Bienkowski
  • + 3 authors

3 September 2021

Introduction and hypothesis: A link between psychiatric comorbidities and overactive bladder symptomatology has been suggested by preclinical and clinical studies. Given this, we hypothesized that a psychiatric history and current treatment with psyc...

  • Article
  • Open Access
16 Citations
3,738 Views
9 Pages

Assessment of Anxiety, Depression, Attitude, and Coping Strategies of the Egyptian Population during the COVID-19 Pandemic

  • Ghaydaa A. Shehata,
  • Romany Gabra,
  • Sara Eltellawy,
  • Mohamed Elsayed,
  • Dina Elsayed Gaber and
  • Hatem A. Elshabrawy

3 September 2021

Background: The COVID-19 pandemic has imposed several challenges on different populations all around the world, with stress being identified as one of the major challenges. This study aims to investigate the impact of COVID-19-induced stress on the p...

  • Article
  • Open Access
9 Citations
3,320 Views
13 Pages

Does Health Literacy Reinforce Disease Knowledge Gain? A Prospective Observational Study of Hungarian COPD Patients

  • Orsolya Papp-Zipernovszky,
  • Márta Csabai,
  • Peter J. Schulz and
  • János T. Varga

3 September 2021

We set out to measure the health literacy (HL) of COPD patients using the Short Test of Functional Health Literacy (S-TOFHLA), perception-based screening questions (BHLS), and a specific disease knowledge test (COPD-Q). Our main focus is the relation...

  • Article
  • Open Access
12 Citations
2,880 Views
11 Pages

The Incidence of Inflammatory Bowel Disease in the Paediatric Population in the District of Lower Silesia, Poland

  • Elzbieta Krzesiek,
  • Anna Kofla-Dlubacz,
  • Katarzyna Akutko and
  • Andrzej Stawarski

3 September 2021

The incidence of IBD has been rising over the last decades. The trend applies not only to well-developed countries but also to the regions with limited number of cases so far, e.g., Asia or Middle East. Aim: The aim of the study was to determine the...

  • Article
  • Open Access
4 Citations
2,845 Views
15 Pages

Differential Impact of Cytochrome 2C19 Allelic Variants on Three Different Platelet Function Tests in Clopidogrel-Treated Patients

  • Renske H. Olie,
  • Rachelle R. K. Hensgens,
  • Petal A. H. M. Wijnen,
  • Leo F. Veenstra,
  • Bianca T. A. de Greef,
  • Minka J. A. Vries,
  • Paola E. J. van der Meijden,
  • Jurriën M. ten Berg,
  • Hugo ten Cate and
  • Yvonne M. C. Henskens
  • + 1 author

3 September 2021

On-treatment platelet reactivity in clopidogrel-treated patients can be measured with several platelet function tests (PFTs). However, the agreement between different PFTs is only slight to moderate. Polymorphisms of the CYP2C19 gene have an impact o...

  • Review
  • Open Access
6 Citations
3,923 Views
12 Pages

3 September 2021

Purpose: To review novel findings in research with ultra-widefield imaging for analysis of peripheral manifestations in macular degeneration (AMD). We introduce the evolving widefield imaging modalities while summarizing the analytical techniques use...

  • Review
  • Open Access
36 Citations
5,706 Views
16 Pages

Targeting Mitochondria and Metabolism in Acute Kidney Injury

  • Ying Li,
  • Mark Hepokoski,
  • Wanjun Gu,
  • Tatum Simonson and
  • Prabhleen Singh

3 September 2021

Acute kidney injury (AKI) significantly contributes to morbidity and mortality in critically ill patients. AKI is also an independent risk factor for the development and progression of chronic kidney disease. Effective therapeutic strategies for AKI...

  • Article
  • Open Access
13 Citations
3,447 Views
13 Pages

Does a Vegetarian Diet Affect the Levels of Myokine and Adipokine in Prepubertal Children?

  • Jadwiga Ambroszkiewicz,
  • Joanna Gajewska,
  • Joanna Mazur,
  • Witold Klemarczyk,
  • Grażyna Rowicka,
  • Mariusz Ołtarzewski,
  • Małgorzata Strucińska and
  • Magdalena Chełchowska

3 September 2021

Myokines are cytokines secreted by muscle and exert autocrine, paracrine, or endocrine effects. Myokines mediate communication between muscle and other organs, including adipose tissue. The aim of the study was to assess serum myokines and their rela...

  • Review
  • Open Access
38 Citations
7,847 Views
8 Pages

Fatigue in Systemic Lupus Erythematosus: An Update on Its Impact, Determinants and Therapeutic Management

  • Lou Kawka,
  • Aurélien Schlencker,
  • Philippe Mertz,
  • Thierry Martin and
  • Laurent Arnaud

3 September 2021

Fatigue is a complex and multifactorial phenomenon which is often neglected by clinicians. The aim of this review was to analyze the impact, determinants and management of fatigue in patients with Systemic Lupus Erythematosus (SLE). Fatigue is one of...

  • Article
  • Open Access
13 Citations
3,860 Views
18 Pages

3 September 2021

Acromegaly is a rare disease caused by overproduction of growth hormone (GH) by a pituitary adenoma, and consequently increased insulin-like growth factor 1 (IGF-1) concentration. The GH/IGF-1 axis and immune cells interactions are hypothesized to be...

  • Article
  • Open Access
5 Citations
3,230 Views
10 Pages

Persistent Resistant Hypertension Has Worse Renal Outcomes in Chronic Kidney Disease than that Resolved in Two Years: Results from the KNOW-CKD Study

  • Su-Hyun Song,
  • Young-Jin Kim,
  • Hong-Sang Choi,
  • Chang-Seong Kim,
  • Eun-Hui Bae,
  • Curie Ahn,
  • Kook-Hwan Oh,
  • Sue-Kyung Park,
  • Kyu-Beck Lee and
  • Soo-Wan Kim
  • + 3 authors

3 September 2021

Apparent treatment-resistant hypertension (ATRH) is closely related to chronic kidney disease (CKD); however, the long-term outcomes and the effects of improvement in ATRH in patients with CKD are not well understood. We evaluated the relationship be...

  • Article
  • Open Access
8 Citations
2,835 Views
9 Pages

3 September 2021

Background: Chronic kidney disease (CKD) is a common medical problem in patients worldwide, with an increasing prevalence of patients with end-stage kidney disease (ESKD) requiring renal replacement therapy (RRT). In patients requiring RRT for more t...

  • Article
  • Open Access
9 Citations
3,601 Views
13 Pages

Model of Care for Microelimination of Hepatitis C Virus Infection among People Who Inject Drugs

  • Francesco Giuseppe Foschi,
  • Alberto Borghi,
  • Alberto Grassi,
  • Arianna Lanzi,
  • Elvira Speranza,
  • Teo Vignoli,
  • Lucia Napoli,
  • Deanna Olivoni,
  • Michele Sanza and
  • on behalf of MITH Group
  • + 7 authors

3 September 2021

Background: People who inject drugs (PWID) are the largest group at risk for HCV infection. Despite the direct acting antivirals (DAA) advancements, HCV elimination has been hindered by real-life difficulties in PWID. Aims: This study aimed to assess...

  • Article
  • Open Access
20 Citations
6,099 Views
17 Pages

A Complete Digital Workflow for Planning, Simulation, and Evaluation in Orthognathic Surgery

  • Sang-Jeong Lee,
  • Ji-Yong Yoo,
  • Sang-Yoon Woo,
  • Hoon Joo Yang,
  • Jo-eun Kim,
  • Kyung-Hoe Huh,
  • Sam-Sun Lee,
  • Min-Suk Heo,
  • Soon Jung Hwang and
  • Won-Jin Yi

3 September 2021

The purpose of this study was to develop a complete digital workflow for planning, simulation, and evaluation for orthognathic surgery based on 3D digital natural head position reproduction, a cloud-based collaboration platform, and 3D landmark-based...

  • Article
  • Open Access
7 Citations
4,041 Views
11 Pages

Multi-Institutional Study of Dorsal Onlay Urethroplasty of the Membranous Urethra after Endoscopic Prostate Procedures: Operative Results, Continence, Erectile Function and Patient Reported Outcomes

  • Javier C. Angulo,
  • Juan F. Dorado,
  • Connor G. Policastro,
  • Francisco E. Martins,
  • Keith Rourke,
  • Erick A. Ramírez,
  • Jay Simhan,
  • Eric S. Li,
  • Paul Rusilko and
  • Dmitriy Nikolavsky
  • + 4 authors

2 September 2021

(1) Background: To critically evaluate dorsal onlay buccal mucosal graft urethroplasty (DOBMGU) for posterior urethral stenosis repair following transurethral resection and other endoscopic prostate procedures. (2) Methods: A retrospective multi-inst...

  • Article
  • Open Access
10 Citations
3,907 Views
11 Pages

Head-to-Head Comparison of Different Software Solutions for AVC Quantification Using Contrast-Enhanced MDCT

  • Ruben Evertz,
  • Sebastian Hub,
  • Sören J. Backhaus,
  • Torben Lange,
  • Karl Toischer,
  • Johannes T. Kowallick,
  • Gerd Hasenfuß and
  • Andreas Schuster

2 September 2021

Aortic valve calcification (AVC) in aortic stenosis patients has diagnostic and prognostic implications. Little is known about the interchangeability of AVC obtained from different multidetector computed tomography (MDCT) software solutions. Contrast...

  • Article
  • Open Access
3 Citations
2,354 Views
24 Pages

A Target for Increased Mortality Risk in Critically Ill Patients: The Concept of Perpetuity

  • Jarrod M. Mosier,
  • Julia M. Fisher,
  • Cameron D. Hypes,
  • Edward J. Bedrick,
  • Elizabeth Salvagio Campbell,
  • Karen Lutrick and
  • Charles B. Cairns

2 September 2021

Background: Emergency medicine is acuity-based and focuses on time-sensitive treatments for life-threatening diseases. Prolonged time in the emergency department, however, is associated with higher mortality in critically ill patients. Thus, we explo...

  • Article
  • Open Access
3 Citations
2,539 Views
10 Pages

2 September 2021

Background: Dobutamine stress echocardiography (DSE) has limited application in systemic sclerosis (SSc). We examined DSE usefulness in revealing pulmonary arterial hypertension (PAH) in selected SSc patients whose resting echocardiography for pulmon...

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J. Clin. Med. - ISSN 2077-0383