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Vaccines, Volume 13, Issue 3

March 2025 - 127 articles

Cover Story: Bovine respiratory syncytial virus (BRSV) is a major pathogen in calves, responsible for severe respiratory outbreaks. Its high mutation rate leads to genetic diversity, potentially affecting vaccine efficacy. In this study, we identified strains from subgroups II and VIII circulating in Wallonia, Belgium, with subgroup VIII being documented for the first time in the country. Current vaccines are based on strains from subgroups II and III, raising questions about their effectiveness, particularly against subgroup VIII. The continuous evolution of BRSV highlights the need for sustained surveillance to guide vaccine strategies. Given its widespread distribution, monitoring viral diversity in other countries is crucial for effective disease control. View this paper
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Articles (127)

  • Article
  • Open Access
1,455 Views
14 Pages
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Stakeholders Perspectives on the Introduction of an Additional Injectable Vaccine Under the Universal Immunization Programme in India

  • Pawan Kumar,
  • Rashmi Mehra,
  • Arindam Ray,
  • Amrita Kumari,
  • Kapil Singh,
  • Rhythm Hora,
  • Amanjot Kaur,
  • Seema S. Koshal,
  • Syed F. Quadri and
  • Shyam Kumar Singh
  • + 2 authors
Vaccines2025, 13(3), 334;https://doi.org/10.3390/vaccines13030334

20 March 2025

Introduction: In 2023, India’s National Technical Advisory Group on Immunization (NTAGI) recommended the inclusion of typhoid conjugate vaccine (TCV) in the Universal Immunization Programme (UIP). However, introducing TCV, an additional injecta...

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  • Article
  • Open Access
1 Citations
1,768 Views
13 Pages
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Pooled Analysis of the Effect of Pre-Existing Ad5 Neutralizing Antibodies on the Immunogenicity of Adenovirus Type 5 Vector-Based COVID-19 Vaccine from Eight Clinical Trials

  • Wenqing Liu,
  • Yuqing Li,
  • Xiaolong Li,
  • Feiyu Wang,
  • Runjie Qi,
  • Tao Zhu and
  • Jingxin Li
Vaccines2025, 13(3), 333;https://doi.org/10.3390/vaccines13030333

20 March 2025

Background: Pre-existing adenovirus immunity restricts the utilization of adenovirus-vectored vaccines. The current study aims to conduct a pooled analysis of eight clinical trials to evaluate the influence of pre-existing Ad5 neutralizing antibodies...

Full Article
  • Systematic Review
  • Open Access
2,139 Views
15 Pages
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Comparative Analysis of Health Economic Evaluations for Different Influenza Vaccines and Vaccination Strategies in China: A Systematic Review

  • Fanxu Kong,
  • Li Cai,
  • Jiayi Zhang,
  • Huijie Zhu,
  • Zhibin Peng,
  • Jiandong Zheng,
  • Yaming Zheng and
  • Hai Fang
Vaccines2025, 13(3), 332;https://doi.org/10.3390/vaccines13030332

20 March 2025

Objective: This study systematically reviews health economic evaluations of influenza vaccines in China and synthesizes the evidence on different vaccine categories. Methods: We searched databases, including the China Hospital Knowledge Database, Wan...

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  • Article
  • Open Access
1 Citations
1,762 Views
17 Pages
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Application of Humanized MHC Transgenic Mice in the Screening of HLA–Restricted T Cell Epitopes for Influenza Vaccines

  • Yuwei Wei,
  • Keyu Sun,
  • Xuelian Han,
  • Yali Sun,
  • Jiejie Zhang,
  • Yuan Wang,
  • Qi Yin,
  • Tiantian Yang,
  • Kai Yuan and
  • Min Li
  • + 1 author
Vaccines2025, 13(3), 331;https://doi.org/10.3390/vaccines13030331

20 March 2025

Background: Annual influenza epidemics pose a significant burden on the global healthcare system. The currently available vaccines mainly induce the production of neutralizing antibodies against hemagglutinin and neuraminidase, which are prone to ant...

Full Article
  • Review
  • Open Access
2 Citations
4,206 Views
25 Pages
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Exploring CD169+ Macrophages as Key Targets for Vaccination and Therapeutic Interventions

  • Rianne G. Bouma,
  • Aru Z. Wang and
  • Joke M. M. den Haan
Vaccines2025, 13(3), 330;https://doi.org/10.3390/vaccines13030330

20 March 2025

CD169 is a sialic acid-binding immunoglobulin-like lectin (Siglec-1, sialoadhesin) that is expressed by subsets of tissue-resident macrophages and circulating monocytes. This receptor interacts with α2,3-linked Neu5Ac on glycoproteins as well a...

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  • Article
  • Open Access
1,419 Views
13 Pages
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Interplay Between Viral Shedding, Age, and Symptoms in Individual Infectivity of COVID-19 Breakthrough Infections in Households

  • Shuaibing Dong,
  • Ying Sun,
  • Shuyu Ni,
  • Yi Tian,
  • Zhaomin Feng,
  • Lei Jia,
  • Xiaoli Wang,
  • Daitao Zhang,
  • Quanyi Wang and
  • Tim K. Tsang
  • + 1 author
Vaccines2025, 13(3), 329;https://doi.org/10.3390/vaccines13030329

19 March 2025

Background/Objectives: Understanding the factors influencing breakthrough infections following COVID-19 vaccination is critical for disease prevention, especially in households where transmission risks are high. Factors such as age, symptoms, living...

Full Article
  • Article
  • Open Access
5 Citations
3,551 Views
16 Pages
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Immunogenicity and Safety of the Bivalent Respiratory Syncytial Virus Prefusion F Subunit Vaccine in Immunocompromised or Renally Impaired Adults

  • Natalia Castillo Almeida,
  • Lalitha Parameswaran,
  • Elliot N. DeHaan,
  • Hayley Wyper,
  • Farah Rahman,
  • Qin Jiang,
  • Wen Li,
  • Michael Patton,
  • Maria Maddalena Lino and
  • Zaynah Majid-Mahomed
  • + 11 authors
Vaccines2025, 13(3), 328;https://doi.org/10.3390/vaccines13030328

19 March 2025

Background/Objectives: Individuals with immunocompromising conditions are at high risk of developing severe respiratory syncytial virus (RSV) illness. This phase 3, single-arm study assessed the safety and immunogenicity of the bivalent RSV prefusion...

Full Article
  • Article
  • Open Access
3 Citations
3,794 Views
25 Pages
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An mRNA Vaccine for Herpes Zoster and Its Efficacy Evaluation in Naïve/Primed Murine Models

  • Linglei Jiang,
  • Wenshuo Zhou,
  • Fei Liu,
  • Wenhui Li,
  • Yan Xu,
  • Zhenwei Liang,
  • Man Cao,
  • Li Hou,
  • Pengxuan Liu and
  • Feifei Wu
  • + 8 authors
Vaccines2025, 13(3), 327;https://doi.org/10.3390/vaccines13030327

19 March 2025

Background/Objectives: An overwhelming burden to clinics, herpes zoster (HZ), or shingles, is a painful disease that occurs frequently among aged individuals with a varicella-zoster virus (VZV) infection history. The cause of shingles is the reactiva...

Full Article
  • Article
  • Open Access
1 Citations
1,701 Views
10 Pages
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Cell-Based Relative Potency of a Respiratory Syncytial Virus mRNA Vaccine Correlates with In Vivo Immunogenicity

  • Katrina Feller,
  • Hesham Nawar,
  • Liping Song,
  • Amanda Abrams,
  • Liang Shang,
  • Ashley Gruber,
  • Tatyana Yun and
  • Hualin Helen Li
Vaccines2025, 13(3), 326;https://doi.org/10.3390/vaccines13030326

19 March 2025

Background/Objectives: Potency is a critical quality attribute for vaccine development as well as clinical drug product (DP) lot release and stability testing. Animal studies have the potential to offer conclusive insights about the potency of vaccin...

Full Article
  • Article
  • Open Access
1,363 Views
19 Pages
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Determinants of Ukrainian Mothers’ Intentions to Vaccinate Their Children in Poland: A Cross-Sectional Study

  • Katarzyna Lewtak,
  • Joanna Mazur,
  • Harriet Dwyer,
  • Agnieszka Sochoń-Latuszek,
  • Anastasiya Atif,
  • Tomasz Maciejewski and
  • Dorota Kleszczewska
Vaccines2025, 13(3), 325;https://doi.org/10.3390/vaccines13030325

19 March 2025

Background/Objectives: In 2022, the full-scale invasion in Ukraine forced over 6 million Ukrainians, primarily mothers and children, to seek safety outside of the country. This massive influx has posed a significant challenge to the Polish healthcare...

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