Table of Contents
Antioxidants, Volume 8, Issue 3 (March 2019)
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Cover Story (view full-size image) Pulmonary vascular remodeling in pulmonary hypertension is characterized by increased [...] Read more. Pulmonary vascular remodeling in pulmonary hypertension is characterized by increased muscularization. Shown here are lung sections from a control normoxic (left) and chronically hypoxic (right) rat with pulmonary hypertension, stained with either antibodies against alpha smooth muscle actin (red) or DAPI nuclear stain (blue). Increased reactive oxygen species production by NAPDH oxidases (Nox), among other sources, contributes to pathological muscular remodeling. The crystal structure of the dehydrogenase domain of one Nox isoform (Nox5) is shown. View this paper.