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Antioxidants 2019, 8(3), 61; https://doi.org/10.3390/antiox8030061

Water-soluble CoQ10 as A Promising Anti-aging Agent for Neurological Dysfunction in Brain Mitochondria

Biological Process of Aging, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo 173-0015, Japan
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Received: 30 January 2019 / Revised: 19 February 2019 / Accepted: 8 March 2019 / Published: 11 March 2019
(This article belongs to the Special Issue CoQ10 in Longevity)
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Abstract

Mitochondrial function has been closely associated with normal aging and age-related diseases. Age-associated declines in mitochondrial function, such as changes in oxygen consumption rate, cytochrome c oxidase activity of complex IV, and mitochondrial coenzyme Q (CoQ) levels, begin as early as 12 to 15 months of age in male mouse brains. Brain mitochondrial dysfunction is accompanied by increased accumulation of phosphorylated α-synuclein in the motor cortex and impairment of motor activities, which are similar characteristics of Parkinson’s disease. However, these age-associated defects are completely rescued by the administration of exogenous CoQ10 to middle-aged mice via its water solubilization by emulsification in drinking water. Further efforts to develop strategies to enhance the biological availability of CoQ10 to successfully ameliorate age-related brain mitochondrial dysfunction or neurodegenerative disorders may provide a promising anti-aging agent. View Full-Text
Keywords: aging; brain mitochondria; water-soluble CoQ10; motor impairment; α-synuclein; oxygen consumption aging; brain mitochondria; water-soluble CoQ10; motor impairment; α-synuclein; oxygen consumption
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Takahashi, M.; Takahashi, K. Water-soluble CoQ10 as A Promising Anti-aging Agent for Neurological Dysfunction in Brain Mitochondria. Antioxidants 2019, 8, 61.

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