Special Issue "CoQ10 in Longevity"

A special issue of Antioxidants (ISSN 2076-3921).

Deadline for manuscript submissions: 30 January 2019

Special Issue Editor

Guest Editor
Dr. Guillermo López Lluch

Centro Andaluz de Biología del Desarrollo and CIBERER, Instituto de Salud Carlos III, Universidad Pablo de Olavide-CSIC-JA, Sevilla, Spain
Website | E-Mail
Interests: aging; metabolism; antioxidants; calorie restriction; physical activity; exercise; neurodegeneration; muscle; liver; immunology

Special Issue Information

Dear Colleagues,

Coenzyme Q (CoQ) is essential in cell metabolism and antioxidant protection in organisms. It has been associated with aging progression. Decrease in the levels of CoQ during aging has been suggested in many models and also in humans. Further, the redox ratio between reduced and oxidized form has been also associated with aging in humans. However, their role in aging and longevity is not completely clear. Being an essential component of aerobic metabolism in all the organisms and being a key component in membrane antioxidant system and in cholesterol oxidation protection, maintenance of CoQ levels can be related with longevity and with the progression of aging-related diseases. In this Special Issue we want to highlight the importance of CoQ in longevity and its role in the progression of aging-related diseases. Contributions including reviews about the importance of this essential factor are welcome.

Dr. Guillermo López Lluch
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 550 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Coenzyme Q
  • Longevity
  • Aging
  • Metabolism
  • Mitochondria
  • Cholesterol
  • Neurodegeneration
  • Cardiovascular disease
  • Sarcopenia
  • Inmunosenescence
  • Model organisms

Published Papers (1 paper)

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Research

Open AccessArticle Coenzyme Q10 Modulates Remodeling Possibly by Decreasing Angiotensin-Converting Enzyme in Patients with Acute Coronary Syndrome
Antioxidants 2018, 7(8), 99; https://doi.org/10.3390/antiox7080099
Received: 2 June 2018 / Revised: 18 July 2018 / Accepted: 20 July 2018 / Published: 25 July 2018
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Abstract
The study aims to examine the effects of coenzyme Q10, (a bioenergetic antioxidant), on the indexes of left ventricular remodeling, oxidative damage, and angiotensin-converting enzyme (ACE) level after acute myocardial infarction (AMI) with left ventricular dysfunction. In a double blind, randomized, placebo-controlled, parallel
[...] Read more.
The study aims to examine the effects of coenzyme Q10, (a bioenergetic antioxidant), on the indexes of left ventricular remodeling, oxidative damage, and angiotensin-converting enzyme (ACE) level after acute myocardial infarction (AMI) with left ventricular dysfunction. In a double blind, randomized, placebo-controlled, parallel group study (a retrospective analysis of an earlier trial) in 55 patients with left ventricular ejection fraction <50% after AMI, the effects of coenzyme Q10 (120 mg/day) or placebo were studied for 24 weeks. Two-dimensional echocardiography was performed at discharge, (approximately 5–10 days after admission) and at 6 months after AMI. The results revealed that wall thickness opposite the site of infarction decreased from (mean ± standard deviation (SD)) 12.2 ± 2.0 mm to 10.0 ± 1.8 mm with coenzyme Q10 compared with 12.8 ± 2.2 mm to 13.3 ± 2.3 mm with placebo (p < 0.01). Left ventricular mass changed from 236 ± 72 g to 213 ± 61 g with coenzyme Q10 compared with 230 ± 77 g to 255 ± 86 g with placebo (p < 0.01). Treatment with coenzyme Q10 also prevented alteration of sphericity index which is a ratio of the long and short axis of the left ventricle (which changed from 1.61 ± 0.28 to 1.63 ± 0.30 with coenzyme Q10 compared with 1.61 ± 0.32 to 1.41 ± 0.31 with placebo (p < 0.05)). Coenzyme Q10 also prevented alteration of the wall thickening abnormality at the infarct site, which changed from 9.4 ± 3.0 cm2 to 9.1 ± 2.8 cm2 compared with 10.1 ± 3.1 to 13.7 ± 4.2 cm2 with placebo (p < 0.05). End diastolic and systolic volumes also showed significant reduction with coenzyme Q10 compared to placebo. The serum level of ACE showed significant decline in the coenzyme Q10 group compared to the control group. Treatment with coenzyme Q10 early after AMI causes attenuation of left ventricular remodeling and decreases the serum ACE level in patients with left ventricular dysfunction. Full article
(This article belongs to the Special Issue CoQ10 in Longevity)
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