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Resveratrol Anti-Obesity Effects: Rapid Inhibition of Adipocyte Glucose Utilization

Institute of Metabolic and Cardiovascular Diseases, INSERM, UMR1048, Team 1, 31342 Toulouse, France
I2MC, University of Toulouse, UMR1048, Paul Sabatier University, 31432 Toulouse, CEDEX 4, France
Department of Pharmacy, Faculty of Health Sciences, Universidad San Jorge, 50830 Villanueva de Gállego (Zaragoza), Spain
Instituto Agroalimentario de Aragón-IA2, CITA-Universidad de Zaragoza, 50013 Zaragoza, Spain
Cardiovascular Research Institute, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
Department of Fundamental Biology and Health Sciences, University of the Balearic Islands, 07122 Palma, Spain
Balearic Islands Health Research Institute (IdISBa), 07122 Palma, Spain
Author to whom correspondence should be addressed.
Antioxidants 2019, 8(3), 74;
Received: 27 February 2019 / Revised: 19 March 2019 / Accepted: 22 March 2019 / Published: 26 March 2019
(This article belongs to the Special Issue Natural Products in Health Promotion and Disease Prevention)
PDF [1519 KB, uploaded 26 March 2019]


Studies in animal models of diabetes and obesity have shown that resveratrol mitigates complications of metabolic diseases, beyond those resulting from oxidative stress. Furthermore, results obtained with cultured preadipocytes have also revealed that prolonged resveratrol treatment impairs adipogenesis. Considering the role of adipocytes in the hypertrophy of fat stores, and keeping in mind that insulin is the main trigger of excessive energy storage during post-prandial periods, the present study aimed to investigate how short-term effects of resveratrol can limit glucose disposal in a gut-adipose tissue axis. We found that resveratrol exhibits a more potent inhibitory capacity towards α-glucosidase than pancreatic lipase activity. Resveratrol also rapidly blunts glucose transport in mature fat cells by counteracting the effect of insulin and insulin-like lipogenic agents. Within two hours, resveratrol also inhibited the incorporation of glucose into lipids of adipocytes, which was unaffected by membrane cholesterol depletion. Moreover, the comparison between adipocytes with invalidated semicarbazide-sensitive amine oxidase activity and their control, or between resveratrol and several inhibitors, did not indicate that the recently described interaction of resveratrol with amine oxidases was involved in its antilipogenic effect. Caffeine and piceatannol, previously said to interact with glucose carriers, also inhibit lipogenesis in adipocytes, whereas other antioxidant phytochemicals do not reproduce such an antilipogenic effect. This study highlights the diverse first steps by which resveratrol impairs excessive fat accumulation, indicating that this natural molecule and its derivatives deserve further studies to develop their potential anti-obesity properties. View Full-Text
Keywords: adipose cells; obesity; amine oxidases; hydrogen peroxide; polyphenols; lipogenesis adipose cells; obesity; amine oxidases; hydrogen peroxide; polyphenols; lipogenesis

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Carpéné, C.; Les, F.; Cásedas, G.; Peiro, C.; Fontaine, J.; Chaplin, A.; Mercader, J.; López, V. Resveratrol Anti-Obesity Effects: Rapid Inhibition of Adipocyte Glucose Utilization. Antioxidants 2019, 8, 74.

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