H₂S in Redox Signaling

Dear Colleagues,

Hydrogen sulfide (H₂S) has emerged as a signaling molecule regulating various cellular and physiological processes important in health and disease. While our understanding of the molecular mechanisms underlying H₂S action is hampered by significant gaps, recent findings shed light on its mechanism of action in cellular redox signaling and maintenance of redox homeostasis. H₂S reacts with oxidized cysteine residues and metal centers that function as switches in various redox signaling pathways, and also with reactive nitrogen and oxygen species forming reactive intermediates with potential roles in redox signaling. Moreover, H₂S regulates key components in antioxidantive pathways and alters cellular ROS levels and provides cytoprotection in various model systems of oxidative stress. A better understanding of H₂S role in cellular redox signaling pathways will move the field forward and provide opportunities for therapeutic efforts to treat diseases involving redox imbalance.

This Special Issue welcomes original research papers and reviews to expand our understanding and perspective on all aspects of H₂S biochemistry and its role in cellular redox signaling in physiological and pathological processes. Special interests include: mechanistic insight into H₂S-signaling including persulfidation, its interaction with transition metals, reactive oxygen and nitrogen species; H2S-induced regulation of mitochondrial energetics, ROS production, thiol redox homeostasis, and antioxidative systems; mechanistic insight into H₂S-induced modulation of stress response pathways; and regulation of H₂S metabolism and tissue polysulfide pools.

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