Natural Antioxidants and Metabolic Diseases, 2nd Edition

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 10 April 2026 | Viewed by 788

Special Issue Editors


E-Mail Website
Guest Editor
1. Department of Nutrition and Food Science, Institute of Nutrition and Food Technology, Biomedical Research Centre, University of Granada, 18071 Granada, Spain
2. Instituto de Investigación Biosanitaria ibs.GRANADA, Universidad de Granada, 18071 Granada, Spain
Interests: antioxidant capacity; personalized nutrition; gut microbiota; chemical browning; diet
Special Issues, Collections and Topics in MDPI journals

E-Mail
Guest Editor
Department of Pharmacy, University of Naples Federico II, via Domenico Montesano 49, 80131 Naples, Italy
Interests: nutraceuticals; polyphenols; food chemistry; chromatography; mass spectrometry; food science
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy
Interests: nutrition; metabolic diseases; nutraceuticals; polyphenols; in vitro enzymatic assays; cell line culture
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor Assistant

Special Issue Information

Dear Colleagues,

Metabolic disorders—including diabetes, obesity, dyslipidemia, hypertension, and cardiovascular diseases—remain critical global health burdens; thus, the investigation of natural antioxidant compounds offers a promising perspective. These compounds, which are derived from food and vegetables sources, have demonstrated a range of biological effects, positioning themselves as potential therapeutic and preventive agents.

The first edition of this Special Issue, entitled “Natural Antioxidants and Metabolic Diseases” (https://www.mdpi.com/journal/antioxidants/special_issues/IG4O18I42Y), was a success, with 10 papers, both articles and reviews, published. Since then, this research field has experienced several advancements; thus, we cordially invite you to submit your valuable articles to the second edition of this Special Issue, underscoring these very relevant findings and progress. We seek to address key gaps in the literature, including the following topics:

  • Molecular mechanisms underlying antioxidant-mediated metabolic modulation;
  • Bioavailability and formulation challenges for clinical applications;
  • Preclinical and clinical evidence supporting efficacy and safety;
  • Synergistic effects of antioxidant combinations in complex metabolic networks.

We invite researchers in the fields of food chemistry, nutrition, biochemistry, pharmacology, and the medical sciences to submit original research articles, clinical reports, and review articles. Your participation and contributions are crucial to enriching the body of knowledge and gaining new insights into this field. With this Special Issue, we aim to provide a comprehensive and up-to-date overview of the advancements and potential of these compounds to support health and the management of metabolic diseases.

Prof. Dr. José Ángel Rufián-Henares
Dr. Fortuna Iannuzzo
Dr. Elisabetta Schiano
Guest Editors

Dr. Maria Maisto
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolic syndrome
  • antioxidant compounds
  • diabetes
  • obesity
  • cardiovascular diseases
  • biological effects
  • food sources
  • medicinal plants
  • oxidative stress
  • inflammation

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

13 pages, 457 KB  
Article
Effect of Guava Seeds on the Biochemical Parameters and Composition of HDL Subclasses in Ovariectomized Rats
by Lisette Monsibaez Ramírez-Melo, Elizabeth Carreón-Torres, Araceli Castañeda-Ovando, Eduardo Fernández-Martínez, Óscar Pérez-Méndez and Diego Estrada-Luna
Antioxidants 2025, 14(10), 1240; https://doi.org/10.3390/antiox14101240 - 15 Oct 2025
Viewed by 680
Abstract
Estrogen deficiency is associated with endothelial dysfunction, vascular inflammation, increased lipoprotein oxidation, accumulation of lipid-rich material, and platelet activation. The absence of estrogen causes physiological, metabolic, and biochemical changes that increase the risk of cardiometabolic disease development caused by a deregulation in metabolic [...] Read more.
Estrogen deficiency is associated with endothelial dysfunction, vascular inflammation, increased lipoprotein oxidation, accumulation of lipid-rich material, and platelet activation. The absence of estrogen causes physiological, metabolic, and biochemical changes that increase the risk of cardiometabolic disease development caused by a deregulation in metabolic processes such as lipid metabolism and plasma lipoprotein levels. High-density lipoprotein (HDL) has cardioprotective properties related to the quality and the quantity of its components that can be modified by some nutritional factors. Guava (Psidium guajava L.), a widely cultivated fruit in Mexico, is notable for its high polyunsaturated fatty acid and dietary fiber content in its seeds, but its effect on health is understudied. This study aimed to evaluate the effect of guava-seed supplementation on body weight, blood pressure, lipid profile, HDL composition, and paraoxonase-1 (PON1) activity in an ovariectomized rat model (OVX). Four groups with six adult female Wistar rats each were classified as a SHAM group: rats with simulated ovariectomy; OVX group: rats with ovariectomy; OVX + GS group: ovariectomized rats supplemented with 6 g of guava seeds; OVX + DGS group: ovariectomized rats supplemented with 6 g of defatted guava seeds. Biochemical parameters, size, and lipid concentration of HDL subclasses, apolipoproteins, and PON1 activity were determined. A decrease in body weight gain, systolic blood pressure, mean arterial pressure, and triglycerides in plasma was observed at the end of the experiment in the supplemented groups. The supplementation of 6 g of guava seeds for 30 days decreased biochemical parameters in ovariectomized rats; these results could be attributed to the seed composition, suggesting a protective effect against the risk of developing diseases in menopausal states. Full article
(This article belongs to the Special Issue Natural Antioxidants and Metabolic Diseases, 2nd Edition)
Show Figures

Figure 1

Back to TopTop