Antioxidant Response in Skeletal Muscle

Dear Colleagues,

The high oxygen consumption and metabolic rate of muscle fibers cause them to continuously generate reactive oxygen and nitrogen species (RONS) during rest, and their production is increased during muscle contraction. However, an imbalance between the antioxidant system and the generation of RONS triggers oxidative stress, which provokes damage to molecules and affects specific functions such as excitation–contraction coupling. Skeletal muscles are equipped with various enzymatic and non-enzymatic antioxidants, including superoxide dismutase, catalase, glutathione peroxidase, γ-glutamylcysteine synthetase and heme oxygenase-1. Accumulating evidence has shown that antioxidants can achieve optimal concentrations of RONS to perform physiological signal transduction in muscle. They function as biosensors of RONS and render skeletal muscle extremely flexible in both health and disease. As an example, RONS play a very important role in protein turnover, which can promote muscle hypertrophy and regeneration.

This Special Issue aims to provide a comprehensive overview of the skeletal-muscle-focused antioxidant responses accompanying both physiological (e.g., exercise) and pathological challenges. The latter involves muscle injury, metabolic diseases, muscle dystrophy, carcinogenesis, systemic inflammation, inactivity or immobilization, to only name a few disorders capable of altering redox balance. Authors are invited to submit their latest original and innovative research findings or review articles with new insights into the association between scavenging capacity and cell signaling, muscle function and muscle metabolism in the response to stressors. Both human and animal studies are welcome.

We look forward to receiving your contribution.

Dr. Jan Górski
Dr. Elzbieta Supruniuk
Guest Editors

Manuscript Submission Information

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• antioxidants
• skeletal muscle
• exercise
• muscle injury
• metabolic diseases
• muscle dystrophy
• cancer
• immobilization