Roles of Autophagy and Oxidative Stress in Cardiovascular Disease

Yun, Hyeong Rok; Singh, Manish Kumar; Han, Sunhee; Ranbhise, Jyotsna S.; Ha, Joohun; Kim, Sung Soo; Kang, Insug

doi:10.3390/antiox14101263

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Roles of Autophagy and Oxidative Stress in Cardiovascular Disease

by

Hyeong Rok Yun

^1,2,

Manish Kumar Singh

^1,2

,

Sunhee Han

^2,3,

Jyotsna S. Ranbhise

^2,3

,

Joohun Ha

^1,2,3,

Sung Soo Kim

^1,2,3,*

and

Insug Kang

^1,2,3,*

¹

Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea

²

Biomedical Science Institute, Kyung Hee University, Seoul 02447, Republic of Korea

³

Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea

^*

Authors to whom correspondence should be addressed.

Antioxidants 2025, 14(10), 1263; https://doi.org/10.3390/antiox14101263

Submission received: 16 September 2025 / Revised: 13 October 2025 / Accepted: 18 October 2025 / Published: 20 October 2025

(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Diseases and Vascular Pathophysiology)

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Abstract

Autophagy and oxidative stress influence cardiovascular pathology. Autophagy mediates lysosome-dependent clearance of damaged proteins and organelles and maintains mitochondrial quality control, proteostasis, and metabolic flexibility. Reactive oxygen species (ROS) originate from mitochondrial respiration and enzymatic reactions during stress. At physiological levels, ROS function as redox signals that activate degradation and recycling, whereas excess oxidants damage lipids, proteins, and nucleic acids and promote cell loss. This review integrates evidence across cardiovascular disease, including atherosclerosis, ischemia reperfusion injury, pressure overload remodeling, heart failure, diabetic cardiomyopathy, arrhythmia, aging, and inflammation.

Keywords: autophagy; oxidative stress; cardiovascular disease

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MDPI and ACS Style

Yun, H.R.; Singh, M.K.; Han, S.; Ranbhise, J.S.; Ha, J.; Kim, S.S.; Kang, I. Roles of Autophagy and Oxidative Stress in Cardiovascular Disease. Antioxidants 2025, 14, 1263. https://doi.org/10.3390/antiox14101263

AMA Style

Yun HR, Singh MK, Han S, Ranbhise JS, Ha J, Kim SS, Kang I. Roles of Autophagy and Oxidative Stress in Cardiovascular Disease. Antioxidants. 2025; 14(10):1263. https://doi.org/10.3390/antiox14101263

Chicago/Turabian Style

Yun, Hyeong Rok, Manish Kumar Singh, Sunhee Han, Jyotsna S. Ranbhise, Joohun Ha, Sung Soo Kim, and Insug Kang. 2025. "Roles of Autophagy and Oxidative Stress in Cardiovascular Disease" Antioxidants 14, no. 10: 1263. https://doi.org/10.3390/antiox14101263

APA Style

Yun, H. R., Singh, M. K., Han, S., Ranbhise, J. S., Ha, J., Kim, S. S., & Kang, I. (2025). Roles of Autophagy and Oxidative Stress in Cardiovascular Disease. Antioxidants, 14(10), 1263. https://doi.org/10.3390/antiox14101263

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Roles of Autophagy and Oxidative Stress in Cardiovascular Disease

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