Table of Contents
Pathogens, Volume 8, Issue 2 (June 2019)
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Cover Story (view full-size image) A model of the interactions between emerging periodontal bacteria with neutrophils in the gingival [...] Read more. A model of the interactions between emerging periodontal bacteria with neutrophils in the gingival tissue is presented. The putative periodontal pathogens Filifactor alocis and Peptoanaerobacter stomatis are both recognized by neutrophils through toll-like receptor 2/6 heterodimer. Neutrophils secrete inflammatory cytokines like TNF-α, lL-1β, and chemokines like CXCL1, CXCL8, CCL2, CCL3, and CCL4 upon infection with these periodontal pathogens. The secreted cytokines and chemokines enhance the chemotaxis of neutrophils and monocytes in the gingival tissue. Vashishta et al. described a differential release of cytokines and chemokines by neutrophils upon infection with the two perio-pathogens. The varying levels of cytokines and chemokines secretion help in steadily fueling the inflammation with the continuous recruitment of inflammatory cells and, thus, perpetuate this chronic inflammatory disease. View this paper