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Pathogens, Volume 8, Issue 2

2019 June - 46 articles

Cover Story: A model of the interactions between emerging periodontal bacteria with neutrophils in the gingival tissue is presented. The putative periodontal pathogens Filifactor alocis and Peptoanaerobacter stomatis are both recognized by neutrophils through toll-like receptor 2/6 heterodimer. Neutrophils secrete inflammatory cytokines like TNF-α, lL-1β, and chemokines like CXCL1, CXCL8, CCL2, CCL3, and CCL4 upon infection with these periodontal pathogens. The secreted cytokines and chemokines enhance the chemotaxis of neutrophils and monocytes in the gingival tissue. Vashishta et al. described a differential release of cytokines and chemokines by neutrophils upon infection with the two perio-pathogens. The varying levels of cytokines and chemokines secretion help in steadily fueling the inflammation with the continuous recruitment of inflammatory cells and, thus, perpetuate this chronic inflammatory disease. View this paper
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Articles (46)

  • Article
  • Open Access
31 Citations
5,330 Views
19 Pages

The study investigated the prevalence of potentially pathogenic and drug resistant Escherichia coli among drinking water sources in Jordan. A total of 109 confirmed E. coli isolates were analyzed. Antimicrobial susceptibility testing was done using t...

  • Review
  • Open Access
59 Citations
7,555 Views
30 Pages

Campylobacter at the Human–Food Interface: The African Perspective

  • Nikki Asuming-Bediako,
  • Angela Parry-Hanson Kunadu,
  • Sam Abraham and
  • Ihab Habib

The foodborne pathogen Campylobacter is a major cause of human gastroenteritis, accounting for an estimated annual 96 million cases worldwide. Assessment of the true burden of Campylobacter in the African context is handicapped by the under-reporting...

  • Article
  • Open Access
11 Citations
4,302 Views
14 Pages

Experimental Infection of Human Volunteers with the Heat-Stable Enterotoxin-Producing Enterotoxigenic Escherichia coli Strain TW11681

  • Sunniva Todnem Sakkestad,
  • Hans Steinsland,
  • Steinar Skrede,
  • Elisabeth Kleppa,
  • Kristine Lillebø,
  • Marianne Sævik,
  • Hanne Søyland,
  • Astrid Rykkje Heien,
  • Marit Gjerde Tellevik and
  • Kurt Hanevik
  • + 2 authors

Infection with enterotoxigenic Escherichia coli (ETEC) producing the heat-stable enterotoxin (ST) is one of the most important causes of childhood diarrhoea in low- and middle-income countries. Here, we undertook a controlled human infection model (C...

  • Article
  • Open Access
75 Citations
9,094 Views
11 Pages

The Antiviral Effect of Indonesian Medicinal Plant Extracts Against Dengue Virus In Vitro and In Silico

  • Rosmalena Rosmalena,
  • Berna Elya,
  • Beti E. Dewi,
  • Fithriyah Fithriyah,
  • Hidayati Desti,
  • Marissa Angelina,
  • Muhammad Hanafi,
  • Puspa D. Lotulung,
  • Vivitri D. Prasasty and
  • Dimas Seto

Dengue infections are still a worldwide burden, especially in Indonesia. There is no specific medication against the dengue virus. Recently, many types of research have been conducted to discover a new drug for dengue virus using natural resource ext...

  • Review
  • Open Access
18 Citations
4,432 Views
17 Pages

How Many Mammalian Reovirus Proteins are involved in the Control of the Interferon Response?

  • Delphine Lanoie,
  • Simon Boudreault,
  • Martin Bisaillon and
  • Guy Lemay

As with most viruses, mammalian reovirus can be recognized and attacked by the host-cell interferon response network. Similarly, many viruses have developed resistance mechanisms to counteract the host-cell response at different points of this respon...

  • Article
  • Open Access
20 Citations
6,870 Views
22 Pages

Host-Pathogen Interactions of Mycoplasma mycoides in Caprine and Bovine Precision-Cut Lung Slices (PCLS) Models

  • Yenehiwot Berhanu Weldearegay,
  • Sandy Müller,
  • Jana Hänske,
  • Anja Schulze,
  • Aline Kostka,
  • Nancy Rüger,
  • Marion Hewicker-Trautwein,
  • Ralph Brehm,
  • Peter Valentin-Weigand and
  • Jochen Meens
  • + 2 authors

Respiratory infections caused by mycoplasma species in ruminants lead to considerable economic losses. Two important ruminant pathogens are Mycoplasma mycoides subsp. Mycoides (Mmm), the aetiological agent of contagious bovine pleuropneumonia and Myc...

  • Article
  • Open Access
21 Citations
5,529 Views
13 Pages

Detection of Pathogenic Viruses, Pathogen Indicators, and Fecal-Source Markers within Tanker Water and Their Sources in the Kathmandu Valley, Nepal

  • Bikash Malla,
  • Rajani Ghaju Shrestha,
  • Sarmila Tandukar,
  • Dinesh Bhandari,
  • Ocean Thakali,
  • Jeevan B. Sherchand and
  • Eiji Haramoto

Tanker water is used extensively for drinking as well as domestic purposes in the Kathmandu Valley of Nepal. This study aimed to investigate water quality in terms of microbial contamination and determine sources of fecal pollution within these water...

  • Article
  • Open Access
12 Citations
5,011 Views
18 Pages

The rate of change in selective pressures is one of the main factors that determines the likelihood that populations can adapt to stress conditions. Generally, the reduction in the population size that accompanies abrupt environmental changes makes i...

  • Article
  • Open Access
41 Citations
8,877 Views
21 Pages

Staphylococcus aureus is one of the most important pathogens of humans and animals. Livestock production contributes a significant proportion to the South African Gross Domestic Product. Consequently, the aim of this study was to determine for the fi...

  • Review
  • Open Access
48 Citations
11,658 Views
16 Pages

The Mosquito Immune System and the Life of Dengue Virus: What We Know and Do Not Know

  • Debica Mukherjee,
  • Sandeepan Das,
  • Feroza Begum,
  • Sweety Mal and
  • Upasana Ray

Flaviviruses are largely transmitted to humans by their arthropod vectors such as mosquitoes or ticks. The dengue virus (DENV) is one of the members of the family Flaviviridae and is the causative agent of dengue fever. In the mosquito vector, DENV e...

  • Review
  • Open Access
118 Citations
15,667 Views
25 Pages

Biocontrol of Cereal Crop Diseases Using Streptomycetes

  • Jake T. Newitt,
  • Samuel M. M. Prudence,
  • Matthew I. Hutchings and
  • Sarah F. Worsley

A growing world population and an increasing demand for greater food production requires that crop losses caused by pests and diseases are dramatically reduced. Concurrently, sustainability targets mean that alternatives to chemical pesticides are be...

  • Review
  • Open Access
19 Citations
5,109 Views
15 Pages

Cattle infected with Babesia bovis face a bifurcated fate: Either die of the severe acute infection, or survive and carry for many years a highly persistent but generally asymptomatic infection. In this review, the author describes known and potentia...

  • Article
  • Open Access
7 Citations
6,097 Views
10 Pages

Severe Clinical Outcomes of Tuberculosis in Kharkiv Region, Ukraine, Are Associated with Beijing Strains of Mycobacterium tuberculosis

  • Olha Konstantynovska,
  • Mariia Rekrotchuk,
  • Ivan Hrek,
  • Anton Rohozhyn,
  • Nataliia Rudova,
  • Petro Poteiko,
  • Anton Gerilovych,
  • Eric Bortz and
  • Oleksii Solodiankin

Genotypic variation in Beijing lineages of Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis (TB), has been associated with hyper virulence and the spread of extensively and multiple drug (X/MDR) resistant MTB strains in Eastern E...

  • Article
  • Open Access
8 Citations
4,565 Views
17 Pages

Mucosa-associated Escherichia coli are increased in Crohn’s disease (CD) and colorectal cancer (CRC). CD isolates replicate within macrophages but the specificity of this effect for CD and its mechanism are unclear. Gentamicin exclusion assay w...

  • Article
  • Open Access
1 Citations
7,533 Views
24 Pages

It has now been a century that drug resistance has been getting worse in human infectious diseases medicine. A similar trend is observed in veterinary medicine and agriculture. The successful control of drug resistance requires an understanding of bi...

  • Article
  • Open Access
2 Citations
5,983 Views
13 Pages

The current classification of animal viruses is largely based on the virus molecular world. Less attention is given to why and how virus fitness results from the success of virus transmission. Virus transmission reflects the infection-shedding-transm...

  • Review
  • Open Access
65 Citations
11,053 Views
15 Pages

A Contemporary View of Respiratory Syncytial Virus (RSV) Biology and Strain-Specific Differences

  • Mansi C. Pandya,
  • Sean M. Callahan,
  • Kyryll G. Savchenko and
  • Christopher C. Stobart

Respiratory syncytial virus (RSV) is a human respiratory pathogen which remains a leading viral cause of hospitalizations and mortality among infants in their first year of life. Here, we review the biology of RSV, the primary laboratory isolates or...

  • Article
  • Open Access
9 Citations
5,550 Views
10 Pages

Demographics and Epidemiology of Hepatitis B in the State of Qatar: A Five-Year Surveillance-Based Incidence Study

  • Hamad E. Al Romaihi,
  • Nandakumar Ganesan,
  • Elmoubasher A. Farag,
  • Maria K. Smatti,
  • Gheyath K. Nasrallah,
  • Sayed M. Himatt,
  • Moutaz F. Derbala,
  • Maha Alshamali,
  • Lylu K. Mahadoon and
  • Hadi M. Yassine
  • + 5 authors

Background: Expatriates represent >80% of Qatar’s population, mostly arriving from countries in Africa and Asia that are endemic with many diseases. This increases the risk for introducing new pathogens into the country and provides a platfo...

  • Article
  • Open Access
11 Citations
4,700 Views
13 Pages

Infections with Carbapenem-Resistant Gram-Negative Bacteria are a Serious Problem Among Critically Ill Children: A Single-Centre Retrospective Study

  • Fatih Aygun,
  • Fatma Deniz Aygun,
  • Fatih Varol,
  • Cansu Durak,
  • Haluk Çokuğraş,
  • Yıldız Camcıoğlu and
  • Halit Çam

Children in paediatric intensive care units (PICUs) are vulnerable to infections because invasive devices are frequently used during their admission. We aimed to determine the prevalence, associated factors, and prognosis of infections in our PICU. T...

  • Review
  • Open Access
177 Citations
23,178 Views
41 Pages

Fungal-Bacterial Interactions in Health and Disease

  • Wibke Krüger,
  • Sarah Vielreicher,
  • Mario Kapitan,
  • Ilse D. Jacobsen and
  • Maria Joanna Niemiec

Fungi and bacteria encounter each other in various niches of the human body. There, they interact directly with one another or indirectly via the host response. In both cases, interactions can affect host health and disease. In the present review, we...

  • Article
  • Open Access
76 Citations
8,359 Views
20 Pages

Lactobacillus plantarum are amongst the diversified lactic acid bacteria (LAB) species which are being utilized abundantly in the food industry. Numerous L. plantarum strains have been reported to produce several antimicrobial compounds. Diacetyl, hy...

  • Article
  • Open Access
6 Citations
5,026 Views
8 Pages

Occurrence of Bovine Cysticercosis in Two Regions of the State of Tocantins-Brazil and the Importance of Pathogen Identification

  • Benta Natânia Silva FIGUEIREDO,
  • Ricardo Alencar LIBóRIO,
  • Megumi SATO,
  • Camila Figueira da SILVA,
  • Ronaldo Alves PEREIRA-JUNIOR,
  • Yuichi CHIGUSA,
  • Satoru KAWAI and
  • Marcello Otake SATO

Bovine cysticercosis, caused by Taenia saginata metacestodes, is the cause of significant economic losses to the meat production chain by condemnation and downgrading of infected carcasses. It is also a public health issue causing human taeniasis. Th...

  • Article
  • Open Access
7 Citations
5,088 Views
19 Pages

Differential Helicobacter pylori Plasticity in the Gastric Niche of Subjects at Increased Gastric Cancer Risk

  • Mariateresa Casarotto,
  • Chiara Pratesi,
  • Ettore Bidoli,
  • Stefania Maiero,
  • Raffaella Magris,
  • Agostino Steffan,
  • Giancarlo Basaglia,
  • Vincenzo Canzonieri,
  • Valli De Re and
  • Stefania Zanussi
  • + 1 author

Helicobacter pylori (H. pylori) represents an independent risk factor for Gastric Cancer (GC). First Degree Relatives (FDR) of GC subjects and Autoimmune Gastritis (AG) patients are both at increased risk for GC. H. pylori genetic heterogeneity withi...

  • Article
  • Open Access
9 Citations
6,460 Views
12 Pages

Piper betel Compounds Piperidine, Eugenyl Acetate, and Chlorogenic Acid Are Broad-Spectrum Anti-Vibrio Compounds that Are Also Effective on MDR Strains of the Pathogen

  • Erika Acosta-Smith,
  • Nidia Leon-Sicairos,
  • Sandeep Tiwari,
  • Hector Flores-Villaseñor,
  • Adrian Canizalez-Roman,
  • Ranjith Kumavath,
  • Preetam Ghosh,
  • Vasco Azevedo and
  • Debmalya Barh

The natural population of the aquatic environment supports a diverse aquatic biota and a robust seafood industry. However, this environment also provides an appropriate niche for the growth of pathogenic bacteria that cause problems for human health....

  • Review
  • Open Access
36 Citations
29,162 Views
22 Pages

Hepatitis B Virus Molecular Epidemiology, Host-Virus Interaction, Coinfection, and Laboratory Diagnosis in the MENA Region: An Update

  • Duaa W. Al-Sadeq,
  • Sara A. Taleb,
  • Roan E. Zaied,
  • Sara M. Fahad,
  • Maria K. Smatti,
  • Balsam R. Rizeq,
  • Asmaa A. Al Thani,
  • Hadi M. Yassine and
  • Gheyath K. Nasrallah

Hepatitis B virus (HBV) is an enveloped partial double-stranded DNA virus that can cause acute and chronic hepatitis. According to the World Health Organization (WHO) and the Centers for Disease Control and Prevention (CDC), 257 million people are li...

  • Article
  • Open Access
6 Citations
4,689 Views
13 Pages

Whole Genome Sequencing of the First H3N8 Equine Influenza Virus Identified in Malaysia

  • Jacinta Gahan,
  • Marie Garvey,
  • Rozanah Asmah Abd Samad and
  • Ann Cullinane

In August 2015, Malaysia experienced an outbreak of acute respiratory disease in racehorses. Clinical signs observed were consistent with equine influenza (EI) infection. The index cases were horses recently imported from New Zealand. Rapid control m...

  • Article
  • Open Access
25 Citations
5,601 Views
18 Pages

This study was performed to investigate the mechanism of action of ursolic acid in terms of anti-Toxoplasma gondii effects, including immunomodulatory effects. We evaluated the anti-T. gondii effects of ursolic acid, and analyzed the production of ni...

  • Review
  • Open Access
14 Citations
5,625 Views
21 Pages

Diarrhoeal disease is still one of the most challenging issues for health in many countries across the Eastern Mediterranean region (EMR), with infectious diarrhoea being an important cause of morbidity and mortality, especially in children under fiv...

  • Article
  • Open Access
31 Citations
5,640 Views
13 Pages

Putative Periodontal Pathogens, Filifactor alocis and Peptoanaerobacter stomatis, Induce Differential Cytokine and Chemokine Production by Human Neutrophils

  • Aruna Vashishta,
  • Emeri Jimenez-Flores,
  • Christopher K. Klaes,
  • Shifu Tian,
  • Irina Miralda,
  • Richard J. Lamont and
  • Silvia M. Uriarte

Periodontitis is a highly prevalent infectious disease that affects ~ 50% of the adults in the USA alone. Two Gram-positive anaerobic oral bacteria, Filifactor alocis and Peptoanaerobacter stomatis, have emerged as important periodontal pathogens. Ne...

  • Communication
  • Open Access
18 Citations
4,427 Views
6 Pages

Serological and Molecular Investigation on Toxoplasma gondii Infection in Wild Birds

  • Simona Nardoni,
  • Guido Rocchigiani,
  • Ilaria Varvaro,
  • Iolanda Altomonte,
  • Renato Ceccherelli and
  • Francesca Mancianti

Toxoplasma gondii is an obligate apicomplexan zoonotic parasite that infects humans and other animals and is responsible for toxoplasmosis. This parasite causes one of the most common parasitic infections in humans worldwide. Toxoplasmosis meets the...

  • Article
  • Open Access
14 Citations
5,307 Views
12 Pages

Identification and Characterization of a Novel Robigovirus Species from Sweet Cherry in Turkey

  • Kadriye Çağlayan,
  • Vahid Roumi,
  • Mona Gazel,
  • Eminur Elçi,
  • Mehtap Acioğlu,
  • Irena Mavric Plesko,
  • Jean-Sebastien Reynard,
  • Francois Maclot and
  • Sebastien Massart

High throughput sequencing of total RNA isolated from symptomatic leaves of a sweet cherry tree (Prunus avium cv. 0900 Ziraat) from Turkey identified a new member of the genus Robigovirus designated cherry virus Turkey (CVTR). The presence of the vir...

  • Review
  • Open Access
17 Citations
8,025 Views
13 Pages

A Review on Viruses Infecting Taro (Colocasia esculenta (L.) Schott)

  • Mohd Shakir Mohamad Yusop,
  • Mohd Faiz Mat Saad,
  • Noraini Talip,
  • Syarul Nataqain Baharum and
  • Hamidun Bunawan

Taro is an important crop in parts of the world, especially in the Pacific Islands. Like all plants, it is also susceptible to virus infections that could result in diseases, which negatively affects the source of food and trade revenue. Understandin...

  • Article
  • Open Access
38 Citations
8,406 Views
13 Pages

Inhibition of Pseudomonas aeruginosa Biofilm Formation with Surface Modified Polymeric Nanoparticles

  • Tyler R. Flockton,
  • Logan Schnorbus,
  • Agustin Araujo,
  • Jill Adams,
  • Maryjane Hammel and
  • Lark J. Perez

The gram-negative bacterial pathogen Pseudomonas aeruginosa represents a prominent clinical concern. Due to the observed high levels of antibiotic resistance, copious biofilm formation, and wide array of virulence factors produced by these bacteria,...

  • Review
  • Open Access
81 Citations
22,377 Views
23 Pages

Candida albicans Interactions with Mucosal Surfaces during Health and Disease

  • Spyridoula-Angeliki Nikou,
  • Nessim Kichik,
  • Rhys Brown,
  • Nicole O. Ponde,
  • Jemima Ho,
  • Julian R. Naglik and
  • Jonathan P. Richardson

Flexible adaptation to the host environment is a critical trait that underpins the success of numerous microbes. The polymorphic fungus Candida albicans has evolved to persist in the numerous challenging niches of the human body. The interaction of C...

  • Review
  • Open Access
76 Citations
7,334 Views
11 Pages

Interleukin-17 in Antifungal Immunity

  • Florian Sparber and
  • Salomé LeibundGut-Landmann

The field of IL-17 biology has received much attention over the last decade owing to the pathogenic role of this cytokine in psoriasis and other autoinflammatory disorders and the successful implementation of IL-17-targeting therapies in patients suf...

  • Review
  • Open Access
29 Citations
7,208 Views
10 Pages

The Contribution of Host Cells to Pneumocystis Immunity: An Update

  • Patricia Otieno-Odhiambo,
  • Sean Wasserman and
  • J. Claire Hoving

Pneumocystis is a ubiquitous atypical fungus that is distributed globally. The genus comprises morphologically similar but genetically heterogeneous species that have co-evolved with specific mammalian hosts as obligate intra-pulmonary pathogens. In...

  • Article
  • Open Access
5 Citations
5,025 Views
9 Pages

A Retrospective Epidemiological Study of the Incidence and Risk Factors of Salmonellosis in Bahrain in Children during 2012–2016

  • Simone Perna,
  • Zahraa Alaali,
  • Tariq A. Alalwan,
  • Essam Moahmmed Janahi,
  • Sakina Mustafa,
  • Mariangela Rondanelli and
  • Ali Salman Bin Thani

Salmonellosis is one of the major public health concerns in Bahrain as it has increased rapidly during the past few years. This study aims to determine the prevalence of salmonellosis in children and the possible risk factors such as age, geographica...

  • Review
  • Open Access
64 Citations
13,505 Views
29 Pages

Zoonoses present a major public health threat and are estimated to account for a substantial part of the infectious disease burden in low-income countries. The severity of zoonotic diseases is compounded by factors such as poverty, living in close co...

  • Article
  • Open Access
22 Citations
5,098 Views
16 Pages

Macrocolony of NDM-1 Producing Enterobacter hormaechei subsp. oharae Generates Subpopulations with Different Features Regarding the Response of Antimicrobial Agents and Biofilm Formation

  • Flávia Roberta Brust,
  • Luana Boff,
  • Danielle da Silva Trentin,
  • Franciele Pedrotti Rozales,
  • Afonso Luís Barth and
  • Alexandre José Macedo

Enterobacter cloacae complex has been increasingly recognized as a nosocomial pathogen representing the third major Enterobacteriaceae species involved with infections. This study aims to evaluate virulence and antimicrobial susceptibility of subpopu...

  • Article
  • Open Access
9 Citations
4,718 Views
8 Pages

Persistent Infection with Chicken Anemia Virus in 3-Week-Old Chickens Induced by Inoculation of the Virus by the Natural Route

  • Suttitas Tongkamsai,
  • Meng-Shiou Lee,
  • Ming-Chu Cheng,
  • Hso-Chi Chaung,
  • Yi-Lun Tsai and
  • Yi-Yang Lien

Naturally acquired chicken anemia virus (CAV) infection in chickens frequently occurs from 3 weeks of age onward after maternally derived antibodies have decayed. The oral inoculation of older chickens with CAV was reported to have negative effects o...

  • Review
  • Open Access
92 Citations
12,221 Views
24 Pages

ApiAP2 Transcription Factors in Apicomplexan Parasites

  • Myriam D. Jeninga,
  • Jennifer E. Quinn and
  • Michaela Petter

Apicomplexan parasites are protozoan organisms that are characterised by complex life cycles and they include medically important species, such as the malaria parasite Plasmodium and the causative agents of toxoplasmosis (Toxoplasma gondii) and crypt...

  • Review
  • Open Access
49 Citations
8,545 Views
11 Pages

Life expectancy in the West is the highest it has ever been, due to the introduction of better hygiene practices and sophisticated medical interventions for cancer, autoimmunity and infectious disease. With these modern advances, a rise in the preval...

  • Article
  • Open Access
16 Citations
5,061 Views
12 Pages

Genetic Diversity of Salmonella Derby from the Poultry Sector in Europe

  • Yann Sévellec,
  • Arnaud Felten,
  • Nicolas Radomski,
  • Sophie A. Granier,
  • Simon Le Hello,
  • Liljana Petrovska,
  • Michel-Yves Mistou and
  • Sabrina Cadel-Six

Salmonella Derby (S. Derby) is emerging in Europe as a predominant serovar in fattening turkey flocks. This serovar was recorded as being predominant in the turkey sector in 2014 in the United Kingdom (UK). Only two years later, in 2016, it was also...

  • Article
  • Open Access
108 Citations
13,129 Views
14 Pages

Prevalence of Helicobacter pylori and Its Associated Factors among Healthy Asymptomatic Residents in the United Arab Emirates

  • Ghalia Khoder,
  • Jibran Sualeh Muhammad,
  • Ibrahim Mahmoud,
  • Sameh S. M. Soliman and
  • Christophe Burucoa

The United Arab Emirates (UAE) has been under continuous populational influences from Asia, Europe, and Africa, making it an ideal site for epidemiological studies on Helicobacter pylori. However, there has been a paucity of well-designed prevalence...

  • Article
  • Open Access
26 Citations
7,703 Views
8 Pages

Philippine banana is currently threatened by Fusarium oxysporum f. sp. cubense Tropical Race 4 (FocR4). This study investigated the use of Trichoderma harzianum pre-treated with Glomus spp, as a means of managing Fusarium wilt on young ‘Lakatan’ bana...

  • Article
  • Open Access
68 Citations
12,633 Views
16 Pages

Epidemiology of Tick-Borne Encephalitis (TBE) in Germany, 2001–2018

  • Wiebke Hellenbrand,
  • Teresa Kreusch,
  • Merle M. Böhmer,
  • Christiane Wagner-Wiening,
  • Gerhard Dobler,
  • Ole Wichmann and
  • Doris Altmann

We reviewed tick-borne encephalitis (TBE) surveillance and epidemiology in Germany, as these underlie public health recommendations, foremost vaccination. We performed descriptive analyses of notification data (2001–2018, n = 6063) according to regio...

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Pathogens - ISSN 2076-0817