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Review

The Contribution of Host Cells to Pneumocystis Immunity: An Update

1
AFGrica Medical Mycology Research Unit, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town 7925, South Africa
2
Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, UK
3
Division of Immunology, Department of Pathology, University of Cape Town, Cape Town 7925, South Africa
4
Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town 7925, South Africa
5
Division of Infectious Diseases and HIV Medicine, Department of Medicine, University of Cape Town, Cape Town 7925, South Africa
*
Author to whom correspondence should be addressed.
Pathogens 2019, 8(2), 52; https://doi.org/10.3390/pathogens8020052
Received: 12 March 2019 / Revised: 15 April 2019 / Accepted: 16 April 2019 / Published: 19 April 2019
(This article belongs to the Special Issue Immunology of Fungal Infections)
Pneumocystis is a ubiquitous atypical fungus that is distributed globally. The genus comprises morphologically similar but genetically heterogeneous species that have co-evolved with specific mammalian hosts as obligate intra-pulmonary pathogens. In humans, Pneumocystis jirovecii is the causative organism of Pneumocystis pneumonia (PCP) in immunocompromised individuals, a serious illness frequently leading to life-threatening respiratory failure. Initially observed in acquired immunodeficiency syndrome (AIDS) patients, PCP is increasingly observed in immunocompromised non-AIDS patients. The evolving epidemiology and persistently poor outcomes of this common infection will require new strategies for diagnosis and treatment. A deeper understanding of host immune responses and of the cells that mediate them will improve the chance of developing new treatment strategies. This brief review provides an update on recent studies on the role of host immunity against Pneumocystis. View Full-Text
Keywords: Pneumocystis; Pneumocystis life forms; alveolar macrophages; dendritic cells; lymphocytes Pneumocystis; Pneumocystis life forms; alveolar macrophages; dendritic cells; lymphocytes
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MDPI and ACS Style

Otieno-Odhiambo, P.; Wasserman, S.; Hoving, J.C. The Contribution of Host Cells to Pneumocystis Immunity: An Update. Pathogens 2019, 8, 52. https://doi.org/10.3390/pathogens8020052

AMA Style

Otieno-Odhiambo P, Wasserman S, Hoving JC. The Contribution of Host Cells to Pneumocystis Immunity: An Update. Pathogens. 2019; 8(2):52. https://doi.org/10.3390/pathogens8020052

Chicago/Turabian Style

Otieno-Odhiambo, Patricia; Wasserman, Sean; Hoving, J. C. 2019. "The Contribution of Host Cells to Pneumocystis Immunity: An Update" Pathogens 8, no. 2: 52. https://doi.org/10.3390/pathogens8020052

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