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Genetic Diversity of Salmonella Derby from the Poultry Sector in Europe

1
Laboratory for Food Safety, Université PARIS-EST, ANSES, F-94701 Maisons-Alfort, France
2
Institut Pasteur, Centre National de Référence des Salmonella, Unité des Bactéries Pathogènes Entériques, 75015 Paris, France
3
Animal and Plant Health Agency, Addlestone KT15 3NB, Surrey, UK
*
Author to whom correspondence should be addressed.
Current affiliation: ANSES, Fougères Laboratory, F-35306 Fougères, France (S.A.G.); Université de Normandie, EA 2656 GRAM 2.0, UNICAEN, 14033 Caen, France (S.L.H.).
Pathogens 2019, 8(2), 46; https://doi.org/10.3390/pathogens8020046
Received: 5 February 2019 / Revised: 15 March 2019 / Accepted: 22 March 2019 / Published: 4 April 2019
(This article belongs to the Section Waterborne/Foodborne/Airborne Pathogens)
Salmonella Derby (S. Derby) is emerging in Europe as a predominant serovar in fattening turkey flocks. This serovar was recorded as being predominant in the turkey sector in 2014 in the United Kingdom (UK). Only two years later, in 2016, it was also recorded in the turkey and broiler sectors in Ireland and Spain. These S. Derby isolates were characterised as members of the multilocus sequence type (MLST) profile 71 (ST71). For the first time, we characterise by whole genome sequencing (WGS) analysis a panel of 90 S. Derby ST71 genomes to understand the routes of transmission of this emerging pathogen within the poultry/turkey food trade. Selected panel included strains isolated as early as 2010 in five leading European g countries for turkey meat production. Twenty-one of the 90 genomes were extracted from a public database—Enterobase. Five of these originated from the United States (n = 3), China (n = 1) and Taiwan (n = 1) isolated between 1986 and 2016. A phylogenomic analysis at the core-genome level revealed the presence of three groups. The largest group contained 97.5% of the European strains and included both, turkey and human isolates that were genetically related by an average of 35 ± 15 single nucleotide polymorphism substitutions (SNPs). To illustrate the diversity, the presence of antimicrobial resistance genes and phages were characteised in 30, S. Derby ST71 genomes, including 11 belonging to this study This study revealed an emergent turkey-related S. Derby ST71 clone circulating in at least five European countries (the UK, Germany, Poland, Italy, and France) since 2010 that causes human gastroenteritis. A matter of concern is the identification of a gyrA mutation involved in resistance to quinolone, present in the Italian genomes. Interestingly, the diversity of phages seems to be related to the geographic origins. These results constitute a baseline for following the spread of this emerging pathogen and identifying appropriate monitoring and prevention measures. View Full-Text
Keywords: Salmonella Derby; reference genome ST71; poultry sector; human infection; phylogenetic analysis; antimicrobial resistance; phage analysis Salmonella Derby; reference genome ST71; poultry sector; human infection; phylogenetic analysis; antimicrobial resistance; phage analysis
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MDPI and ACS Style

Sévellec, Y.; Felten, A.; Radomski, N.; Granier, S.A.; Le Hello, S.; Petrovska, L.; Mistou, M.-Y.; Cadel-Six, S. Genetic Diversity of Salmonella Derby from the Poultry Sector in Europe. Pathogens 2019, 8, 46. https://doi.org/10.3390/pathogens8020046

AMA Style

Sévellec Y, Felten A, Radomski N, Granier SA, Le Hello S, Petrovska L, Mistou M-Y, Cadel-Six S. Genetic Diversity of Salmonella Derby from the Poultry Sector in Europe. Pathogens. 2019; 8(2):46. https://doi.org/10.3390/pathogens8020046

Chicago/Turabian Style

Sévellec, Yann; Felten, Arnaud; Radomski, Nicolas; Granier, Sophie A.; Le Hello, Simon; Petrovska, Liljana; Mistou, Michel-Yves; Cadel-Six, Sabrina. 2019. "Genetic Diversity of Salmonella Derby from the Poultry Sector in Europe" Pathogens 8, no. 2: 46. https://doi.org/10.3390/pathogens8020046

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