Next Article in Journal
Fungal-Bacterial Interactions in Health and Disease
Previous Article in Journal
Demographics and Epidemiology of Hepatitis B in the State of Qatar: A Five-Year Surveillance-Based Incidence Study
 
 
Article

Infections with Carbapenem-Resistant Gram-Negative Bacteria are a Serious Problem Among Critically Ill Children: A Single-Centre Retrospective Study

1
Department of Pediatric Intensive Care Unit, Istanbul University Cerrahpasa Medical Faculty, Fatih, Istanbul 34098, Turkey
2
Department of Infectious Disease, Istanbul University Cerrahpasa Medical Faculty, Fatih, Istanbul 34098, Turkey
*
Author to whom correspondence should be addressed.
Pathogens 2019, 8(2), 69; https://doi.org/10.3390/pathogens8020069
Received: 23 April 2019 / Revised: 16 May 2019 / Accepted: 20 May 2019 / Published: 21 May 2019
(This article belongs to the Section Human Pathogens)
Children in paediatric intensive care units (PICUs) are vulnerable to infections because invasive devices are frequently used during their admission. We aimed to determine the prevalence, associated factors, and prognosis of infections in our PICU. This retrospective study evaluated culture results from 477 paediatric patients who were treated in the PICU between January 2014 and March 2019. Ninety patients (18.9%) had bacterial infections, with gram-negative bacteria being the predominant infectious agents. Culture-positive patients were younger than culture-negative patients, and age was related to mortality and various clinical factors. Culture-positive bacterial infections in the PICU were associated with increased use of invasive mechanical ventilation (odds ratio(OR); 2.254), red blood cell (RBC) transfusions (OR:2.624), and inotropic drugs (OR:2.262). Carbapenem resistance was found in approximately one-third of gram-negative bacteria, and was most common in tracheal aspirate specimens and cases involving Klebsiella spp. Total parenteral nutrition was a significant risk factor (OR:5.870). Positive blood culture results were associated with poorer patient survival than other culture results. These findings indicate that infections, especially those involving carbapenem-resistant bacteria, are an important issue when treating critically ill children. View Full-Text
Keywords: carbapenem resistance; paediatric patients; nosocomial infection; colistin; tigecycline carbapenem resistance; paediatric patients; nosocomial infection; colistin; tigecycline
Show Figures

Figure 1

MDPI and ACS Style

Aygun, F.; Aygun, F.D.; Varol, F.; Durak, C.; Çokuğraş, H.; Camcıoğlu, Y.; Çam, H. Infections with Carbapenem-Resistant Gram-Negative Bacteria are a Serious Problem Among Critically Ill Children: A Single-Centre Retrospective Study. Pathogens 2019, 8, 69. https://doi.org/10.3390/pathogens8020069

AMA Style

Aygun F, Aygun FD, Varol F, Durak C, Çokuğraş H, Camcıoğlu Y, Çam H. Infections with Carbapenem-Resistant Gram-Negative Bacteria are a Serious Problem Among Critically Ill Children: A Single-Centre Retrospective Study. Pathogens. 2019; 8(2):69. https://doi.org/10.3390/pathogens8020069

Chicago/Turabian Style

Aygun, Fatih, Fatma Deniz Aygun, Fatih Varol, Cansu Durak, Haluk Çokuğraş, Yıldız Camcıoğlu, and Halit Çam. 2019. "Infections with Carbapenem-Resistant Gram-Negative Bacteria are a Serious Problem Among Critically Ill Children: A Single-Centre Retrospective Study" Pathogens 8, no. 2: 69. https://doi.org/10.3390/pathogens8020069

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop