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ApiAP2 Transcription Factors in Apicomplexan Parasites

1
Mikrobiologisches Institut—Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, 91054 Erlangen, Germany
2
Department of Medicine, The University of Melbourne, Melbourne, VIC 3010, Australia
*
Author to whom correspondence should be addressed.
Pathogens 2019, 8(2), 47; https://doi.org/10.3390/pathogens8020047
Received: 28 February 2019 / Revised: 26 March 2019 / Accepted: 28 March 2019 / Published: 7 April 2019
(This article belongs to the Section Human Pathogens)
Apicomplexan parasites are protozoan organisms that are characterised by complex life cycles and they include medically important species, such as the malaria parasite Plasmodium and the causative agents of toxoplasmosis (Toxoplasma gondii) and cryptosporidiosis (Cryptosporidium spp.). Apicomplexan parasites can infect one or more hosts, in which they differentiate into several morphologically and metabolically distinct life cycle stages. These developmental transitions rely on changes in gene expression. In the last few years, the important roles of different members of the ApiAP2 transcription factor family in regulating life cycle transitions and other aspects of parasite biology have become apparent. Here, we review recent progress in our understanding of the different members of the ApiAP2 transcription factor family in apicomplexan parasites. View Full-Text
Keywords: Apicomplexa; Plasmodium; Toxoplasma; Cryptosporidium; malaria; gene regulation; transcription factor; ApiAP2; differentiation Apicomplexa; Plasmodium; Toxoplasma; Cryptosporidium; malaria; gene regulation; transcription factor; ApiAP2; differentiation
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MDPI and ACS Style

Jeninga, M.D.; Quinn, J.E.; Petter, M. ApiAP2 Transcription Factors in Apicomplexan Parasites. Pathogens 2019, 8, 47.

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