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Interleukin-17 in Antifungal Immunity

Section of Immunology, Vetsuisse Faculty, University of Zürich, Winterthurerstrasse 266a, CH-8057 Zürich, Switzerland
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Pathogens 2019, 8(2), 54; https://doi.org/10.3390/pathogens8020054
Received: 29 March 2019 / Revised: 17 April 2019 / Accepted: 17 April 2019 / Published: 22 April 2019
(This article belongs to the Special Issue Immunology of Fungal Infections)
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Abstract

The field of IL-17 biology has received much attention over the last decade owing to the pathogenic role of this cytokine in psoriasis and other autoinflammatory disorders and the successful implementation of IL-17-targeting therapies in patients suffering from these diseases. IL-17-mediated pathologies are contrasted by the important host beneficial effects of this cytokine. IL-17 is essential for regulating microbial colonization in barrier tissues. Rare congenital defects in the IL-17 pathway exemplify the relevance of IL-17 in protective immunity against the opportunistic fungal pathogen C. albicans. However, more recently, evidence is accumulating that IL-17 can also provide protection against fungi other than C. albicans. Importantly, protective IL-17 responses directed against commensal fungi can, under certain conditions, promote inflammation with detrimental consequences for the host, thereby assigning fungi a new role as disease-promoting factors apart from their role as potential infectious agents. View Full-Text
Keywords: Interleukin-17; fungal pathogens; fungal commensals; C. albicans; host protection; immunopathology Interleukin-17; fungal pathogens; fungal commensals; C. albicans; host protection; immunopathology
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Sparber, F.; LeibundGut-Landmann, S. Interleukin-17 in Antifungal Immunity. Pathogens 2019, 8, 54.

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