Interleukin-17 in Antifungal Immunity
AbstractThe field of IL-17 biology has received much attention over the last decade owing to the pathogenic role of this cytokine in psoriasis and other autoinflammatory disorders and the successful implementation of IL-17-targeting therapies in patients suffering from these diseases. IL-17-mediated pathologies are contrasted by the important host beneficial effects of this cytokine. IL-17 is essential for regulating microbial colonization in barrier tissues. Rare congenital defects in the IL-17 pathway exemplify the relevance of IL-17 in protective immunity against the opportunistic fungal pathogen C. albicans. However, more recently, evidence is accumulating that IL-17 can also provide protection against fungi other than C. albicans. Importantly, protective IL-17 responses directed against commensal fungi can, under certain conditions, promote inflammation with detrimental consequences for the host, thereby assigning fungi a new role as disease-promoting factors apart from their role as potential infectious agents. View Full-Text
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Sparber, F.; LeibundGut-Landmann, S. Interleukin-17 in Antifungal Immunity. Pathogens 2019, 8, 54.
Sparber F, LeibundGut-Landmann S. Interleukin-17 in Antifungal Immunity. Pathogens. 2019; 8(2):54.Chicago/Turabian Style
Sparber, Florian; LeibundGut-Landmann, Salomé. 2019. "Interleukin-17 in Antifungal Immunity." Pathogens 8, no. 2: 54.
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