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Candida albicans Interactions with Mucosal Surfaces during Health and Disease

1
Protein Phosphorylation Laboratory, The Francis Crick Institute, London NW1 1AT, UK
2
Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King’s College London, London SE1 1UL, UK
*
Author to whom correspondence should be addressed.
Pathogens 2019, 8(2), 53; https://doi.org/10.3390/pathogens8020053
Received: 28 February 2019 / Revised: 5 April 2019 / Accepted: 15 April 2019 / Published: 22 April 2019
(This article belongs to the Special Issue Immunology of Fungal Infections)
Flexible adaptation to the host environment is a critical trait that underpins the success of numerous microbes. The polymorphic fungus Candida albicans has evolved to persist in the numerous challenging niches of the human body. The interaction of C. albicans with a mucosal surface is an essential prerequisite for fungal colonisation and epitomises the complex interface between microbe and host. C. albicans exhibits numerous adaptations to a healthy host that permit commensal colonisation of mucosal surfaces without provoking an overt immune response that may lead to clearance. Conversely, fungal adaptation to impaired immune fitness at mucosal surfaces enables pathogenic infiltration into underlying tissues, often with devastating consequences. This review will summarise our current understanding of the complex interactions that occur between C. albicans and the mucosal surfaces of the human body. View Full-Text
Keywords: Candida albicans; commensal; pathogen; fungus; mucosal infection; microbiota Candida albicans; commensal; pathogen; fungus; mucosal infection; microbiota
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MDPI and ACS Style

Nikou, S.-A.; Kichik, N.; Brown, R.; Ponde, N.O.; Ho, J.; Naglik, J.R.; Richardson, J.P. Candida albicans Interactions with Mucosal Surfaces during Health and Disease. Pathogens 2019, 8, 53. https://doi.org/10.3390/pathogens8020053

AMA Style

Nikou S-A, Kichik N, Brown R, Ponde NO, Ho J, Naglik JR, Richardson JP. Candida albicans Interactions with Mucosal Surfaces during Health and Disease. Pathogens. 2019; 8(2):53. https://doi.org/10.3390/pathogens8020053

Chicago/Turabian Style

Nikou, Spyridoula-Angeliki, Nessim Kichik, Rhys Brown, Nicole O. Ponde, Jemima Ho, Julian R. Naglik, and Jonathan P. Richardson 2019. "Candida albicans Interactions with Mucosal Surfaces during Health and Disease" Pathogens 8, no. 2: 53. https://doi.org/10.3390/pathogens8020053

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