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Life
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Management of Ischemia and Heart Failure—3rd Edition
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Management of Ischemia and Heart Failure—3rd Edition

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 471

Special Issue Editor

Dr. Cristian Mornoş

E-Mail Website
Guest Editor
Cardiology Department, “Victor Babes” University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania
Interests: heart failure; acute coronary syndrome; speckle tracking; tissue Doppler imaging
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are grateful to the researchers who contributed to the first and second editions of this Special Issue, linked below:

Management of Ischemia and Heart Failure: https://www.mdpi.com/journal/life/special_issues/ischemia_heart

Management of Ischemia and Heart Failure—2nd Edition: https://www.mdpi.com/journal/life/special_issues/74677OH137

We are pleased to announce the upcoming publication of the latest edition of our Special Issue, entitled “Management of Ischemia and Heart Failure—3rd Edition”.

Heart disease is the number one cause of death worldwide, within which myocardial ischemia and heart failure are some of the most important entities. Heart failure is a complex syndrome responsible for high rates of death and hospitalization. Ischemic heart disease is one of the most frequent causes of heart failure, and is normally attributed to coronary artery disease, defined by the presence of one or more obstructive plaques, which restrict coronary blood flow, causing myocardial ischemia and consequent heart failure. Coronary microvascular dysfunction results in an inability of coronary circulation to satisfy myocardial metabolic demands due to the imbalance of coronary blood flow regulatory mechanisms, including in ion channels, leading to the development of hypoxia, fibrosis and tissue death, which may determine a loss of myocardial function, even beyond the presence of atherosclerotic epicardial plaques. 

The aim of this Special Issue is to analyze and discuss major unsolved issues, from basic research to new medical and interventional options, to provide the best management strategies. Invited papers will focus on left ventricular remodeling, reperfusion injury (potential targets for treatment), prognostic markers, timing and tools to achieve optimal management in patients with ischemia and heart failure, and concepts to improve heart failure networks.

Dr. Cristian Mornoş
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • heart failure
  • myocardial ischemia
  • left ventricular remodeling
  • prognosis

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Published Papers (1 paper)

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Review

24 pages, 2060 KiB  
Review
Longitudinal Myocardial Deformation as an Emerging Biomarker for Post-Traumatic Cardiac Dysfunction
by Makhabbat Bekbossynova, Timur Saliev, Murat Mukarov, Madina Sugralimova, Arman Batpen, Anar Kozhakhmetova and Zhumagul Sholdanova
Life 2025, 15(7), 1052; https://doi.org/10.3390/life15071052 - 30 Jun 2025
Viewed by 313
Abstract
Post-traumatic cardiac dysfunction is a clinically under-recognized complication of polytrauma, often occurring in the absence of overt structural injury. Traditional diagnostic tools frequently fail to detect early or subclinical myocardial impairment, underscoring the need for more sensitive assessment methods. This review explores the [...] Read more.
Post-traumatic cardiac dysfunction is a clinically under-recognized complication of polytrauma, often occurring in the absence of overt structural injury. Traditional diagnostic tools frequently fail to detect early or subclinical myocardial impairment, underscoring the need for more sensitive assessment methods. This review explores the utility of global longitudinal strain (GLS), derived from speckle-tracking echocardiography (STE), as a sensitive biomarker for identifying and managing cardiac dysfunction following traumatic injury. It outlines the complex pathophysiology of trauma-induced myocardial impairment, including mechanical injury, systemic inflammation, oxidative stress, and neuro-hormonal activation. The limitations of conventional diagnostic approaches, such as electrocardiography, left ventricular ejection fraction (LVEF), and cardiac biomarkers, are critically assessed and contrasted with the enhanced diagnostic performance of GLS. GLS has demonstrated superior sensitivity in detecting subclinical myocardial dysfunction even when LVEF remains preserved and is associated with increased risk of long-term cardiovascular complications, including arrhythmias and heart failure. The manuscript highlights the clinical utility of GLS in early diagnosis, risk stratification, treatment monitoring, and long-term follow-up. Integration of GLS with inflammatory and oxidative biomarkers (e.g., IL-6, TNF-α, and MPO) and artificial intelligence-based diagnostic models offers potential for improved precision in trauma cardiology. Full article
(This article belongs to the Special Issue Management of Ischemia and Heart Failure—3rd Edition)
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