Special Issue "Plasticity in Cancer and in Microenvironmental Cells"
Deadline for manuscript submissions: closed (31 March 2020).
Interests: clinical cancer research; translational research; inflammatory cytokines; chemokines; extracellular matrix; head and neck oncology; cell-cell interactions; fibroblasts and mesenchymal cells; neurotrophin research; cancer stem cells; inner ear development
The plasticity of cancer tissue, which contains tumor cells, either of epithelial or mesenchymal origin, and stroma cells is a major hallmark that enables adaptation and resistance mechanisms, immune and therapy escapes, but might also contribute to successful therapy. The development of knowledge on tumor microenvironment, non-tumor cell-components effects on the support or inhibition of tumor growth, dependence and independence mechanisms of tumor cells on hormones, virus oncogenes, growth factors or driver mutations are some of the manifold dimensions of understanding of cancer tissue dynamics. This Special Issue will welcome original experimental or clinical research papers, comprehensive reviews, case reports, communications, and technical notes form any area of oncology, which attempts to contribute to the understanding of how a continuously changing interaction between tumor and stroma elements define and form the shape of cancer or allow options that enable tumor cells to escape treatment efforts. Changes in cancer cell genomes, cell population selection, conversion of bulk cancer cells to cancer stem cells, epithelial-to-mesenchymal transdifferentiation, polarization of macrophages, changes in populations of fibroblasts, myofibroblast activation, development of cancer-associated fibroblasts, functional reprogramming of microenvironmental cells, angiogenesis, and immune escape are only few examples of the numerous possibilities of how the cancer tissue adapts itself to actual conditions. Mechanical changes in the composition of the cancer microenvironment such as stiffness, the chemical constitution of cell-free environment, changes of pH, ion balance, conductivity, and equilibrium of active-, inactive-, mature-, and pro-enzymes are important and rarely discussed issues, which we would be happy to read about. We are also interested in articles about shifting between mitochondrial oxidative phosphorylation to glycolysis, hypoxia effects, unsaturated fatty acid effects. Clinical studies about related biomarkers, patient survival correlation factors and studies on tumor progression are also interesting for us. From the valuable contributions of authors to this issue, a considerate novel colorful view of the dynamic plastic nature of cancer tissue will be painted on our canvas.
Dr. Jozsef Dudas
Manuscript Submission Information
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- tumor microenvironment
- adhesion assays
- cancer models
- extracellular matrix
- tumor progression
- patient survival
- therapy outcome
- cancer stem cells
- cancer-associated fibroblasts
- cancer tissue metabolism
- genomic instability
- driver mutations
- survival factors
- mechanical barriers
- matrix degradation
- epithelial-to-mesenchymal transdifferentiation
- virus oncogenes
- tissue slice culture