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The Enigma of Centriole Loss in the 1182-4 Cell Line

Institute of Ecology and Environmental Sciences, iEES, Sorbonne University, UPEC, CNRS, IRD, INRA, F-75005 Paris, France
Laboratoire de Biologie et de Modélisation de la Cellule—CNRS UMR 5239, École Normale Supérieure de Lyon, University of Lyon, F-69007 Lyon, France
Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL 32306-4300, USA
Department of Computer Science, Florida State University, Tallahassee, FL 32306-4530, USA
Authors to whom correspondence should be addressed.
Cells 2020, 9(5), 1300;
Received: 26 April 2020 / Revised: 19 May 2020 / Accepted: 19 May 2020 / Published: 23 May 2020
(This article belongs to the Special Issue Centrosome)
The Drosophila melanogaster cell line 1182-4, which constitutively lacks centrioles, was established many years ago from haploid embryos laid by females homozygous for the maternal haploid (mh) mutation. This was the first clear example of animal cells regularly dividing in the absence of this organelle. However, the cause of the acentriolar nature of the 1182-4 cell line remained unclear and could not be clearly assigned to a particular genetic event. Here, we detail historically the longstanding mystery of the lack of centrioles in this Drosophila cell line. Recent advances, such as the characterization of the mh gene and the genomic analysis of 1182-4 cells, allow now a better understanding of the physiology of these cells. By combining these new data, we propose three reasonable hypotheses of the genesis of this remarkable phenotype. View Full-Text
Keywords: centriole; centrosome; maternal haploid; Drosophila melanogaster; cell line; haploid cells centriole; centrosome; maternal haploid; Drosophila melanogaster; cell line; haploid cells
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Debec, A.; Loppin, B.; Zheng, C.; Liu, X.; Megraw, T.L. The Enigma of Centriole Loss in the 1182-4 Cell Line. Cells 2020, 9, 1300.

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