Special Issue "Epithelial Cell Adhesion Molecule and Cancers: From Molecular Mechanisms to Therapeutic Opportunities"
Deadline for manuscript submissions: 30 April 2020.
Interests: regulation of tumor cell and embryonic stem cell differentiation; epithelial cell adhesion molecule (EpCAM); epithelial–mesenchymal transition (EMT)
Epithelial cell adhesion molecule (EpCAM) is a membrane-tethered glycoprotein, which was first discovered 40 years ago, as a humoral antigen expressed in colon cancer. Owing to its frequent and strong expression in the majority of carcinomas, EpCAM serves as a target for therapeutic monoclonal antibodies and as an anchor molecule to isolate circulating tumor cells in peripheral blood in clinical practice. At the molecular level, EpCAM was initially described as a cell adhesion protein and, more recently, as a signalling-active membrane protein involved in the regulation of proliferation, metabolism, morphogenic processes, stemness, and cell differentiation, amongst others. Beyond carcinoma cells, EpCAM is highly expressed in embryonic stem cells and various progenitor cells, in which it also displays a plethora of functions.
This Special Issue of Cells is centered around all the various aspects of EpCAM biology and aims at compiling a collection of original and review articles addressing this central topic in molecular oncology and cell differentiation. Suggested potential topics may include: EpCAM expression patterns and regulation, cellular functions, EpCAM in tumor and metastases formation, (functional) interactions with other molecules, regulation of normal and pathogenic differentiation, including EMT, and clinical and therapeutic applications.
Prof. Dr. Olivier Gires
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- normal and malignant cell differentiation
- systemic tumor cells
- metastatic cascade
- cell signaling