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On the Host Side of the Hepatitis E Virus Life Cycle

Division of Gastroenterology and Hepatology, Lausanne University Hospital and University of Lausanne, CH-1011 Lausanne, Switzerland
Author to whom correspondence should be addressed.
Cells 2020, 9(5), 1294;
Received: 28 April 2020 / Revised: 20 May 2020 / Accepted: 21 May 2020 / Published: 22 May 2020
(This article belongs to the Special Issue Cell Biology of Viral Infections)
Hepatitis E virus (HEV) infection is one of the most common causes of acute hepatitis in the world. HEV is an enterically transmitted positive-strand RNA virus found as a non-enveloped particle in bile as well as stool and as a quasi-enveloped particle in blood. Current understanding of the molecular mechanisms and host factors involved in productive HEV infection is incomplete, but recently developed model systems have facilitated rapid progress in this area. Here, we provide an overview of the HEV life cycle with a focus on the host factors required for viral entry, RNA replication, assembly and release. Further developments of HEV model systems and novel technologies should yield a broader picture in the future.
Keywords: HEV; host factor; particle production; viral replication; virus entry HEV; host factor; particle production; viral replication; virus entry
MDPI and ACS Style

Oechslin, N.; Moradpour, D.; Gouttenoire, J. On the Host Side of the Hepatitis E Virus Life Cycle. Cells 2020, 9, 1294.

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