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Special Issue "Dendritic Cells in Immunity and Inflammation"
Deadline for manuscript submissions: 31 January 2020.
Since their discovery in 1973 by the Nobel laureate Ralph Steinman and his colleague Zanvil Cohn, more than 50,000 papers have been published on dendritic cells (DCs), testifying to their absolute relevance in the landscape of immunity. DCs are truly major players in the immune system and particularly in adaptive immunity. The progress in the understanding of their biology has been impressive and in close relationship with the definition of their role in diverse human diseases. The focus of this series would be exactly on this, covering disease mechanisms that are of completely different origins, like cancer, infections or autoimmune disorders. Indeed, the attempt to modulate DC functions in opposite directions well illustrates the extraordinary therapeutic potential and the biological “flexibility” of these cells. In autoimmune disorders like lupus erythematosus or multiple sclerosis (although the term of immune-mediated disorder is probably more acceptable for multiple sclerosis), the generation of tolerogenic DC is actively pursued. Recent data also raised the intriguing possibility that DCs play a role in the evolution of degenerative diseases like amyotrophic lateral sclerosis. In cancer, by contrast, DC alerting and activation against nonself neoantigens is the strategy that has been under scrutiny in a number of clinical studies for several years. In this context, the interaction of DCs with T lymphocytes and natural killer cells is of paramount importance. Also important are the recent acquisitions in their classification, ways of purifications, as well as the innovations in their stimulation/activation for therapeutic purposes.
Finally, as the immunotherapy field is moving really fast, a new wave of interactions can be envisioned between DCs and the adoptive transfer of T cells, including chimeric antigen receptors, looking for possible synergies.
In this Special Issue of Cells, we invite contributions in the form of original research articles, reviews, or shorter perspective articles on all aspects related to dendritic cells and the themes above.
Dr. Gaetano Finocchiaro
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- dendritic cells and T cells
- dendritic cells and NK cells
- tolerogenic DC
- dendritic cells and cancer
- dendritic cells and immune-mediated diseases
- adoptive immunotherapy