Leukocytes in Inflammation, Resolution of Inflammation, Autoimmune Diseases and Cancer

Dear Colleagues,

Acute inflammation is a protective mechanism to eliminate invading pathogens. It should ideally be localized and self-limited and lead to complete resolution. Inflammation is also an important pathophysiological component of most chronic diseases, including cardiovascular, pulmonary, and immune diseases, diabetes, and cancer. Since the inflammatory response is critical for survival, the current anti-inflammatory therapies have limitations and often do not lead to repair of affected tissues. Hence, there is need for a fresh approach. While the recruitment and functions of innate immune cells have received considerable attention, accumulating data challenge many of our current concepts. Thus, identifying macrophage and neutrophil heterogeneity, characterization of novel mechanisms (for example, NETosis, swarming, reverse migration, transcriptional burst, efferocytosis), and recognition of resolution as an active process with synthesis of specialized pro-resolving mediators shed new light on the roles of leukocyte subsets in acute and chronic inflammatory conditions. Emerging topics include but are not limited to microbiota regulation of leukocyte maturation, neutrophil regulation of adaptive immunity, systemic autoimmune diseases, and cancer. This Special Issue aims to provide an overview of recent advances in these areas, with an emphasis on new avenues for therapeutic interventions.

Prof. János G. Filep
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.