Advances in Axon Degeneration and Regeneration
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Nervous System".
Deadline for manuscript submissions: closed (30 November 2020) | Viewed by 7565
Special Issue Editors
2. Department of Cell Biology, Physiology and Immunology, Universitat de Barcelona, 08028 Barcelona, Spain
3. Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED), Barcelona, Spain
4. Institute of Neuroscience, University of Barcelona, 08007 Barcelona, Spain
Interests: in vitro models of neurodegeneration and regeneration; lab-on-chip technologies; inhibitory molecules after lesion; olphactory enshething cells
Interests: axonal injuries; neuroinflamation; intrinsic mechanisms of neural regeneration; neurorehabilitation; metabolism in axonal injuries
Special Issue Information
Dear Colleagues,
Traumatic neuronal injuries, including peripheral nerve injuries (PNI), traumatic brain injury (TBI), or spinal cord injury (SCI), cause long-term functional deficits that represent a big hurdle in the quality of life of patients who suffer them. Loss of function is caused by the disconnection of axons. Injured axons undergo a degenerative process and are unable to reattach to restore function. Consequently, axon degeneration and the lack of functional axonal regeneration are the pivotal pathological events of acute traumatic neuronal injuries. Axon degeneration is an active cellular program and yet molecularly distinct from cell death. In recent years, much effort has been devoted toward understanding the nature of axon degeneration and promoting axon regeneration; however, the fundamental mechanisms of self-destruction of damaged axons and the intrinsic inability to regenerate still remain unclear, causing a worrying lack of effective treatments for chronic axonal injuries. In this Special Issue, we aim to include breakthrough findings, ranking from new strategies (in vitro or in vivo) to clinical approaches to understand fundamental and challenging issues behind axonal regeneration failure. We will focus on how these mechanistic insights hold promises for accelerating and identifying potential therapeutic targets for chronic axonal injuries. Both original research articles and reviews are welcome.
Dr. José Antonio Del Río
Dr. Arnau Hervera
Guest Editors
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Keywords
- Advances in mechanisms of axonal degeneration: Cellular signalling, paracrine communication.
- Advances in axonal regeneration: Neurorehabilitation, Neuroinflammation, Intrisic mechanisms, Metabolic regulation.
- Novel in vitro and in vivo models of axonal degeneration and regeneration
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