Table of Contents
Cells, Volume 8, Issue 8 (August 2019)
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Cover Story (view full-size image) The figure shows promyelocytic leukemia (PML) bodies at different stages of the cell cycle. In [...] Read more. The figure shows promyelocytic leukemia (PML) bodies at different stages of the cell cycle. In interphase cells, nuclear PML forms spherical nuclear structures which recruit and release various nuclear proteins. In mitosis, these structures aggregate to form multispherical complexes. The mitotic PML bodies end up in the cytoplasm of newly divided G1 cells, where they immediately become covered with nuclear import factors. In this volume of Cells, Lång et al. review biochemical and biophysical transitions of PML bodies during cell cycle progression, and they discuss this behavior in light of putative PML body cellular functions. The confocal images in the cover illustration show fixed HaCaT cells with immunofluorescently labeled PML (red), importin β (green), and DAPI (blue). View this paper