Membrane Traffic in Health and Disease
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (15 November 2019) | Viewed by 92763
Special Issue Editor
Special Issue Information
Dear Colleagues,
The secretory pathway is the place for the synthesis, quality control, and sorting of roughly a third of the eukaryotic proteome. Given that 70% of the cellular energy is devoted to protein synthesis, it is evident that the secretory pathway is essential for cellular and organismal development homeostasis. Besides, handling a large fraction of the proteins, the secretory pathway is also involved in lipid homeostasis. Because of its prominent role in handling lipids and proteins, it is not surprising to find that alterations in the fucntion of the secretory pathway are found in or underlie a wide variety of diseases such as metabolic disorders, neurodegenerative diseases, and cancer.
This Special Issue of Cells aims to improve our understanding of the role of the secretory pathway in health and diseases and will cover topics such as:
- Alterations of organelle homeostasis in cancer, metabolic diseases, and neurodegeneration
- Spatial organization of signaling of kinases, phosphatases, and small GTPases
- The role of autophagic trafficking in diseases
- The response of the secretory pathway to stress
- The role of glycosylation in cancer
- Mathematical models of the secretory pathway as tools to understand diseases
Dr. Hesso Farhan
Guest Editor
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Keywords
- Endoplasmic reticulum
- Golgi apparatus
- Autophagy
- Cell migration
- COPII vesicles
- Glycosylation
- Organelles
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