Special Issue "Regulatory T (Treg) Cells in Health and Diseases"
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (15 July 2019).
Regulatory T cells (Tregs) are immunosuppressive cells that are essential for maintaining homeostasis and immune tolerance. These cells are best identified by their expression of a unique transcription factor forkhead box transcription factor (Foxp3) that controls their characteristic regulatory function. Tregs play important, well-characterized roles in the development and outcomes of diverse pathologies ranging from inflammatory diseases and autoimmunity to graft rejection and cancer. Defects in Treg function can lead to the development of numerous autoimmune disorders including autoimmune thyroid disease (AITD), immunodysregulation polyendocrinopathy enteropathy X-linked syndrome (IPEX), and multiple sclerosis. In contrast, Tregs accumulate in cancer patients and especially within the tumor microenvironment, where they suppress anti-tumor immunity. A better understanding of Tregs across various disease and physiological settings will be critical for the targeting of these cells for therapeutic benefits. The aim of this Special Issue is to provide a platform for investigators to share their insights and critically discuss breakthroughs relevant to the cellular and molecular factors that affect CD4+Foxp3+ Treg development, homeostasis, and function; the role and function of Tregs in health and different diseases; and the current status of therapeutic approaches with the potential to modulate Tregs and alter outcomes of experimental animal and human disease.
Dr. Fan Pan
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- regulatory T cells
- autoimmune disease