Table of Contents
Cells, Volume 8, Issue 7 (July 2019) – 128 articles
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Cover Story (view full-size image) The sympathetic and parasympathetic nervous systems are essential modulators of the intestinal [...] Read more. The sympathetic and parasympathetic nervous systems are essential modulators of the intestinal immune system, with the enteric nervous system acting as a potential interface. It remains, however, to be elucidated which specific nerves, neurotransmitters, neuropeptides, and receptors are accountable and which immune cells are involved. Adrenergic and cholinergic neuronal activity can further modulate the homeostasis of specialized epithelial cells in the crypt stem cell niche and hence also impact the mucosal barrier and the intestinal microbiota. The autonomic nervous system is therefore a potential therapeutic target for intestinal inflammatory diseases, and the advancement of new neuromodulatory techniques such as bioelectronic implantable devices must be pursued. View this paper.