CSCs Identification and Targeting Therapies: Advances and Challenges
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Stem Cells".
Deadline for manuscript submissions: closed (15 July 2019) | Viewed by 25720
Special Issue Editors
Interests: cancer stem cells (CSCs); CSCs’ specific biomarkers; CSCs’ targeting therapies; epithelial–mesenchymal transition; cancer invasion and metastasis
Interests: stem cells; cancer stem cells; cancer stem cells identification and eradication; bone; remodeling; sarcomas; adipose stem cells; differentiation; head and neck cancer
Special Issue Information
Dear Colleagues,
Chemoresistance is a major problem in cancer therapy, as aggressive cancer cells develop mechanisms to counteract chemotherapeutic drugs. Cancer stem cells (CSCs) are considered to be at the origin of cancer relapse and recurrence in cancer patients and following chemotherapy. Like their stem cell counterparts, CSCs possess the stemness properties of self-renewal and the ability to generate differentiated cells that contribute to tumor heterogeneity. Although several CSC biomarkers have been identified, the specificity of their expression remains a concern. Therefore, the identification of specific CSC biomarkers and associated cellular pathways for targeted cancer therapies is a major challenge facing scientists and clinicians working in this moving field. This issue will focus on refining recent advances in our understanding of CSCs’ role in chemoresistance and cancer progression, and determine available therapeutic strategies to target these highly malignant cells.
Dr. Tarik Regad
Prof. Gianpaolo Papaccio
Guest Editors
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Keywords
- Cancer stem cells
- Invasion
- Metastasis
- Chemoresistance
- Epithelial–mesenchymal transition
- Biomarkers
- CSC-targeting therapies
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